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- Sieberts, SK, et al.
(författare)
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Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
- 2016
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 12460-
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Tidskriftsartikel (refereegranskat)abstract
- Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment of the utility of SNP data for predicting anti-TNF treatment efficacy in RA patients was performed in the context of a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled the comparative evaluation of predictions developed by 73 research groups using the most comprehensive available data and covering a wide range of state-of-the-art modelling methodologies. Despite a significant genetic heritability estimate of treatment non-response trait (h2=0.18, P value=0.02), no significant genetic contribution to prediction accuracy is observed. Results formally confirm the expectations of the rheumatology community that SNP information does not significantly improve predictive performance relative to standard clinical traits, thereby justifying a refocusing of future efforts on collection of other data.
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2. |
- Parvini, P, et al.
(författare)
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Influence of loading and grafting on hard- and soft tissue healing at immediately placed implants : An experimental study in minipigs
- 2023
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Ingår i: Journal of Clinical Periodontology. - : Wiley-Blackwell. - 0303-6979 .- 1600-051X. ; 50:2, s. 232-241
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To histologically evaluate the influence of i) loading and ii) grafting on osseointegration and peri-implant soft tissue healing at immediately placed, self- cutting progressive tissue- level implants (TLX) in a minipig model.MATERIAL & METHODS: TLX implants (n=56) were immediately placed following the extraction of the mandibular first and second premolars, bilaterally, in a total of n=14 minipigs. In each animal, the implant sites were allocated to the following four groups: 1. unloaded with simultaneous grafting using a bovine bone mineral; 2. unloaded without grafting; 3. loaded with simultaneous grafting; 4. loaded without grafting. Histomorphometrical assessments at 4 and 12 weeks (n=7 animals each) included primary (i.e. bone-to-implant contact - BIC) and secondary outcome measures (e.g. first bone-to-implant contact - fBIC, junctional epithelium length- JE, connective tissue contact length - CTC, biological width - BW = JE + CTC).RESULTS: At 4 weeks, mean BIC values ranged from 74.5 ± 11.6% in group 2 to 83.8 ± 13.3% in group 1, and, at 12 weeks, from 75.5% ± 7.9% in group 2 to 79.9 ± 8.6% in group 1, respectively. Multivariate linear mixed regression did not reveal any associations between BIC and implant loading or grafting at 4 and 12 weeks. At 12 weeks, significantly higher fBIC values were noted in group 2 when compared with group 1. All groups showed comparable JE, CTC and BW values.CONCLUSIONS: Implant loading and grafting had no major effects on osseointegration and peri-implant soft tissue healing at TLX implants.
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