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A protective geneti...
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Carli, VKarolinska Institutet
(författare)
A protective genetic variant for adverse environments? The role of childhood traumas and serotonin transporter gene on resilience and depressive severity in a high-risk population
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2020-04-16
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Cambridge University Press (CUP),2011
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:123617447
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123617447URI
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https://doi.org/10.1016/j.eurpsy.2011.04.008DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Genetic aspects may influence the effect of early adverse events on psychological well being in adulthood. In particular, a common polymorphism within the serotonin transporter gene (5-HTTLPR short/long) has been associated to the risk for stress-induced psychopathology. In the present study we investigated the role of childhood traumas and 5-HTTLPR on measures of psychological resilience and depression in a sample of individuals at a high risk for psychological distress (763 male prisoners). The 5-HTTLPR genotype did not influence resilience and depressive severity. However, a significant interaction was observed between 5-HTTLPR and childhood traumas on both resilience and depressive severity. In particular, among subjects exposed to severe childhood trauma only, the long-allele was associated to lower resilience scores and increased current depressive severity as compared to short/short homozygous. Sex specific effects, difference in type and duration of stressors and the specific composition of the sample may explain discrepancy with many studies reporting the short-allele as a vulnerability factor for reactivity to stress. We here speculated that in males the long-allele may confer lower resilience and therefore higher vulnerability for depressive symptoms in subjects exposed to early stress and currently living in stressful environments.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mandelli, L
(författare)
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Zaninotto, L
(författare)
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Roy, A
(författare)
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Recchia, L
(författare)
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Stoppia, L
(författare)
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Gatta, V
(författare)
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Sarchiapone, M
(författare)
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Serretti, A
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European psychiatry : the journal of the Association of European Psychiatrists: Cambridge University Press (CUP)26:8, s. 471-4781778-3585
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Ingår i:European Psychiatry: Cambridge University Press (CUP)26:8, s. 471-4780924-9338
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