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Increase of bikunin...
Increase of bikunin and alpha1-microglobulin concentrations in urine of rats during pregnancy is due to decreased tubular reabsorption
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- Blom, Anna M (författare)
- Uppsala University
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- Falkenberg, Cecilia (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Sjöquist, Mats (författare)
- Uppsala University
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- Eriksson, Ulf J (författare)
- Uppsala University
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- Åkerström, Bo (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Antioxidationsmedicin,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Antioxidation medicine,Lund University Research Groups
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- Fries, Erika (författare)
- Uppsala University
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(creator_code:org_t)
- 1997
- 1997
- Engelska 5 s.
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Ingår i: Biochimica et Biophysica Acta. - 0006-3002. ; 1361:2, s. 198-202
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Bikunin and alpha1-microglobulin are two plasma proteins of about 25 kDa which are made in the liver from a common precursor. The concentration of bikunin in human urine has been shown to increase several fold during various conditions of stress. The mechanism behind this increase is unknown. We have studied pregnant rats and found that the bikunin and alpha1-microglobulin levels in their urine increased 3-fold towards the end of the pregnancy, whereas those of albumin and orosomucoid did not. There were no significant changes in either the bikunin/alpha1-microglobulin mRNA level or the concentrations of the two proteins in serum. These findings imply that the synthesis and the clearance rates of bikunin and alpha1-microglobulin are normal during pregnancy but that the tubular reabsorption of these proteins is decreased.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Alpha-Globulins/analysis
- Animals
- Female
- Glycoproteins/blood
- Kidney Tubules/metabolism
- Liver/metabolism
- Membrane Glycoproteins
- Orosomucoid/analysis
- Pregnancy/blood
- RNA, Messenger/isolation & purification
- Rats
- Rats, Sprague-Dawley
- Trypsin Inhibitor, Kunitz Soybean
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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