| 1. |
- Bijelic, Goran, et al.
(författare)
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Adsorption characteristics of brush polyelectrolytes on silicon oxynitride revealed by dual polarisation interferometry
- 2010
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Ingår i: Journal of Colloid and Interface Science. - : Elsevier BV. - 0021-9797 .- 1095-7103. ; 348, s. 189-197
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Tidskriftsartikel (refereegranskat)abstract
- Adsorption properties of bottle-brush polyelectrolytes have been investigated using dual polarization interferometry (DPI), which provides real time monitoring of adsorbed layer thickness and refractive index. The adsorption on silicon oxynitride was carried out from aqueous solution with no added inorganic salt, and the adsorbed polyelectrolyte layer was subsequently rinsed with NaCl solutions of increasing concentration. The bottle-brush polyelectrolytes investigated in this study have different ratios of permanent cationic charged segments and uncharged PEO side chains. Both the cationic groups and the PEO side chains have affinity for silica-like surfaces, and thus contribute to the adsorption process that becomes rather complex. Adsorption properties in water, responses to changes in ionic strength of the surrounding medium, adsorption kinetics and the layer structure are all strongly dependent on the ratio between backbone charges and side chains. The results are interpreted in terms of competitive adsorption of segments with different chemical nature. The adsorption kinetics is relatively fast, taking only tens to hundreds of seconds when adsorbed from dilute 100 ppm solutions. The DPI technique was found to be suitable for studying such rapid adsorption processes, including determination of the initial adsorption kinetics. We expect that the effects observed in this study are of general importance for synthetic and biological polymers carrying segments of different nature.
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| 2. |
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| 3. |
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| 4. |
- Crema, Andrea, et al.
(författare)
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Helping Hand grasp rehabilitation : Preliminary assessment on chronic stroke patients
- 2017
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Ingår i: 8th International IEEE EMBS Conference on Neural Engineering, NER 2017. - 9781538619162 ; , s. 146-149
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Konferensbidrag (refereegranskat)abstract
- The Helping Hand (HH) system is a novel grasp rehabilitation platform aimed at simplifying the clinical usage of wearable electrode arrays for neuromuscular electrical stimulation (NMES). In a randomized dose-matched, clinical study we evaluate usability and effectiveness of the HH treatment, and of other enriched upper limb rehabilitation treatments, and compare the outcomes. This paper shows the preliminary clinical results of the trial on 5 chronic stroke patients throughout a 9 weeks, 3 hours per week, hand preshaping training.
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| 5. |
- Dujović, Suzana Dedijer, et al.
(författare)
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Novel multi-pad functional electrical stimulation in stroke patients : A single-blind randomized study
- 2017
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Ingår i: NeuroRehabilitation. - 1053-8135. ; 41:4, s. 791-800
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Foot drop is common gait impairment after stroke. Functional electrical stimulation (FES) of the ankle dorsiflexor muscles during the swing phase of gait can help correcting foot drop. OBJECTIVE: To evaluate efficacy of additional novel FES system to conventional therapy in facilitating motor recovery in the lower extremities and improving walking ability after stroke. METHODS: Sixteen stroke patients were randomly allocated to the FES group (FES therapy plus conventional rehabilitation program) (n=8), and control group (conventional rehabilitation program) n=8. FES was delivered for 30min during gait to induce ankle plantar and dorsiflexion. Main outcome measures: Gait speed using 10 Meter Walk Test (10 MWT), Fugl-Meyer Assessment (FMA), Berg Balance Scale (BBS) and modified Barthel Index (MBI). RESULTS: Results showed a significant increase in gait speed in FES group (p<0.001), higher than the minimal detected change. The FES group showed improvement in functional independence in the activities of daily living, motor recovery and gait performance. CONCLUSIONS: The findings suggest that novel FES therapy combined with conventional rehabilitation is more effective on walking speed, mobility of the lower extremity, balance disability and activities of daily living compared to a conventional rehabilitation program only.
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| 6. |
- Hermanowska, Malgorzata, et al.
(författare)
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Charges in phospholipid layers
- 2009
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Ingår i: Biophysical Journal. - : CELL PRESS. - 0006-3495 .- 1542-0086. ; 96:3, s. 18A-18A
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Malešević, Jovana, et al.
(författare)
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A decision support system for electrode shaping in multi-pad FES foot drop correction
- 2017
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Ingår i: Journal of NeuroEngineering and Rehabilitation. - : Springer Science and Business Media LLC. - 1743-0003. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Functional electrical stimulation (FES) can be applied as an assistive and therapeutic aid in the rehabilitation of foot drop. Transcutaneous multi-pad electrodes can increase the selectivity of stimulation; however, shaping the stimulation electrode becomes increasingly complex with an increasing number of possible stimulation sites. We described and tested a novel decision support system (DSS) to facilitate the process of multi-pad stimulation electrode shaping. The DSS is part of a system for drop foot treatment that comprises a custom-designed multi-pad electrode, an electrical stimulator, and an inertial measurement unit. Methods: The system was tested in ten stroke survivors (3-96 months post stroke) with foot drop over 20 daily sessions. The DSS output suggested stimulation pads and parameters based on muscle twitch responses to short stimulus trains. The DSS ranked combinations of pads and current amplitudes based on a novel measurement of the quality of the induced movement and classified them based on the movement direction (dorsiflexion, plantar flexion, eversion and inversion) of the paretic foot. The efficacy of the DSS in providing satisfactory pad-current amplitude choices for shaping the stimulation electrode was evaluated by trained clinicians. The range of paretic foot motion was used as a quality indicator for the chosen patterns. Results: The results suggest that the DSS output was highly effective in creating optimized FES patterns. The position and number of pads included showed pronounced inter-patient and inter-session variability; however, zones for inducing dorsiflexion and plantar flexion within the multi-pad electrode were clearly separated. The range of motion achieved with FES was significantly greater than the corresponding active range of motion (p < 0.05) during the first three weeks of therapy. Conclusions: The proposed DSS in combination with a custom multi-pad electrode design covering the branches of peroneal and tibial nerves proved to be an effective tool for producing both the dorsiflexion and plantar flexion of a paretic foot. The results support the use of multi-pad electrode technology in combination with automatic electrode shaping algorithms for the rehabilitation of foot drop. Trial registration: This study was registered at the Current Controlled Trials website with ClinicalTrials.gov ID NCT02729636 on March 29, 2016.
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| 8. |
- Malešević, Jovana, et al.
(författare)
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Smart protocols for physical therapy of foot drop based on functional electrical stimulation : A case study
- 2021
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Ingår i: Healthcare. - : MDPI AG. - 2227-9032. ; 9:5
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Tidskriftsartikel (refereegranskat)abstract
- Functional electrical stimulation (FES) is used for treating foot drop by delivering electrical pulses to the anterior tibialis muscle during the swing phase of gait. This treatment requires that a patient can walk, which is mostly possible in the later phases of rehabilitation. In the early phase of recovery, the therapy conventionally consists of stretching exercises, and less commonly of FES delivered cyclically. Nevertheless, both approaches minimize patient engagement, which is inconsistent with recent findings that the full rehabilitation potential could be achieved by an active psycho-physical engagement of the patient during physical therapy. Following this notion, we proposed smart protocols whereby the patient sits and ankle movements are FES-induced by self-control. In six smart protocols, movements of the paretic ankle were governed by the non-paretic ankle with different control strategies, while in the seventh voluntary movements of the paretic ankle were used for stimulation triggering. One stroke survivor in the acute phase of recovery participated in the study. During the therapy, the patient’s voluntary ankle range of motion increased and reached the value of normal gait after 15 sessions. Statistical analysis did not reveal the differences between the protocols in FES-induced movements.
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| 9. |
- Popovic, Dejan B., et al.
(författare)
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Lumbar Stimulation Belt for Therapy of Low-Back Pain
- 2009
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Ingår i: Artificial Organs. - : Wiley. - 0160-564X .- 1525-1594. ; 33:1, s. 54-60
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Tidskriftsartikel (refereegranskat)abstract
- We developed the STIMBELT, an electrical stimulation system that comprises a lumbar belt with up to eight pairs of embedded electrodes and an eight-channel electronic stimulator. The STIMBELT is an assistive system for the treatment of low-back pain (LBP). We describe here technical details of the system and summarize the results of its application in individuals with subacute and chronic LBP. The direct goals of the treatment were to relieve pain, reduce muscle spasms, increase strength and range of motion, and educate individuals with LBP in reducing the chances of its reoccurrence. The outcome measures include: a Visual Analogue Scale (VAS), the Oswestry LBP Disability Questionnaire, the Short Form (SF)-12 health survey, and the Manual Muscle Test. The results indicate significant benefits for individuals who use the STIMBELT in addition to the conventional therapy as opposed to only the conventional therapy.
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| 10. |
- Shovsky, Oleksandr, et al.
(författare)
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Adsorption Characteristics of Stoichiometric and Nonstoichiometric Molecular Polyelectrolyte Complexes on Silicon Oxynitride Surfaces
- 2011
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 27:3, s. 1044-1050
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Tidskriftsartikel (refereegranskat)abstract
- Adsorption properties of stoichiometric and nonstoichiometric polyelectrolyte complexes (PECs) have been investigated by means of dual polarization interferometry (DPI) and X-ray photoelectron spectroscopy (XPS). Poly(sodium styrenesulfonate) (NaPSS) of molecular weight 4300 g/mol was used as polyanion, and two bottle-brush copolymers possessing different molar ratios of the cationic segment methacryloxyethyltrimethylammonium chloride (METAC) and the nonionic segment poly(ethylene oxide) methyl ether methacrylate (PEO(45)MEMA) were used as polycations. They are referred to as PEO(45)MEMA:METAC-25 and PEO(45)MEMA:METAC-50, where the last digits denote the mol % of charged main-chain segments. The time evolution of the adsorbed amount, thickness, and refractive index of the PEC layers were determined in aqueous solution using DPI. We demonstrate that cationic, uncharged, and negatively charged complexes adsorb to negatively charged silicon oxynitride and that maximum adsorption is achieved when small amounts of PSS are present in the complexes. The surface composition of the adsorbed PEC layers was estimated from XPS measurements that demonstrated very low content of NaPSS. On the basis of these data, the PEC adsorption mechanism is discussed and the competition between PSS and negative surface sites for association with the cationic polyelectrolyte is identified as a key issue.
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