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- Sarneel, Judith M., et al.
(författare)
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Reading tea leaves worldwide : decoupled drivers of initial litter decomposition mass-loss rate and stabilization
- 2024
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Ingår i: Ecology Letters. - : John Wiley & Sons. - 1461-023X .- 1461-0248. ; 27:5
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Tidskriftsartikel (refereegranskat)abstract
- The breakdown of plant material fuels soil functioning and biodiversity. Currently, process understanding of global decomposition patterns and the drivers of such patterns are hampered by the lack of coherent large-scale datasets. We buried 36,000 individual litterbags (tea bags) worldwide and found an overall negative correlation between initial mass-loss rates and stabilization factors of plant-derived carbon, using the Tea Bag Index (TBI). The stabilization factor quantifies the degree to which easy-to-degrade components accumulate during early-stage decomposition (e.g. by environmental limitations). However, agriculture and an interaction between moisture and temperature led to a decoupling between initial mass-loss rates and stabilization, notably in colder locations. Using TBI improved mass-loss estimates of natural litter compared to models that ignored stabilization. Ignoring the transformation of dead plant material to more recalcitrant substances during early-stage decomposition, and the environmental control of this transformation, could overestimate carbon losses during early decomposition in carbon cycle models.
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- Bejarano, J., et al.
(författare)
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Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches
- 2018
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Ingår i: Theranostics. - : Ivyspring International Publisher. - 1838-7640. ; 8:17, s. 4710-4732
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Tidskriftsartikel (refereegranskat)abstract
- Cardiovascular diseases are the leading cause of death worldwide. Despite preventive efforts, early detection of atherosclerosis, the common pathophysiological mechanism underlying cardiovascular diseases remains elusive, and overt coronary artery disease or myocardial infarction is often the first clinical manifestation. Nanoparticles represent a novel strategy for prevention, diagnosis, and treatment of atherosclerosis, and new multifunctional nanoparticles with combined diagnostic and therapeutic capacities hold the promise for theranostic approaches to this disease. This review focuses on the development of nanosystems for therapy and diagnosis of subclinical atherosclerosis, coronary artery disease, and myocardial infarction and the evolution of nanosystems as theranostic tools. We also discuss the use of nanoparticles in noninvasive imaging, targeted drug delivery, photothermal therapies together with the challenges faced by nanosystems during clinical translation.
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- Cervenak, L, et al.
(författare)
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Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10
- 2000
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Ingår i: Blood. - 0006-4971. ; 96:7, s. 73-2568
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Tidskriftsartikel (refereegranskat)abstract
- Because of its immunosuppressive properties, interleukin-10 (IL-10) is thought to play an important role in a number of human disease states, including inflammation, autoimmunity, and transplant rejection. In this study, we demonstrate that introduction of human or viral IL-10 genes into Burkitt's lymphoma cells markedly reduced their ability to grow as subcutaneous (sc) tumors in SCID mice. In vivo assays for angiogenesis revealed an inhibition of the angiogenic capacity of the IL-10-transfected lines. Recombinant human IL-10 abolished and viral IL-10 reduced vascular endothelial growth factor (VEGF)-165-induced neovascularization. Furthermore, IL-10 blocked the VEGF- and fibroblast growth factor (FGF)-2-induced proliferation of microvascular endothelial cells in vitro. The current observations suggest a direct role for IL-10 in the prevention of angiogenesis in human lymphoid malignancies.
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- Bejarano-Arias, Ingrid, et al.
(författare)
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Testing the Applicability of Quartz and Feldspar for Luminescence Dating of Pleistocene Alluvial Sediments in the Tatra Mountain Foothills, Slovakia
- 2023
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Ingår i: Geochronometria. - 1733-8387. ; 50:1, s. 50-80
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Tidskriftsartikel (refereegranskat)abstract
- Luminescence dating is a widely used method in combination with sedimentological analysis for reconstructing the landscape development of the Quaternary period. In this study, quartz and K-feldspar measurements were used to evaluate the luminescence characteristics with the aim of dating the deposits. The sediments were sampled from an abandoned gravel pit in the Biely Váh valley and eight sites in the lower part of the Velická dolina valley, High Tatra Mountains, Slovakia. Optically stimulated luminescence (OSL) showed that quartz had an unstable weak signal, and standard single aliquot regeneration (SAR) dose estimates were unreliable, as were doses from pulsed OSL and differential OSL. Infrared (IR50) and post-IR IR225 stimulation (pIRIR225) signals from K-feldspar grains, on the other hand, gave stronger signals but were, to various extents, influenced by incomplete bleaching, fading and uncertainty due to high (>2D0) doses. We find the uncorrected pIRIR225 ages most reliable, though modern analogues indicate that there may be significant residual from incomplete bleaching for some of the samples. The results of the luminescence analyses, ages and sedimentology are put in the context of landscape dynamics and compared to the known glacial history of the Tatra Mountains.
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- Bejarano, Sonia, et al.
(författare)
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The shape of success in a turbulent world : wave exposure filtering of coral reef herbivory
- 2017
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Ingår i: Functional Ecology. - : Wiley. - 0269-8463 .- 1365-2435. ; 31:6, s. 1312-1324
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Forskningsöversikt (refereegranskat)abstract
- While environmental filters are well-known factors influencing community assembly, the extent to which these modify species functions, and entire ecosystem processes, is poorly understood. Focusing on a high-diversity system, we ask whether environmental filtering has ecosystem-wide effects beyond community assembly. We characterise a coral reef herbivorous fish community for swimming performance based on ten functional traits derived from fish morphology. We then investigate whether wave exposure modifies the functional make-up of herbivory, and the absolute and relative feeding frequency of distinct feeding functional groups. Herbivorous fish species conformed to either laterally compressed or fusiform body plans, which differ in their morphological design to minimise drag. High wave exposure selectively limited the feeding function of the deepest body shapes with highest caudal thrust efficiency, and favoured fusiform bodies irrespective of pectoral fin shape. Traditionally recognised herbivore feeding functional groups (i.e. grazers-detritivores and scrapers-small excavators) differed in swimming performance, and in their capacity to feed consistently across levels of wave exposure. We therefore emphasise the distinctness of their ecological niche and functional complementarity. Species within the same feeding functional group also had contrasting responses to wave exposure. We thereby reveal a further ecological dimension of niche partitioning, and reiterate the risk of assuming functional redundancy among species with a common feeding mode. Contrasting responses of species within feeding functional roles (i.e. response diversity) allowed the preservation of critical trophic functions throughout the gradient (e.g. macroalgal browsing), and likely explained why overall levels of herbivory were robust to filtering. Whether ecosystem functioning will remain robust under the additive effects of environmental stress and human-induced disturbances remains to be tested.
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