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Association between...
Association between parental psychiatric disorders and risk of offspring autism spectrum disorder: a Swedish and Finnish population-based cohort study
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- Yin, Weiyao (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Pulakka, Anna (författare)
- Finnish Inst Hlth & Welf, Finland; Finnish Inst Hlth & Welf, Finland; Univ Oulu, Finland
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- Reichenberg, Abraham (författare)
- Icahn Sch Med Mt Sinai, NY USA; Icahn Sch Med Mt Sinai, NY USA; Icahn Sch Med Mt Sinai, NY USA
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- Kolevzon, Alexander (författare)
- Icahn Sch Med Mt Sinai, NY USA; Icahn Sch Med Mt Sinai, NY USA
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- Ludvigsson, Jonas F. (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Orebro Univ Hosp, Sweden
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- Risnes, Kari (författare)
- NTNU, Norway; St Olavs Univ Hosp, Norway
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- Lahti-Pulkkinen, Marius (författare)
- Finnish Inst Hlth & Welf, Finland; Finnish Inst Hlth & Welf, Finland; Univ Helsinki, Finland
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- Persson, Martina (författare)
- Karolinska Inst, Sweden; Karolinska Inst, Sweden; Sachsska Childrens & Youth Hosp, Sweden
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- Silverman, Michael E. (författare)
- Icahn Sch Med Mt Sinai, NY USA
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- Ådén, Ulrika (författare)
- Karolinska Institutet,Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus,Karolinska Inst, Sweden
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- Kajantie, Eero (författare)
- Finnish Inst Hlth & Welf, Finland; Finnish Inst Hlth & Welf, Finland; Oulu Univ Hosp, Finland; Univ Oulu, Finland
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- Sandin, Sven (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Icahn Sch Med Mt Sinai, NY USA; Icahn Sch Med Mt Sinai, NY USA
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(creator_code:org_t)
- ELSEVIER, 2024
- 2024
- Engelska.
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Ingår i: The Lancet Regional Health. - : ELSEVIER. - 2666-7762. ; 40
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Roughly more than one in six adults worldwide suffer from psychiatric conditions. Sporadic studies have associated parental psychiatric disorders with autism spectrum disorder in offspring. Comprehensively examining the association between parental psychiatric disorders and offspring autism spectrum disorder is needed to guide health policies, and to inform etiologic studies. Methods We included all children born in Sweden and Finland 1997 - 2016. Diagnoses were clinically ascertained from National Registers through 2017. We calculated adjusted hazard ratios (aHRs) and 95% con fi dence intervals (CIs) for autism spectrum disorder in offspring of fathers and mothers with psychiatric disorders, in both parents jointly and across co-occurring conditions. Findings Among 2,505,842 children, 33,612 were diagnosed with autism spectrum disorder, of which 20% had a parent with psychiatric disorders. The risk of autism spectrum disorder was increased across all psychiatric disorders in fathers (Sweden: aHR = 2.02, 95% CI = 1.92 - 2.12; Finland: aHR = 1.63, 95% CI = 1.50 - 1.77), mothers (Sweden: aHR = 2.34, 95% CI = 2.24 - 2.43; Finland aHR = 2.12, 95% CI = 1.92 - 2.28), or both parents (Sweden: aHR = 3.76, 95% CI = 3.48 - 4.07; Finland aHR = 3.61, 95% CI = 3.20 - 4.07), compared to neither parents. Co -occurrence of parental psychiatric disorders further increased risk (e.g., Sweden: for one, two or >= three different diagnostic categories compared to no diagnosis, in fathers aHR = 1.81, 2.07, 2.52; in mothers aHR = 2.05, 2.63, 3.57). Interpretation Psychiatric disorders in both parents conveyed the highest risk of offspring autism spectrum disorder, followed by mothers and then fathers. The risk increased with number of co-occurring disorders. All parental psychiatric disorders were associated with increased the risk of autism spectrum disorder. To reliably assess the risk of autism spectrum disorder in children, a comprehensive history incorporating the full range of parental psychiatric disorders is needed beyond solely focusing on familial autism spectrum disorder.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Autism; Mental illness; Family risk; Cohort; Epidemiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Yin, Weiyao
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Pulakka, Anna
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Reichenberg, Abr ...
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Kolevzon, Alexan ...
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Ludvigsson, Jona ...
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Risnes, Kari
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Lahti-Pulkkinen, ...
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Persson, Martina
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Silverman, Micha ...
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Ådén, Ulrika
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Kajantie, Eero
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Sandin, Sven
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
- Artiklar i publikationen
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The Lancet Regio ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet