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Dynamic 2D and 3D m...
Dynamic 2D and 3D mapping of hyperpolarized pyruvate to lactate conversion in vivo with efficient multi-echo balanced steady-state free precession at 3 T
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- Müller, Christoph A. (författare)
- Albert-Ludwigs University Freiburg,German Cancer Research Centre
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- Hundshammer, Christian (författare)
- Klinikum rechts der Isar
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- Braeuer, Miriam (författare)
- Klinikum rechts der Isar
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- Skinner, Jason G. (författare)
- Klinikum rechts der Isar,Albert-Ludwigs University Freiburg
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- Berner, Stephan (författare)
- Albert-Ludwigs University Freiburg,German Cancer Research Centre
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- Leupold, Jochen (författare)
- Albert-Ludwigs University Freiburg
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- Düwel, Stephan (författare)
- Klinikum rechts der Isar
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- Nekolla, Stephan G. (författare)
- Klinikum rechts der Isar
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- Månsson, Sven (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups,Skåne University Hospital
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- Hansen, Adam E. (författare)
- University of Copenhagen
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- von Elverfeldt, Dominik (författare)
- Albert-Ludwigs University Freiburg
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- Ardenkjaer-Larsen, Jan H. (författare)
- Technical University of Denmark
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- Schilling, Franz (författare)
- Klinikum rechts der Isar
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- Schwaiger, Markus (författare)
- Klinikum rechts der Isar
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- Hennig, Jürgen (författare)
- Albert-Ludwigs University Freiburg
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- Hövener, Jan Bernd (författare)
- University Medical Center Schleswig-Holstein,Albert-Ludwigs University Freiburg
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(creator_code:org_t)
- 2020-03-10
- 2020
- Engelska.
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Ingår i: NMR in Biomedicine. - : Wiley. - 0952-3480 .- 1099-1492. ; 33:6
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this study was to acquire the transient MRI signal of hyperpolarized tracers and their metabolites efficiently, for which specialized imaging sequences are required. In this work, a multi-echo balanced steady-state free precession (me-bSSFP) sequence with Iterative Decomposition with Echo Asymmetry and Least squares estimation (IDEAL) reconstruction was implemented on a clinical 3 T positron-emission tomography/MRI system for fast 2D and 3D metabolic imaging. Simulations were conducted to obtain signal-efficient sequence protocols for the metabolic imaging of hyperpolarized biomolecules. The sequence was applied in vitro and in vivo for probing the enzymatic exchange of hyperpolarized [1–13C]pyruvate and [1–13C]lactate. Chemical shift resolution was achieved using a least-square, iterative chemical species separation algorithm in the reconstruction. In vitro, metabolic conversion rate measurements from me-bSSFP were compared with NMR spectroscopy and free induction decay-chemical shift imaging (FID-CSI). In vivo, a rat MAT-B-III tumor model was imaged with me-bSSFP and FID-CSI. 2D metabolite maps of [1–13C]pyruvate and [1–13C]lactate acquired with me-bSSFP showed the same spatial distributions as FID-CSI. The pyruvate-lactate conversion kinetics measured with me-bSSFP and NMR corresponded well. Dynamic 2D metabolite mapping with me-bSSFP enabled the acquisition of up to 420 time frames (scan time: 180-350 ms/frame) before the hyperpolarized [1–13C]pyruvate was relaxed below noise level. 3D metabolite mapping with a large field of view (180 × 180 × 48 mm3) and high spatial resolution (5.6 × 5.6 × 2 mm3) was conducted with me-bSSFP in a scan time of 8.2 seconds. It was concluded that Me-bSSFP improves the spatial and temporal resolution for metabolic imaging of hyperpolarized [1–13C]pyruvate and [1–13C]lactate compared with either of the FID-CSI or EPSI methods reported at 3 T, providing new possibilities for clinical and preclinical applications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik -- Signalbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering -- Signal Processing (hsv//eng)
Nyckelord
- balanced steady-state free precession
- carbon-13
- dynamic nuclear polarization
- hyperpolarization
- magnetic resonance imaging
- metabolite mapping
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Müller, Christop ...
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Hundshammer, Chr ...
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Braeuer, Miriam
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Skinner, Jason G ...
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Berner, Stephan
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Leupold, Jochen
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visa fler...
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Düwel, Stephan
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Nekolla, Stephan ...
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Månsson, Sven
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Hansen, Adam E.
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von Elverfeldt, ...
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Ardenkjaer-Larse ...
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Schilling, Franz
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Schwaiger, Marku ...
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Hennig, Jürgen
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Hövener, Jan Ber ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Elektroteknik oc ...
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och Signalbehandling
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NMR in Biomedici ...
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Lunds universitet