Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:147558934" >
Zanubrutinib monoth...
Zanubrutinib monotherapy for patients with treatment naïve chronic lymphocytic leukemia and 17p deletion
-
Tam, CS (författare)
-
Robak, T (författare)
-
Ghia, P (författare)
-
visa fler...
-
Kahl, BS (författare)
-
Walker, P (författare)
-
Janowski, W (författare)
-
Simpson, D (författare)
-
Shadman, M (författare)
-
Ganly, PS (författare)
-
Laurenti, L (författare)
-
Opat, S (författare)
-
Tani, M (författare)
-
Ciepluch, H (författare)
-
Verner, E (författare)
-
Simkovi, M (författare)
-
- Osterborg, A (författare)
- Karolinska Institutet
-
Trneny, M (författare)
-
Tedeschi, A (författare)
-
Paik, JC (författare)
-
Kuwahara, SB (författare)
-
Feng, SB (författare)
-
Ramakrishnan, V (författare)
-
Cohen, A (författare)
-
Huang, J (författare)
-
Hillmen, P (författare)
-
Brown, JR (författare)
-
visa färre...
-
(creator_code:org_t)
- 2020-10-13
- 2021
- Engelska.
-
Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 106:9, s. 2354-2363
- Relaterad länk:
-
https://haematologic...
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Patients with chronic lymphocytic leukemia or small lymphocytic lymphoma whose tumors carry deletion of chromosome 17p13.1 [del(17p)] have an unfavorable prognosis and respond poorly to standard chemoimmunotherapy. Zanubrutinib is a selective next-generation Bruton tyrosine kinase inhibitor. We evaluated the safety and efficacy of zanubrutinib 160 mg twice daily in treatment-naïve patients with del(17p) disease enrolled in a dedicated, nonrandomized cohort (Arm C) of the phase 3 SEQUOIA trial. A total of 109 patients (median age, 70 years; range, 42 – 86) with centrally confirmed del(17p) were enrolled and treated. After a median of 18.2 months (range, 5.0 – 26.3), seven patients had discontinued study treatment due to progressive disease, four due to an adverse event, and one due to withdrawal of consent. The overall response rate was 94.5% with 3.7% of patients achieving complete response with or without incomplete hematologic recovery. The estimated 18-month progression-free survival rate was 88.6% (95% CI, 79.0 – 94.0) and the estimated 18-month overall survival rate was 95.1% (95% CI, 88.4 – 98.0). Most common all-grade adverse events included contusion (20.2%), upper respiratory tract infection (19.3%), neutropenia/neutrophil count decreased (17.4%), and diarrhea (16.5%). Grade ≥ 3 adverse events were reported in 53 patients (48.6%), most commonly neutropenia (12.9%) and pneumonia (3.7%). An adverse event of atrial fibrillation was reported in three patients (2.8%). Zanubrutinib was active and well tolerated in this large, prospectively enrolled treatment cohort of previously untreated patients with del(17p) chronic lymphocytic leukemia/small lymphocytic lymphoma. This trial was registered at ClinicalTrials.gov as #NCT03336333.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Tam, CS
-
Robak, T
-
Ghia, P
-
Kahl, BS
-
Walker, P
-
Janowski, W
-
visa fler...
-
Simpson, D
-
Shadman, M
-
Ganly, PS
-
Laurenti, L
-
Opat, S
-
Tani, M
-
Ciepluch, H
-
Verner, E
-
Simkovi, M
-
Osterborg, A
-
Trneny, M
-
Tedeschi, A
-
Paik, JC
-
Kuwahara, SB
-
Feng, SB
-
Ramakrishnan, V
-
Cohen, A
-
Huang, J
-
Hillmen, P
-
Brown, JR
-
visa färre...
- Artiklar i publikationen
-
Haematologica
- Av lärosätet
-
Karolinska Institutet