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- Broussalis, Adriana M., et al.
(författare)
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First cyclotide from Hybanthus (Violaceae)
- 2001
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Ingår i: Phytochemistry. - : Elsevier. - 0031-9422 .- 1873-3700. ; 58:1, s. 47-51
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Tidskriftsartikel (refereegranskat)abstract
- Hypa A, a novel macrocyclic polypeptide containing 30 amino acid residues, has been isolated from the n-butanol extract of the Argentine plant Hybanthus parviflorus. The sequence, cyclo-(SCVYIPCTITALLGCSCKNKVCYNGIPCAE), was determined by automated Edman degradation, quantitative amino acid analysis and nanospray MS/MS2. Three intramolecular disulfide bridges stabilize the cyclic peptide backbone of hypa A. Using these structural features to classify the peptide as a cyclotide, we extended the distribution of that substance class to a new genus, and now propose a uniform nomenclature for cyclotides.
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