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Acquisition Duratio...
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Nilsson, TedKarolinska Institutet
(författare)
Acquisition Duration Optimization Using Visual Grading Regression in [68Ga]FAPI-46 PET Imaging of Oncologic Patients
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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Society of Nuclear Medicine,2024
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LIBRIS-ID:oai:DiVA.org:kth-353424
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-353424URI
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https://doi.org/10.2967/jnmt.123.267156DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:238627014URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Imported from Scopus. VERIFY.
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Fibroblast activation protein is a promising target for oncologic molecular imaging with radiolabeled fibroblast activation protein inhibitors (FAPI) in a large variety of cancers. However, there are yet no published recommendations on how to set up an optimal imaging protocol for FAPI PET/CT. It is important to optimize the acquisition duration and strive toward an acquisition that is sufficiently short while simultaneously providing sufficient image quality to ensure a reliable diagnosis. The aim of this study was to evaluate the feasibility of reducing the acquisition duration of [68Ga]FAPI-46 imaging while maintaining satisfactory image quality, with certainty that the radiologist's ability to make a clinical diagnosis would not be affected. Methods: [68Ga]FAPI-46 PET/CT imaging was performed on 10 patients scheduled for surgical resection of suspected pancreatic cancer, 60 min after administration of 3.6 ± 0.2 MBq/kg. The acquisition time was 4 min/bed position, and the raw PET data were statistically truncated and reconstructed to represent images with an acquisition duration of 1, 2, and 3 min/bed position, additional to the reference images of 4 min/bed position. Four image quality criteria that focused on the ability to distinguish specific anatomic details, as well as perceived image noise and overall image quality, were scored on a 4-point Likert scale and analyzed with mixed-effects ordinal logistic regression. Results: A trend toward increasing image quality scores with increasing acquisition duration was observed for all criteria. For the overall image quality, there was no significant difference between 3 and 4 min/bed position, whereas 1 and 2 min/bed position were rated significantly (P < 0.05) lower than 4 min/bed position. For the other criteria, all images with a reduced acquisition duration were rated significantly inferior to images obtained at 4 min/bed position. Conclusion: The acquisition duration can be reduced from 4 to 3 min/bed position while maintaining satisfactory image quality. Reducing the acquisition duration to 2 min/bed position or lower is not recommended since it results in inferior-quality images so noisy that clinical interpretation is significantly disrupted.
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Rasinski, PawelKarolinska Institutet
(författare)
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Smedby, Örjan,Professor,1956-KTH,Medicinsk avbildning(Swepub:kth)u1vc2uzb
(författare)
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Af Burén, SiriKarolinska Institutet
(författare)
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Sparrelid, ErnestoKarolinska Institutet,Department of Upper Gastrointestinal Diseases
(författare)
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Löhr, J. MatthiasKarolinska Institutet,Department of Upper Gastrointestinal Diseases
(författare)
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Tran, Thuy A.Karolinska Institutet,Department of Radiopharmacy, Karolinska University Hospital, Stockholm, Sweden; and
(författare)
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Blomgren, August
(författare)
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Tzortzakakis, AntoniosKarolinska Institutet
(författare)
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Axelsson, RimmaKarolinska Institutet
(författare)
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Holstensson, MariaKarolinska Institutet,Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden;
(författare)
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Karolinska InstitutetMedicinsk avbildning
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Nuclear Medicine Technology: Society of Nuclear Medicine52:3, s. 221-2280091-49161535-5675
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Nilsson, Ted
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Rasinski, Pawel
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Smedby, Örjan, P ...
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Af Burén, Siri
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Sparrelid, Ernes ...
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Löhr, J. Matthia ...
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visa fler...
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Tran, Thuy A.
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Blomgren, August
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Tzortzakakis, An ...
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Axelsson, Rimma
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Holstensson, Mar ...
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