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Inhibition of colon...
Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges
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Han, JM (författare)
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Chitu, V (författare)
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Stanley, ER (författare)
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Wszolek, ZK (författare)
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- Karrenbauer, VD (författare)
- Karolinska Institutet
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- Harris, RA (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-04-02
- 2022
- Engelska.
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Ingår i: Cellular and molecular life sciences : CMLS. - : Springer Science and Business Media LLC. - 1420-9071 .- 1420-682X. ; 79:4, s. 219-
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Microglia are specialized dynamic immune cells in the central nervous system (CNS) that plays a crucial role in brain homeostasis and in disease states. Persistent neuroinflammation is considered a hallmark of many neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson's disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS) and primary progressive multiple sclerosis (MS). Colony stimulating factor 1-receptor (CSF-1R) is predominantly expressed on microglia and its expression is significantly increased in neurodegenerative diseases. Cumulative findings have indicated that CSF-1R inhibitors can have beneficial effects in preclinical neurodegenerative disease models. Research using CSF-1R inhibitors has now been extended into non-human primates and humans. This review article summarizes the most recent advances using CSF-1R inhibitors in different neurodegenerative conditions including AD, PD, HD, ALS and MS. Potential challenges for translating these findings into clinical practice are presented.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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