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- Makitalo, S., et al.
(författare)
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The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer's disease
- 2015
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Ingår i: Aids Research and Therapy. - : Springer Science and Business Media LLC. - 1742-6405. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- It is a challenge to differentiate between HIV-associated neurocognitive disorders (HAND) and other types of neurocognitive disease in the ageing HIV-infected population. Here we describe a 63 year old HIV-infected woman who had a history, neuropsychological test result, and PET examination consistent with characteristic Alzheimer's disease (AD). The cerebrospinal fluid (CSF) biomarker profile was analogous to the profile typically found in AD in HIV-negative patients with increased t-tau and p-tau, a decreased level of A beta 42 and normal levels of CSF neurofilament light protein and sAPP alpha and sAPP beta, distinctly different from findings in HIV-associated dementia (HAD). Assessment of CSF biomarkers may be a valuable tool for clinicians to distinguish between HAD and AD.
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