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Association between...
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Moridi, TKarolinska Institutet
(författare)
Association between brain volume and disability over time in multiple sclerosis
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-12-18
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SAGE Publications,2022
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:236570871
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http://kipublications.ki.se/Default.aspx?queryparsed=id:236570871URI
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https://doi.org/10.1177/20552173221144230DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Most previous multiple sclerosis (MS) brain atrophy studies using MS impact scale 29 (MSIS-29) or symbol digit modalities test (SDMT) have been cross-sectional with limited sets of clinical outcomes. Objectives To investigate which brain and lesion volume metrics show the strongest long-term associations with the expanded disability status scale (EDSS), SDMT, and MSIS-29, and whether MRI-clinical associations vary with age. Methods We acquired MRI and clinical data from a real-world Swedish MS cohort. FreeSurfer and SPM Lesion Segmentation Tool were used to obtain brain parenchymal, cortical and subcortical grey matter, thalamic and white matter fractions as well as T1- and T2-lesion volumes. Mixed-effects and rolling regression models were used in the statistical analyses. Results We included 989 persons with MS followed for a median of 9.3 (EDSS), 10.1 (SDMT), and 9.3 (MSIS-29) years, respectively. In a cross-sectional analysis, the strength of the associations of the MRI metrics with the EDSS and MSIS-29 was found to drastically increase after 40–50 years of age. Low baseline regional grey matter fractions were associated with longitudinal increase of EDSS and physical MSIS-29 scores and decrease in SDMT scores and these atrophy measures were stronger predictors than the lesion volumes. Conclusions The strength of MRI-clinical associations increase with age. Grey matter volume fractions are stronger predictors of long-term disability measures than lesion volumes.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Stawiarz, LKarolinska Institutet
(författare)
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McKay, KAKarolinska Institutet
(författare)
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Ineichen, BV
(författare)
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Ouellette, RKarolinska Institutet
(författare)
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Ferreira, DKarolinska Institutet
(författare)
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Muehlboeck, JSKarolinska Institutet
(författare)
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Westman, EKarolinska Institutet
(författare)
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Kockum, IKarolinska Institutet
(författare)
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Olsson, TKarolinska Institutet
(författare)
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Piehl, F
(författare)
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Hillert, JKarolinska Institutet
(författare)
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Manouchehrinia, AKarolinska Institutet
(författare)
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Granberg, TKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Multiple sclerosis journal - experimental, translational and clinical: SAGE Publications8:4, s. 20552173221144230-2055-2173
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Till lärosätets databas
- Av författaren/redakt...
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Moridi, T
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Stawiarz, L
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McKay, KA
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Ineichen, BV
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Ouellette, R
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Ferreira, D
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visa fler...
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Muehlboeck, JS
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Westman, E
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Kockum, I
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Olsson, T
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Piehl, F
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Hillert, J
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Manouchehrinia, ...
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Granberg, T
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visa färre...
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Multiple scleros ...
- Av lärosätet
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Karolinska Institutet