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Sökning: onr:"swepub:oai:research.chalmers.se:004d517b-5e31-4f75-bc18-831bc02c56b0" > Immunoglobulin G N-...

  • Birukov, AnnaHarvard School of Public Health, United States (författare)

Immunoglobulin G N-Glycosylation Signatures in Incident Type 2 Diabetes and Cardiovascular Disease

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-10-25
  • American Diabetes Association,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:research.chalmers.se:004d517b-5e31-4f75-bc18-831bc02c56b0
  • https://research.chalmers.se/publication/533138URI
  • https://doi.org/10.2337/dc22-0833DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • OBJECTIVE N-glycosylation is a functional posttranslational modification of immunoglobulins (Igs). We hypothesized that specific IgG N-glycans are associated with incident type 2 diabetes and cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS We performed case-cohort studies within the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam cohort (2,127 in the type 2 diabetes subcohort [741 incident cases]; 2,175 in the CVD subcohort [417 myocardial infarction and stroke cases]). Relative abundances of 24 IgG N-glycan peaks (IgG-GPs) were measured by ultraperformance liquid chromatog-raphy, and eight glycosylation traits were derived based on structural similarity. End point–associated IgG-GPs were preselected with fractional polynomials, and prospective associations were estimated in confounder-adjusted Cox models. Diabetes risk associations were validated in three independent studies. RESULTS After adjustment for confounders and multiple testing correction, IgG-GP7, IgG-GP8, IgG-GP9, IgG-GP11, and IgG-GP19 were associated with type 2 diabetes risk. A score based on these IgG-GPs was associated with a higher diabetes risk in EPIC-Potsdam and independent validation studies (843 total cases, 3,149 total non-cases, pooled estimate per SD increase 1.50 [95% CI 1.37–1.64]). Associations of IgG-GPs with CVD risk differed between men and women. In women, IgG-GP9 was inversely associated with CVD risk (hazard ratio [HR] per SD 0.80 [95% CI 0.65–0.98]). In men, a weighted score based on IgG-GP19 and IgG-GP23 was associated with higher CVD risk (HR per SD 1.47 [95% CI 1.20–1.80]). In addition, several derived traits were associated with cardiometabolic disease incidence. CONCLUSIONS Selected IgG N-glycans are associated with cardiometabolic risk beyond classic risk factors, including clinical biomarkers.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Plavćsa, Branimir (författare)
  • Eichelmann, Fabian (författare)
  • Kuxhaus, Olga (författare)
  • Hoshi, Rosangela AkemiHarvard Medical School (författare)
  • Rudman, Najda (författare)
  • Stambuk, Tamara (författare)
  • Trbojevićc-Akmaćcićc, Irena (författare)
  • Schiborn, Catarina (författare)
  • Morze, JakubHarvard School of Public Health, United States,University of Warmia and Mazury in Olsztyn (författare)
  • Mihelćcićc, Matea (författare)
  • Cindrićc, Ana (författare)
  • Liu, YanyanHarvard Medical School (författare)
  • Demler, OlgaHarvard Medical School,Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH) (författare)
  • Perola, MarkusHelsingin Yliopisto,University of Helsinki (författare)
  • Mora, SamiaHarvard Medical School (författare)
  • Schulze, Matthias B.Universität Potsdam,University of Potsdam (författare)
  • Lauc, Gordan (författare)
  • Wittenbecher, Clemens,1981Harvard School of Public Health, United States,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)clemensw (författare)
  • Harvard School of Public Health, United StatesHarvard Medical School (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetes Care: American Diabetes Association45:11, s. 2729-27361935-55480149-5992

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