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- Andersen, Flemming, et al.
(författare)
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Reduced content of chloroatranol and atranol in oak moss absolute significantly reduces the elicitation potential of this fragrance material
- 2015
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 72:2, s. 75-83
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundOak moss absolute, an extract from the lichen Evernia prunastri, is a valued perfume ingredient but contains extreme allergens. ObjectivesTo compare the elicitation properties of two preparations of oak moss absolute: classic oak moss', the historically used preparation, and new oak moss', with reduced contents of the major allergens atranol and chloroatranol. Patients/materials/methodsThe two preparations were compared in randomized double-blinded repeated open application tests and serial dilution patch tests in 30 oak moss-sensitive volunteers and 30 non-allergic control subjects. ResultsIn both test models, new oak moss elicited significantly less allergic contact dermatitis in oak moss-sensitive subjects than classic oak moss. The control subjects did not react to either of the preparations. ConclusionsNew oak moss is still a fragrance allergen, but elicits less allergic contact dermatitis in previously oak moss-sensitized individuals, suggesting that new oak moss is less allergenic to non-sensitized individuals.
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