Sökning: onr:"swepub:oai:research.chalmers.se:ee2f2856-34a9-41bf-84cd-63b3ba0d0253" >
Proteomic Analysis ...
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Fuvesi, J.Uppsala universitet,Analytisk kemi
(författare)
Proteomic Analysis of Cerebrospinal Fluid in a Fulminant Case of Multiple Sclerosis
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2012-06-21
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MDPI AG,2012
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:research.chalmers.se:ee2f2856-34a9-41bf-84cd-63b3ba0d0253
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https://research.chalmers.se/publication/163004URI
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https://doi.org/10.3390/ijms13067676DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-176842URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Multiple Sclerosis (MS) is a chronic disease, but in rare fulminant cases rapid progression may lead to death shortly after diagnosis. Currently there is no diagnostic test to predict disease course. The aim of this study was to identify potential biomarkers/proteins related to rapid progression. We present the case history of a 15-year-old male MS patient. Cerebrospinal fluid (CSF) was taken at diagnosis and at the time of rapid progression leading to the patient's death. Using isobaric tag labeling and nanoflow liquid chromatography in conjunction with matrix assisted laser desorption/ionization time of flight tandem mass spectrometry we quantitatively analyzed the protein content of two CSF samples from the patient with fulminant MS as well as one relapsing-remitting (RR) MS patient and one control headache patient, whose CSF analysis was normal. Seventy-eight proteins were identified and seven proteins were found to be more abundant in both fulminant MS samples but not in the RR MS sample compared to the control. These proteins are involved in the immune response, blood coagulation, cell proliferation and cell adhesion. In conclusion, in this pilot study we were able to show differences in the CSF proteome of a rapidly progressing MS patient compared to a more typical clinical form of MS and a control subject.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hanrieder, Jörg,1980Uppsala universitet,Analytisk kemi(Swepub:uu)jorha165
(författare)
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Bencsik, K.University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary
(författare)
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Rajda, C.University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary AND Department of Clinical Neurophysiology, Danish Epilepsy Centre, Denmark
(författare)
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Kovacs, S. K.University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Pathology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary
(författare)
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Kaizer, L.University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Pathology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary
(författare)
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Beniczky, S.University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary AND Department of Clinical Neurophysiology, Danish Epilepsy Centre, Denmark
(författare)
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Vecsei, L.University of Szeged,University of Szeged / Szegedi Tudományegyetem,Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged AND Neuroscience Research Group, Hungarian Academy of Sciences, University of Szeged, Hungary
(författare)
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Bergquist, JonasUppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab(Swepub:uu)jbe25356
(författare)
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Uppsala universitetAnalytisk kemi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Molecular Sciences: MDPI AG13:6, s. 7676-76931661-65961422-0067
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Fuvesi, J.
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Hanrieder, Jörg, ...
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Bencsik, K.
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Rajda, C.
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Kovacs, S. K.
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Kaizer, L.
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visa fler...
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Beniczky, S.
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Vecsei, L.
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Bergquist, Jonas
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visa färre...
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- NATURVETENSKAP
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