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Toll-like receptor ...
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Lore, KKarolinska Institutet
(författare)
Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses
- Artikel/kapitelEngelska2003
Förlag, utgivningsår, omfång ...
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The American Association of Immunologists,2003
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:19620548
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http://kipublications.ki.se/Default.aspx?queryparsed=id:19620548URI
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https://doi.org/10.4049/jimmunol.171.8.4320DOI
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Språk:engelska
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Sammanfattning på:engelska
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Optimal Ag targeting and activation of APCs, especially dendritic cells (DCs), are important in vaccine development. In this study, we report the effects of different Toll-like receptor (TLR)-binding compounds to enhance immune responses induced by human APCs, including CD123+ plasmacytoid DCs (PDCs), CD11c+ myeloid DCs (MDCs), monocytes, and B cells. PDCs, which express TLR7 and TLR9, responded to imidazoquinolines (imiquimod and R-848) and to CpG oligodeoxynucleotides stimulation, resulting in enhancement in expression of costimulatory molecules and induction of IFN-α and IL-12p70. In contrast, MDCs, which express TLR3, TLR4, and TLR7, responded to poly(I:C), LPS, and imidazoquinolines with phenotypic maturation and high production of IL-12 p70 without producing detectable IFN-α. Optimally TLR ligand-stimulated PDCs or MDCs exposed to CMV or HIV-1 Ags enhanced autologous CMV- and HIV-1-specific memory T cell responses as measured by effector cytokine production compared with TLR ligand-activated monocytes and B cells or unstimulated PDCs and MDCs. Together, these data show that targeting specific DC subsets using TLR ligands can enhance their ability to activate virus-specific T cells, providing information for the rational design of TLR ligands as adjuvants for vaccines or immune modulating therapy.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Betts, MR
(författare)
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Brenchley, JM
(författare)
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Kuruppu, J
(författare)
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Khojasteh, S
(författare)
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Perfetto, S
(författare)
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Roederer, M
(författare)
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Seder, RA
(författare)
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Koup, RA
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of immunology (Baltimore, Md. : 1950): The American Association of Immunologists171:8, s. 4320-43280022-17671550-6606
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