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TNF-alpha: a link b...
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Svenungsson, EKarolinska Institutet
(författare)
TNF-alpha: a link between hypertriglyceridaemia and inflammation in SLE patients with cardiovascular disease
- Artikel/kapitelEngelska2003
Förlag, utgivningsår, omfång ...
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2016-07-02
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SAGE Publications,2003
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1960610
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1960610URI
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https://doi.org/10.1191/0961203303lu412oaDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Patients with systemic lupus erythematosus (SLE) are at high risk of cardiovascular disease (CVD). Tumour necrosisfactor-a (TNF-α) has been implicatedin the pathophysiologicalprocessesof both SLE and CVD. This study focuses on the role of TNF-α and its soluble receptors in SLE-related CVD. In summary, 26 women (52 + 8.2 years) with SLE and a history of CVD (SLE cases)were compared with 26 age-matched women with SLE and no clinical manifestations of CVD (SLE controls) and 26 age-matched population-based control women (population controls). Plasma concentrations of circulating TNF-α, TNF-α receptor 1 (sTNFR1) and TNF-α receptor 2 (sTNFR2) were determined by ELISA. TNF-α, sTNFR1 and sTNFR2 were raised in SLE cases as compared to SLE controls ( P = 0.009; P = 0.001; P = 0.001, respectively), and SLE controls had higher levels than population controls ( P = 0.001; P = 0.02; P = 0.001, respectively). Exclusively in the SLE case group there was a striking positivecorrelationbetweenTNF-α and plasma triglycerides( r = 0.57, P < 0.002), VLDL triglycerides ( r = 0.54, P = 0.004) and VLDL cholesterol ( r = 0.58, P = 0.002). Furthermore, TNF-α correlated with the waist-hip ratio but not with estimated insulin resistance. TNF-α may thus be a major factor in SLE-related CVD acting both by contributing to hypertriglyceridaemia and by promoting atherosclerosis-relatedinflammation. sTNFR1 and sTNFR2 are strongly associated with CVD in SLE but their exact roles in disease development remain to be elucidated.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Fei, GZ
(författare)
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Jensen-Urstad, KKarolinska Institutet
(författare)
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de Faire, UKarolinska Institutet
(författare)
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Hamsten, AKarolinska Institutet
(författare)
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Frostegard, JKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Lupus: SAGE Publications12:6, s. 454-4610961-20331477-0962
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