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Sökning: onr:"swepub:oai:research.chalmers.se:f873e566-cf05-4094-bbb2-c449da3aeb08" > The Impact of Acute...

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FältnamnIndikatorerMetadata
00005688naa a2200637 4500
001oai:research.chalmers.se:f873e566-cf05-4094-bbb2-c449da3aeb08
003SwePub
008230331s2023 | |||||||||||000 ||eng|
0247 a https://research.chalmers.se/publication/5352282 URI
0247 a https://doi.org/10.1210/clinem/dgad0312 DOI
040 a (SwePub)cth
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Vernardis,u The Francis Crick Institute4 aut
2451 0a The Impact of Acute Nutritional Interventions on the Plasma Proteome
264 c 2023-01-20
264 1b The Endocrine Society,c 2023
338 a electronic2 rdacarrier
520 a Context: Humans respond profoundly to changes in diet, while nutrition and environment have a great impact on population health. It is therefore important to deeply characterize the human nutritional responses. Objective: Endocrine parameters and the metabolome of human plasma are rapidly responding to acute nutritional interventions such as caloric restriction or a glucose challenge. It is less well understood whether the plasma proteome would be equally dynamic, and whether it could be a source of corresponding biomarkers. Methods: We used high-throughput mass spectrometry to determine changes in the plasma proteome of i) 10 healthy, young, male individuals in response to 2 days of acute caloric restriction followed by refeeding; ii) 200 individuals of the Ely epidemiological study before and after a glucose tolerance test at 4 time points (0, 30, 60, 120 minutes); and iii) 200 random individuals from the Generation Scotland study. We compared the proteomic changes detected with metabolome data and endocrine parameters. Results: Both caloric restriction and the glucose challenge substantially impacted the plasma proteome. Proteins responded across individuals or in an individual-specific manner. We identified nutrient-responsive plasma proteins that correlate with changes in the metabolome, as well as with endocrine parameters. In particular, our study highlights the role of apolipoprotein C1 (APOC1), a small, understudied apolipoprotein that was affected by caloric restriction and dominated the response to glucose consumption and differed in abundance between individuals with and without type 2 diabetes. Conclusion: Our study identifies APOC1 as a dominant nutritional responder in humans and highlights the interdependency of acute nutritional response proteins and the endocrine system.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653 a oral glucose tolerance test
653 a type 2 diabetes
653 a caloric restriction
653 a plasma proteomics
653 a APOC1
7001 a Demichev, Vadimu Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut
7001 a Lemke, Oliveru Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut
7001 a Gruening, Nana-Mariau Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut
7001 a Messner, Christophu The Francis Crick Institute4 aut
7001 a White, Mattu The Francis Crick Institute4 aut
7001 a Pietzner, Maiku Charité Universitätsmedizin Berlin,Charité University Medicine Berlin,University Of Cambridge4 aut
7001 a Peluso, Alinau The Francis Crick Institute4 aut
7001 a Collet, Tinh-Haiu Université de Genève,University of Geneva,University Of Cambridge4 aut
7001 a Henning, Elanau University Of Cambridge4 aut
7001 a Gille, Christophu Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut
7001 a Campbell, Archieu University of Edinburgh4 aut
7001 a Hayward, Carolineu University of Edinburgh4 aut
7001 a Porteous, David J.u University of Edinburgh4 aut
7001 a Marioni, Riccardo E.u University of Edinburgh4 aut
7001 a Muelleder, Michaelu Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut
7001 a Zelezniak, Aleksej,d 1984u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)alezel
7001 a Langenberg, Claudiau University Of Cambridge,Queen Mary University of London,Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut
7001 a Farooqi, I. Sadafu University Of Cambridge4 aut
7001 a Ralser, Markusu The Francis Crick Institute,Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut
7102 a The Francis Crick Instituteb Charité Universitätsmedizin Berlin4 org
7730 t Journal of Clinical Endocrinology and Metabolismd : The Endocrine Societyg 108:8, s. 2087-2098q 108:8<2087-2098x 1945-7197x 0021-972X
8564 u https://research.chalmers.se/publication/535228/file/535228_Fulltext.pdfx primaryx freey FULLTEXT
8564 8u https://research.chalmers.se/publication/535228
8564 8u https://doi.org/10.1210/clinem/dgad031

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