Sökning: onr:"swepub:oai:research.chalmers.se:bf8e2e39-b40b-4925-9d7e-0ec47e8aefc3" >
High energy gas clu...
High energy gas cluster ions for organic and biological analysis by time-of-flight secondary ion mass spectrometry
-
- Angerer, Tina B., 1987 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
Blenkinsopp, Paul (författare)
-
- Fletcher, John, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
-
Ingår i: International Journal of Mass Spectrometry. - : Elsevier BV. - 1387-3806 .- 1873-2798. ; 377, s. 591-598
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://doi.org/10.1...
-
https://research.cha...
-
https://gup.ub.gu.se...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- There is considerable excitement surrounding the application of gas cluster ion beams (GCIBs) for SIMS analysis in order to study organic materials and biological samples such as cells and tissues. These ion beams, that often comprise several thousand argon atoms in the primary ion, have been used mainly for the etching of organic materials to remove damage from the surface allowing molecular depth profiling experiments to be performed. The energy of the ion beam is normally 2–20 keV. There have been relatively few studies reported on the use of GCIB as analysis beams, due to difficulties related to fast pulsing and focusing of the beam along with the sometimes low ionisation efficiency. In this study, we report on the use of a new higher energy (40 keV) GCIB operated in a continuous mode. When compared to lower energies depth profiles on thin films of Irganox 1010 show an increase in sputter yield signal while fragmentation, damage accumulation and ionisation efficiency remains unchanged. Experiments on brain tissues show increased signal levels especially for higher mass secondary ions (m/z 500+) in comparison to C60+ at 40 keV and Ar4000+ at 20 keV impact energy. The use of higher energies facilitates better focusing of the primary ion beam as demonstrated here on a human hair sample where we achieve a spatial resolution of
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
Nyckelord
- Gas cluster ion beams
- Cholestero
- Imaging
- Irganox
- Mouse brain
- High energy
- Time-of-flight secondary ion mass spectrometry (ToF-SIMS)
- GCIB
- Time-of-flight secondary ion mass spectrometry (ToF-SIMS); Imaging; Gas cluster ion beams; GCIB; High energy; Mouse brain; Irganox; Cholestero
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas