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Search: WFRF:(Buchalla W)

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  • Cieplik, F, et al. (author)
  • Phenalen-1-One-Mediated Antimicrobial Photodynamic Therapy and Chlorhexidine Applied to a Novel Caries Biofilm Model
  • 2018
  • In: Caries research. - : S. Karger AG. - 1421-976X .- 0008-6568. ; 52:6, s. 447-453
  • Journal article (peer-reviewed)abstract
    • Antimicrobial photodynamic therapy (aPDT) may be useful as a supportive antimicrobial measure for caries-active subjects. In this study, the antimicrobial efficacy of aPDT with a phenalen-1-one photosensitizer was evaluated in a novel in vitro biofilm model comprising <i>Actinomyces naeslundii</i>, <i>Actinomyces odontolyticus</i>, and <i>Streptococcus mutans</i> and was compared to chlorhexidine. The proposed biofilm model allows high-throughput screening for antimicrobial efficacy while exhibiting a differentiated response to different antimicrobial approaches. While chlorhexidine 0.2% showed a reduction of ≈4 log<sub>10</sub> for all species, aPDT led to a more pronounced reduction of <i>S. mutans</i> (2.8 log<sub>10</sub>) than of <i>Actinomyces</i> spp. (1.2 or 1.3 log<sub>10</sub>). A similar effect was also observed in monospecies biofilms. Therefore, aPDT may be more effective against <i>S. mutans</i> than against <i>Actinomyces</i> spp. when in biofilms, and this antimicrobial approach merits further investigations.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Belibasakis, GN (2)
Thurnheer, T (2)
Cieplik, F (2)
Muehler, D (2)
Hiller, KA (2)
Maisch, T (2)
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Buchalla, W (2)
Wimmer, F (1)
Steinwachs, VS (1)
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University
Karolinska Institutet (2)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2018 (2)

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