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Sökning: onr:"swepub:oai:DiVA.org:kth-353424" > Acquisition Duratio...

  • Nilsson, TedKarolinska Institutet (författare)

Acquisition Duration Optimization Using Visual Grading Regression in [68Ga]FAPI-46 PET Imaging of Oncologic Patients

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Society of Nuclear Medicine,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-353424
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-353424URI
  • https://doi.org/10.2967/jnmt.123.267156DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:238627014URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Imported from Scopus. VERIFY.
  • Fibroblast activation protein is a promising target for oncologic molecular imaging with radiolabeled fibroblast activation protein inhibitors (FAPI) in a large variety of cancers. However, there are yet no published recommendations on how to set up an optimal imaging protocol for FAPI PET/CT. It is important to optimize the acquisition duration and strive toward an acquisition that is sufficiently short while simultaneously providing sufficient image quality to ensure a reliable diagnosis. The aim of this study was to evaluate the feasibility of reducing the acquisition duration of [68Ga]FAPI-46 imaging while maintaining satisfactory image quality, with certainty that the radiologist's ability to make a clinical diagnosis would not be affected. Methods: [68Ga]FAPI-46 PET/CT imaging was performed on 10 patients scheduled for surgical resection of suspected pancreatic cancer, 60 min after administration of 3.6 ± 0.2 MBq/kg. The acquisition time was 4 min/bed position, and the raw PET data were statistically truncated and reconstructed to represent images with an acquisition duration of 1, 2, and 3 min/bed position, additional to the reference images of 4 min/bed position. Four image quality criteria that focused on the ability to distinguish specific anatomic details, as well as perceived image noise and overall image quality, were scored on a 4-point Likert scale and analyzed with mixed-effects ordinal logistic regression. Results: A trend toward increasing image quality scores with increasing acquisition duration was observed for all criteria. For the overall image quality, there was no significant difference between 3 and 4 min/bed position, whereas 1 and 2 min/bed position were rated significantly (P < 0.05) lower than 4 min/bed position. For the other criteria, all images with a reduced acquisition duration were rated significantly inferior to images obtained at 4 min/bed position. Conclusion: The acquisition duration can be reduced from 4 to 3 min/bed position while maintaining satisfactory image quality. Reducing the acquisition duration to 2 min/bed position or lower is not recommended since it results in inferior-quality images so noisy that clinical interpretation is significantly disrupted.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Rasinski, PawelKarolinska Institutet (författare)
  • Smedby, Örjan,Professor,1956-KTH,Medicinsk avbildning(Swepub:kth)u1vc2uzb (författare)
  • Af Burén, SiriKarolinska Institutet (författare)
  • Sparrelid, ErnestoKarolinska Institutet,Department of Upper Gastrointestinal Diseases (författare)
  • Löhr, J. MatthiasKarolinska Institutet,Department of Upper Gastrointestinal Diseases (författare)
  • Tran, Thuy A.Karolinska Institutet,Department of Radiopharmacy, Karolinska University Hospital, Stockholm, Sweden; and (författare)
  • Blomgren, August (författare)
  • Tzortzakakis, AntoniosKarolinska Institutet (författare)
  • Axelsson, RimmaKarolinska Institutet (författare)
  • Holstensson, MariaKarolinska Institutet,Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden; (författare)
  • Karolinska InstitutetMedicinsk avbildning (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Nuclear Medicine Technology: Society of Nuclear Medicine52:3, s. 221-2280091-49161535-5675

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