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1.	Pedersen, TR, et al. (author) Cholesterol lowering and the use of healthcare resources. Results of the Scandinavian Simvastatin Survival Study 1996 In: Circulation. - 0009-7322. ; 93:10, s. 1796-1802 Journal article (peer-reviewed)
2.	Poley, L., et al. (author) The ABC130 barrel module prototyping programme for the ATLAS strip tracker 2020 In: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 15:9 Journal article (peer-reviewed)abstract For the Phase-II Upgrade of the ATLAS Detector [1], its Inner Detector, consisting of silicon pixel, silicon strip and transition radiation sub-detectors, will be replaced with an all new 100% silicon tracker, composed of a pixel tracker at inner radii and a strip tracker at outer radii. The future ATLAS strip tracker will include 11,000 silicon sensor modules in the central region (barrel) and 7,000 modules in the forward region (end-caps), which are foreseen to be constructed over a period of 3.5 years. The construction of each module consists of a series of assembly and quality control steps, which were engineered to be identical for all production sites. In order to develop the tooling and procedures for assembly and testing of these modules, two series of major prototyping programs were conducted: an early program using readout chips designed using a 250 nm fabrication process (ABCN-250) [2, 3] and a subsequent program using a follow-up chip set made using 130 nm processing (ABC130 and HCC130 chips). This second generation of readout chips was used for an extensive prototyping program that produced around 100 barrel-type modules and contributed significantly to the development of the final module layout. This paper gives an overview of the components used in ABC130 barrel modules, their assembly procedure and findings resulting from their tests.
3.	Boddington, C, et al. (author) Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials 2019 In: Lancet (London, England). - 1474-547X. ; 393:10179, s. 1440-1452 Journal article (peer-reviewed)
4.	Bergh, J, et al. (author) Trastuzumab for early-stage, HER2-positive breast cancer: a meta-analysis of 13 864 women in seven randomised trials 2021 In: The Lancet. Oncology. - 1474-5488. ; 22:8, s. 1139-1150 Journal article (peer-reviewed)
5.	Backstrom-Eriksson, L, et al. (author) Anxiety and depression in adults with cystic fibrosis: a comparison between patients and the general population in Sweden and three other European countries 2015 In: BMC pulmonary medicine. - : Springer Science and Business Media LLC. - 1471-2466. ; 15, s. 121- Journal article (peer-reviewed)
6.	Backstrom-Eriksson, L, et al. (author) ANXIETY AND DEPRESSION IN THE SWEDISH ADULT CF POPULATION 2014 In: PEDIATRIC PULMONOLOGY. - 8755-6863. ; 49, s. 436-437 Conference paper (other academic/artistic)
7.	Backström-Eriksson, L, et al. (author) Associations between genetics, medical status, physical exercise and psychological well-being in adults with cystic fibrosis 2016 In: BMJ open respiratory research. - : BMJ. - 2052-4439. ; 3:1, s. e000141- Journal article (peer-reviewed)
8.	Carlsson, Per-Ola, et al. (author) Microdialysis measurements demonstrate a shift to nonoxidative glucosemetabolism in rat pancreatic islets transplanted beneath the renalcapsule. 2002 In: Surgery. ; 132, s. 487- Journal article (peer-reviewed)
9.	Siemens, N, et al. (author) Biofilm in group A streptococcal necrotizing soft tissue infections 2016 In: JCI insight. - : American Society for Clinical Investigation. - 2379-3708. ; 1:10, s. e87882- Journal article (peer-reviewed)
10.	Skrtic, Stanko, 1970, et al. (author) Exploring the insulin secretory properties of the PGD(2)-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients 2018 In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:12 Journal article (peer-reviewed)abstract Aims/Hypothesis GPR44 (DP2, PTGDR2, CRTh2) is the receptor for the pro-inflammatory mediator prosta-glandin D-2 (PGD(2)) and it is enriched in human islets. In rodent islets, PGD(2) is produced in response to glucose, suggesting that the PGD(2)-GPR44/DP2 axis may play a role in human islet function during hyperglycemia. Consequently, the aim of this work was to elucidate the insulinotropic role of GPR44 antagonism in vitro in human beta-cells and in type 2 diabetes (T2DM) patients. We determined the drive on PGD(2) secretion by glucose and IL-1 beta, as well as, the impact on insulin secretion by pharmacological GPR44/DP2 antagonism (AZD1981) in human islets and beta-cells in vitro. To test if metabolic control would be improved by antagonizing a hyperglycemia-driven increased PGD(2) tone, we performed a proof-of-mechanism study in 20 T2DM patients (average 54 years, HbA1c 9.4%, BMI 31.6 kg/m(2)). The randomized, double-blind, placebo-controlled cross-over study consisted of two three-day treatment periods (AZD1981 or placebo) separated by a three-day wash-out period. Mixed meal tolerance test (MMTT) and intravenous graded glucose infusion (GGI) was performed at start and end of each treatment period. Assessment of AZD1981 pharmacokinetics, glucose, insulin, C-peptide, glucagon, GLP-1, and PGD(2) pathway biomarkers were performed. We found (1) that PGD(2) is produced in human islet in response to high glucose or IL-1 beta, but likely by stellate cells rather than endocrine cells; (2) that PGD(2) suppresses both glucose and GLP-1 induced insulin secretion in vitro; and (3) that the GPR44/DP2 antagonist (AZD1981) in human beta-cells normalizes insulin secretion. However, AZD1981 had no impact on neither glucose nor incretin dependent insulin secretion in humans (GGI AUC (C-peptide 1-2h) and MMTT AUC (Glucose 0-4h) LS mean ratios vs placebo of 0.94 (80% CI of 0.90-0.98, p = 0.12) and 0.99 (90% CI of 0.94-1.05, p = 0.45), despite reaching the expected antagonist exposure. Pharmacological inhibition of the PGD(2)-GPR44/DP2 axis has no major impact on the modulation of acute insulin secretion in T2DM patients.

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Type of publication: journal article (48); reports (20); conference paper (15); book chapter (2); doctoral thesis (1); licentiate thesis (1); show more...; show less...

Type of content: peer-reviewed (57); other academic/artistic (30)

Author/Editor: Mathiassen, Svend Er ... (27); Larsson, Johan, 1979 ... (16); Kjellberg, Anders (13); Hang, L. (6); Svanborg, Catharina (5); Godaly, Gabriela (5); show more...; Kwak, Lydia (4); Ellström, Patrik (4); Bergsten, Peter (4); Fischer, H. (3); Stigson, Helena, 197 ... (3); Fischer, Hans (3); Gustafsson, E. (3); Hjelte, L (3); Sorjonen, K (3); Cameron, D. (2); Wang, X. (2); Davidson, N. (2); Taylor, C. (2); Bergh, J (2); Liu, Z. (2); Gnant, M. (2); Whelan, T. (2); Svensson, M. (2); Ryden-Bergsten, T. (2); Anderson, S (2); Martin, M. (2); Hill, C. (2); Wilcken, N (2); Di Leo, A (2); Norton, L (2); Cuzick, J (2); Clarke, M (2); Gray, R (2); MacKinnon, E (2); McGale, P (2); Peto, R (2); Arriagada, R (2); Pritchard, KI (2); Dignam, J (2); Wolmark, N (2); Albain, K (2); Dowsett, M (2); Viale, G (2); Svanborg, C (2); Hedlund, M. (2); Bergsten, Tobias (2); Hedlund, Maria (2); Bergsten, Johannes, ... (2); Bliss, J (2); show less...

University: University of Gävle (47); Uppsala University (21); Karolinska Institutet (20); Lund University (9); Chalmers University of Technology (7); Linnaeus University (6); show more...; University of Gothenburg (3); Halmstad University (3); Stockholm University (3); Royal Institute of Technology (2); RISE (2); Swedish Museum of Natural History (2); Swedish University of Agricultural Sciences (2); VTI - The Swedish National Road and Transport Research Institute (2); Kristianstad University College (1); Umeå University (1); Luleå University of Technology (1); Örebro University (1); Linköping University (1); Jönköping University (1); Karlstad University (1); show less...

Language: English (65); Swedish (22)

Research subject (UKÄ/SCB): Medical and Health Sciences (57); Natural sciences (10); Social Sciences (5); Engineering and Technology (1); Agricultural Sciences (1)

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