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- Koeck, Philip J. B., et al.
(author)
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3D-correlation-averaging for membrane-protein-crystals
- 2008
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In: EMC 2008 14th European Microscopy Congress. - Berlin, Heidelberg : Springer Berlin Heidelberg. ; , s. 55-56
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Conference paper (peer-reviewed)abstract
- Few 2-dimensional protein crystals can be used to determine high-resolution structures, whereas most electron crystallography projects remain at a resolution around 10 Ångström. This might be partly due to lack of flatness of many two-dimensional crystals [1]. We have investigated this problem and suggest single particle projection matching (3D-correlation averaging) of locally averaged unit cells to improve the quality of three-dimensional maps. Theoretical considerations and tests on simulated data demonstrate the feasibility of this refinement method [2].
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