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Associations Betwee...
Abstract
Ämnesord
Stäng
- Individuals with diabetes mellitus are advised to achieve a healthy weight to prevent complications. However, fat mass distribution has hardly been investigated as a risk factor for diabetes complications. The authors studied associations between body mass index, waist circumference, waist/hip ratio, and waist/height ratio and mortality among individuals with diabetes mellitus. Within the European Prospective Investigation into Cancer and Nutrition, a subcohort was defined as 5,435 individuals with a confirmed self-report of diabetes mellitus at baseline in 1992-2000. Participants were aged 57.3 (standard deviation, 6.3) years, 54% were men, the median diabetes duration was 4.6 (interquartile range, 2.0-9.8) years, and 22% of the participants used insulin. Body mass index, as indicator of general obesity, was not associated with higher mortality, whereas all measurements of abdominal obesity showed a positive association. Associations generally were slightly weaker in women. The strongest association was observed for waist/height ratio: In the fifth quintile, the hazard rate ratio was 1.88 (95% confidence interval: 1.33, 2.65) for men and 2.46 (95% confidence interval: 1.46, 4.14) for women. Measurements of abdominal, but not general, adiposity were associated with higher mortality in diabetic individuals. The waist/height ratio showed the strongest association. Respective indicators might be investigated in risk prediction models.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- adiposity
- body mass index
- diabetes complications
- diabetes mellitus
- mortality
- waist circumference
- waist-hip ratio
- adiposity
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Sluik, Diewertje
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Boeing, Heiner
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Montonen, Jukka
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Pischon, Tobias
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Kaaks, Rudolf
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Teucher, Birgit
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Tjonneland, Anne
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Halkjaer, Jytte
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Berentzen, Tina ...
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Overvad, Kim
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Arriola, Larrait ...
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Ardanaz, Eva
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Bendinelli, Bene ...
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Grioni, Sara
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Tumino, Rosario
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Sacerdote, Carlo ...
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Mattiello, Amali ...
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Spijkerman, Anne ...
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van der A, Daphn ...
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Beulens, Joline ...
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van der Schouw, ...
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Nilsson, Peter
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Hedblad, Bo
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Rolandsson, Olov
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Franks, Paul
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Noethlings, Ute
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