Sökning: onr:"swepub:oai:lup.lub.lu.se:e8d7ef7a-50b4-48da-b45c-c6cd5783e71f" > Cause of death base...
Fältnamn | Indikatorer | Metadata |
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000 | 04135naa a2200433 4500 | |
001 | oai:lup.lub.lu.se:e8d7ef7a-50b4-48da-b45c-c6cd5783e71f | |
003 | SwePub | |
008 | 220412s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/e8d7ef7a-50b4-48da-b45c-c6cd5783e71f2 URI |
024 | 7 | a https://doi.org/10.1111/joim.133002 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Romanova, E. S.u North-Western State Medical University named after I.I. Mechnikov4 aut |
245 | 1 0 | a Cause of death based on systematic post-mortem studies in patients with positive SARS-CoV-2 tissue PCR during the COVID-19 pandemic |
264 | c 2021-05-20 | |
264 | 1 | b Wiley,c 2021 |
300 | a 11 s. | |
520 | a Importance: Assessment of the causative association between the COVID-19 and cause of death has been hampered by limited availability of systematically performed autopsies. We aimed to present autopsy-confirmed causes of death in patients who died with COVID-19 and to assess the association between thrombosis and diffuse alveolar damage consistent with COVID-19 (DAD). Methods: Consecutive forensic (n = 60) and clinical (n = 42) autopsies with positive post-mortem SARS-CoV-2 PCR in lungs (age 73 ± 14 years, 50% men) were included. The cause of death analysis was based on a review of medical records and histological reports. Thrombotic phenomena in lungs were defined as pulmonary thromboembolism (PE), thrombosis in pulmonary artery branches or microangiopathy in capillary vessels. Results: COVID-19 caused or contributed to death in 71% of clinical and 83% of forensic autopsies, in whom significant DAD was observed. Of the patients with COVID-19 as the primary cause of death, only 19% had no thrombotic phenomena in the lungs, as opposed to 38% amongst those with COVID-19 as a contributing cause of death and 54% amongst patients whose death was not related to COVID-19 (p = 0.002). PE was observed in 5 patients. Two patients fulfilled the criteria for lymphocyte myocarditis. Conclusions: Vast majority of all PCR-positive fatalities, including out-of-hospital deaths, during the SARS-CoV-2 pandemic were related to DAD caused by COVID-19. Pulmonary artery thrombosis and microangiopathy in pulmonary tissue were common and associated with the presence of DAD, whilst venous PE was rarely observed. Histology-confirmed lymphocyte myocarditis was a rare finding. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a COVID-19 | |
653 | a forensic autopsy | |
653 | a pathology | |
700 | 1 | a Vasilyev, V. V.u North-Western State Medical University named after I.I. Mechnikov4 aut |
700 | 1 | a Startseva, G.u North-Western State Medical University named after I.I. Mechnikov4 aut |
700 | 1 | a Karev, V.u Pediatric Research and Clinical Center for Infectious Diseases, St. Petersburg4 aut |
700 | 1 | a Rybakova, M. G.u Pavlov University4 aut |
700 | 1 | a Platonov, P. G.u Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)kard-ppl |
710 | 2 | a North-Western State Medical University named after I.I. Mechnikovb Pediatric Research and Clinical Center for Infectious Diseases, St. Petersburg4 org |
773 | 0 | t Journal of Internal Medicined : Wileyg 290:3, s. 655-665q 290:3<655-665x 0954-6820x 1365-2796 |
856 | 4 | u http://dx.doi.org/10.1111/joim.13300x freey FULLTEXT |
856 | 4 | u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250818 |
856 | 4 8 | u https://lup.lub.lu.se/record/e8d7ef7a-50b4-48da-b45c-c6cd5783e71f |
856 | 4 8 | u https://doi.org/10.1111/joim.13300 |
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