Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:145245162" > Nrf2-interacting nu...
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000 | 25520naa a2208689 4500 | |
001 | oai:prod.swepub.kib.ki.se:145245162 | |
003 | SwePub | |
008 | 240825s2020 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1452451622 URI |
024 | 7 | a https://doi.org/10.1186/s13601-020-00362-72 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bousquet, J4 aut |
245 | 1 0 | a Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies |
264 | c 2020-12-03 | |
264 | 1 | b Wiley,c 2020 |
520 | a There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity. | |
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700 | 1 | a Puggioni, F4 aut |
700 | 1 | a Puig-Domenech, E4 aut |
700 | 1 | a Puy, R4 aut |
700 | 1 | a Rabe, K4 aut |
700 | 1 | a Rabotti, S4 aut |
700 | 1 | a Raciborski, F4 aut |
700 | 1 | a Ramos, J4 aut |
700 | 1 | a Recalcati, C4 aut |
700 | 1 | a Recto, MT4 aut |
700 | 1 | a Reda, SM4 aut |
700 | 1 | a Regateiro, FS4 aut |
700 | 1 | a Reider, N4 aut |
700 | 1 | a Reitsma, S4 aut |
700 | 1 | a Repka-Ramirez, S4 aut |
700 | 1 | a Ridolo, E4 aut |
700 | 1 | a Rimmer, J4 aut |
700 | 1 | a Yeverino, DR4 aut |
700 | 1 | a Rizzo, JA4 aut |
700 | 1 | a Robalo-Cordeiro, C4 aut |
700 | 1 | a Roberts, G4 aut |
700 | 1 | a Robles, K4 aut |
700 | 1 | a Roche, N4 aut |
700 | 1 | a Gonzalez, MR4 aut |
700 | 1 | a Zagal, ER4 aut |
700 | 1 | a Rolla, G4 aut |
700 | 1 | a Rolland, C4 aut |
700 | 1 | a Roller-Wirnsberger, R4 aut |
700 | 1 | a Rodriguez, MR4 aut |
700 | 1 | a Romano, A4 aut |
700 | 1 | a Romantowski, J4 aut |
700 | 1 | a Rombaux, P4 aut |
700 | 1 | a Romualdez, J4 aut |
700 | 1 | a Rosado-Pinto, J4 aut |
700 | 1 | a Rosario, N4 aut |
700 | 1 | a Rosenwasser, L4 aut |
700 | 1 | a Rossi, O4 aut |
700 | 1 | a Rottem, M4 aut |
700 | 1 | a Rouadi, PW4 aut |
700 | 1 | a Rovina, N4 aut |
700 | 1 | a Sinur, IR4 aut |
700 | 1 | a Ruiz, M4 aut |
700 | 1 | a Segura, LTR4 aut |
700 | 1 | a Ryan, D4 aut |
700 | 1 | a Sagara, H4 aut |
700 | 1 | a Sakai, D4 aut |
700 | 1 | a Sakurai, D4 aut |
700 | 1 | a Saleh, W4 aut |
700 | 1 | a Salimaki, J4 aut |
700 | 1 | a Samitas, K4 aut |
700 | 1 | a Samolinski, B4 aut |
700 | 1 | a Coronel, MGS4 aut |
700 | 1 | a Sanchez-Borges, M4 aut |
700 | 1 | a Sanchez-Lopez, J4 aut |
700 | 1 | a Sansonna, M4 aut |
700 | 1 | a Sarafoleanu, C4 aut |
700 | 1 | a Serpa, FS4 aut |
700 | 1 | a Sastre, J4 aut |
700 | 1 | a Savi, E4 aut |
700 | 1 | a Savonyte, A4 aut |
700 | 1 | a Sawaf, B4 aut |
700 | 1 | a Scadding, GK4 aut |
700 | 1 | a Scheire, S4 aut |
700 | 1 | a Schmid-Grendelmeier, P4 aut |
700 | 1 | a Schuhl, JF4 aut |
700 | 1 | a Schunemann, H4 aut |
700 | 1 | a Schvalbova, M4 aut |
700 | 1 | a Schwarze, J4 aut |
700 | 1 | a Scichilone, N4 aut |
700 | 1 | a Senna, G4 aut |
700 | 1 | a Sepulveda, C4 aut |
700 | 1 | a Serrano, E4 aut |
700 | 1 | a Shamai, S4 aut |
700 | 1 | a Sheikh, A4 aut |
700 | 1 | a Shields, M4 aut |
700 | 1 | a Shishkov, V4 aut |
700 | 1 | a Siafakas, N4 aut |
700 | 1 | a Simeonov, A4 aut |
700 | 1 | a Simons, EF4 aut |
700 | 1 | a Sisul, JC4 aut |
700 | 1 | a Sitkauskiene, B4 aut |
700 | 1 | a Skrindo, I4 aut |
700 | 1 | a Kosak, TS4 aut |
700 | 1 | a Sole, D4 aut |
700 | 1 | a Sondermann, M4 aut |
700 | 1 | a Sooronbaev, T4 aut |
700 | 1 | a Soto-Martinez, M4 aut |
700 | 1 | a Soto-Quiros, M4 aut |
700 | 1 | a Pinto, BS4 aut |
700 | 1 | a Sova, M4 aut |
700 | 1 | a Soyka, M4 aut |
700 | 1 | a Specjalski, K4 aut |
700 | 1 | a Sperl, A4 aut |
700 | 1 | a Spranger, O4 aut |
700 | 1 | a Stamataki, S4 aut |
700 | 1 | a Stefanaki, L4 aut |
700 | 1 | a Stellato, C4 aut |
700 | 1 | a Stelmach, R4 aut |
700 | 1 | a Strandberg, T4 aut |
700 | 1 | a Stute, P4 aut |
700 | 1 | a Subramaniam, A4 aut |
700 | 1 | a Ulrik, CS4 aut |
700 | 1 | a Sutherland, M4 aut |
700 | 1 | a Sylvestre, S4 aut |
700 | 1 | a Syrigou, A4 aut |
700 | 1 | a Barata, LT4 aut |
700 | 1 | a Takovska, N4 aut |
700 | 1 | a Tan, RC4 aut |
700 | 1 | a Tan, FC4 aut |
700 | 1 | a Tan, VC4 aut |
700 | 1 | a Tang, IP4 aut |
700 | 1 | a Taniguchi, M4 aut |
700 | 1 | a Tannert, L4 aut |
700 | 1 | a Tantilipikorn, P4 aut |
700 | 1 | a Tattersall, J4 aut |
700 | 1 | a Tesi, F4 aut |
700 | 1 | a Thieme, U4 aut |
700 | 1 | a Thijs, C4 aut |
700 | 1 | a Thomas, M4 aut |
700 | 1 | a To, T4 aut |
700 | 1 | a Todo-Bom, AM4 aut |
700 | 1 | a Togias, A4 aut |
700 | 1 | a Tomazic, PV4 aut |
700 | 1 | a Tomic-Spiric, V4 aut |
700 | 1 | a Toppila-Salmi, S4 aut |
700 | 1 | a Jaen, MJT4 aut |
700 | 1 | a Toskala, E4 aut |
700 | 1 | a Triggiani, M4 aut |
700 | 1 | a Triller, N4 aut |
700 | 1 | a Triller, K4 aut |
700 | 1 | a Tsiligianni, I4 aut |
700 | 1 | a Uberti, M4 aut |
700 | 1 | a Ulmeanu, R4 aut |
700 | 1 | a Urbancic, J4 aut |
700 | 1 | a Pereira, MU4 aut |
700 | 1 | a Vachova, M4 aut |
700 | 1 | a Valdes, F4 aut |
700 | 1 | a Valenta, R4 aut |
700 | 1 | a Rostan, MV4 aut |
700 | 1 | a Valero, A4 aut |
700 | 1 | a Valiulis, A4 aut |
700 | 1 | a Vallianatou, M4 aut |
700 | 1 | a Valovirta, E4 aut |
700 | 1 | a Van Eerd, M4 aut |
700 | 1 | a Van Ganse, E4 aut |
700 | 1 | a van Hage, M4 aut |
700 | 1 | a Vandenplas, O4 aut |
700 | 1 | a Vasankari, T4 aut |
700 | 1 | a Vassileva, D4 aut |
700 | 1 | a Munoz, CV4 aut |
700 | 1 | a Ventura, MT4 aut |
700 | 1 | a Vera-Munoz, C4 aut |
700 | 1 | a Viart, F4 aut |
700 | 1 | a Vicheva, D4 aut |
700 | 1 | a Vichyanond, P4 aut |
700 | 1 | a Vidgren, P4 aut |
700 | 1 | a Viegi, G4 aut |
700 | 1 | a Vogelmeier, C4 aut |
700 | 1 | a Von Hertzen, L4 aut |
700 | 1 | a Vontetsianos, T4 aut |
700 | 1 | a Vourdas, D4 aut |
700 | 1 | a Quan, VTT4 aut |
700 | 1 | a Wagenmann, M4 aut |
700 | 1 | a Walker, S4 aut |
700 | 1 | a Wallace, D4 aut |
700 | 1 | a De Wang, Y4 aut |
700 | 1 | a Waserman, S4 aut |
700 | 1 | a Wehner, K4 aut |
700 | 1 | a Wickman, M4 aut |
700 | 1 | a Williams, S4 aut |
700 | 1 | a Williams, D4 aut |
700 | 1 | a Wilson, N4 aut |
700 | 1 | a Wong, G4 aut |
700 | 1 | a Woo, K4 aut |
700 | 1 | a Wozniak, L4 aut |
700 | 1 | a Wright, J4 aut |
700 | 1 | a Wroczynski, P4 aut |
700 | 1 | a Xepapadaki, P4 aut |
700 | 1 | a Yakovliev, P4 aut |
700 | 1 | a Yamaguchi, M4 aut |
700 | 1 | a Yan, K4 aut |
700 | 1 | a Yap, YY4 aut |
700 | 1 | a Yassin, M4 aut |
700 | 1 | a Yawn, B4 aut |
700 | 1 | a Yiallouros, P4 aut |
700 | 1 | a Yorgancioglu, A4 aut |
700 | 1 | a Yoshihara, S4 aut |
700 | 1 | a Young, I4 aut |
700 | 1 | a Yusuf, OB4 aut |
700 | 1 | a Zaidi, A4 aut |
700 | 1 | a Zaitoun, F4 aut |
700 | 1 | a Zalud, P4 aut |
700 | 1 | a Zar, H4 aut |
700 | 1 | a Zedda, MT4 aut |
700 | 1 | a Zernotti, ME4 aut |
700 | 1 | a Zhang, L4 aut |
700 | 1 | a Zhong, NN4 aut |
700 | 1 | a Zidarn, M4 aut |
700 | 1 | a Zuberbier, T4 aut |
700 | 1 | a Zubrinich, C4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Clinical and translational allergyd : Wileyg 10:1, s. 58-q 10:1<58-x 2045-7022 |
856 | 4 | u https://ctajournal.biomedcentral.com/track/pdf/10.1186/s13601-020-00362-7 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145245162 |
856 | 4 8 | u https://doi.org/10.1186/s13601-020-00362-7 |
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