SwePub - sökning: L773:9781071611890 OR L773:978...

Träfflista för sökning "L773:9781071611890 OR L773:9781071611920 OR L773:9781071611906 "

Sökning: L773:9781071611890 OR L773:9781071611920 OR L773:9781071611906

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
1.	Wu, Yao-Wen, Professor (författare) Spatiotemporal Imaging of Small GTPase Activity Using Conformational Sensors for GTPase Activity (COSGA) 2021 Ingår i: Ras Activity and Signaling. - New York, NY : Humana Press. - 9781071611890 - 9781071611920 - 9781071611906 ; , s. 259-267 Bokkapitel (refereegranskat)abstract Small GTPases cycle between active GTP bound and inactive GDP bound forms in live cells. They act as molecular switches and regulate diverse cellular processes at different times and locations in the cell. Spatiotemporal visualization of their activity provides important insights into dynamics of cellular signaling. Conformational sensors for GTPase activity (COSGAs) are based on the conserved GTPase fold and have been used as a versatile approach for imaging small GTPase activity in the cell. Conformational changes upon GDP/GTP binding can be visualized directly in solution, on beads, or in live cells using COSGA by fluorescence lifetime imaging microscopy (FLIM) technique. Herein, we describe the construction of COSGA for imaging K-Ras GTPase activity in live cells.

Skapa referenser, mejla, bekava och länka

Träfflista för sökning "L773:9781071611890 OR L773:9781071611920 OR L773:9781071611906 "