Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:147455126" >
PER Gene Family Pol...
PER Gene Family Polymorphisms in Relation to Cluster Headache and Circadian Rhythm in Sweden
-
- Olofsgard, FJ (författare)
- Karolinska Institutet
-
- Ran, C (författare)
- Karolinska Institutet
-
- Fourier, C (författare)
- Karolinska Institutet
-
visa fler...
-
Wirth, C (författare)
-
- Sjostrand, C (författare)
- Karolinska Institutet
-
- Waldenlind, E (författare)
- Karolinska Institutet
-
- Steinberg, A (författare)
- Karolinska Institutet
-
- Belin, AC (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2021-08-23
- 2021
- Engelska.
-
Ingår i: Brain sciences. - : MDPI AG. - 2076-3425. ; 11:8
- Relaterad länk:
-
https://www.mdpi.com...
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- The trigeminal autonomic cephalalgia, cluster headache (CH), is one of the most painful disorders known to man. One of the disorder’s most striking features is the reported diurnal rhythmicity of the attacks. For a majority of patients, the headache attacks occur at approximately the same time every day. Genetic variants of genes involved in the circadian rhythm such as Period Circadian Regulator 1, 2, and 3 (PER1, 2 and 3) are hypothesized to have an effect on the rhythmicity of the attacks. Six PER1, 2 and 3 genetic markers; the indel rs57875989 and five single nucleotide polymorphisms (SNPs), rs2735611, rs2304672, rs934945, rs10462020, and rs228697, were genotyped, using TaqMan® or regular polymerase chain reaction (PCR), in a Swedish CH case control material. Logistic regression showed no association between CH and any of the six genetic variants; rs57875989, p = 0.523; rs2735611, p = 0.416; rs2304672, p = 0.732; rs934945, p = 0.907; rs10462020, p = 0.726; and rs228697, p = 0.717. Furthermore, no difference in allele frequency was found for patients reporting diurnal rhythmicity of attacks, nor were any of the variants linked to diurnal preference. The results of this study indicate no involvement of these PER genetic variants in CH or diurnal phenotype in Sweden.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas