| 1. |
- Botvinik-Nezer, Rotem, et al.
(author)
-
Variability in the analysis of a single neuroimaging dataset by many teams
- 2020
-
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 582, s. 84-88
-
Journal article (peer-reviewed)abstract
- Data analysis workflows in many scientific domains have become increasingly complex and flexible. Here we assess the effect of this flexibility on the results of functional magnetic resonance imaging by asking 70 independent teams to analyse the same dataset, testing the same 9 ex-ante hypotheses(1). The flexibility of analytical approaches is exemplified by the fact that no two teams chose identical workflows to analyse the data. This flexibility resulted in sizeable variation in the results of hypothesis tests, even for teams whose statistical maps were highly correlated at intermediate stages of the analysis pipeline. Variation in reported results was related to several aspects of analysis methodology. Notably, a meta-analytical approach that aggregated information across teams yielded a significant consensus in activated regions. Furthermore, prediction markets of researchers in the field revealed an overestimation of the likelihood of significant findings, even by researchers with direct knowledge of the dataset(2-5). Our findings show that analytical flexibility can have substantial effects on scientific conclusions, and identify factors that may be related to variability in the analysis of functional magnetic resonance imaging. The results emphasize the importance of validating and sharing complex analysis workflows, and demonstrate the need for performing and reporting multiple analyses of the same data. Potential approaches that could be used to mitigate issues related to analytical variability are discussed. The results obtained by seventy different teams analysing the same functional magnetic resonance imaging dataset show substantial variation, highlighting the influence of analytical choices and the importance of sharing workflows publicly and performing multiple analyses.
|
|
| 2. |
- Kamata, Yohei, et al.
(author)
-
Hydration and Ordering of Lamellar Block Copolymer Films under Controlled Water Vapor
- 2014
-
In: Macromolecules. - : American Chemical Society (ACS). - 0024-9297 .- 1520-5835. ; 47:24, s. 8682-8690
-
Journal article (peer-reviewed)abstract
- Amphiphilic block copolymers within a range of volume fraction spontaneously form vesicles in aqueous solution, where a water core is enclosed by a polymer bilayer. Thin-film rehydration is a method used to produce vesicles routinely; a thin film is immersed in water, the film swells, and vesicles are formed which bleb off from the film surface. We have studied the early stages of hydration for PEOPBO block copolymer thin films under controlled water vapor conditions to understand this formation mechanism and so enable more efficient ways to encapsulate molecules using this method. Neutron and X-ray measurements show that the initial film exhibits weakly ordered structure with isotropic parallel and vertical orientation; the films initially swell and maintain the same orientation. At a critical point the layer swells rapidly and makes highly ordered lamellae structure at the same time. The lamellae are almost exclusively oriented parallel to the substrate and swell with increasing water absorption.
|
|
| 3. |
- Repapi, Emmanouela, et al.
(author)
-
Genome-wide association study identifies five loci associated with lung function.
- 2010
-
In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:1, s. 36-44
-
Journal article (peer-reviewed)abstract
- Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n < or = 32,184 additional individuals) and in silico summary association data from the CHARGE Consortium (n = 21,209) and the Health 2000 survey (n < or = 883). We confirmed the reported locus at 4q31 and identified associations with FEV(1) or FEV(1)/FVC and common variants at five additional loci: 2q35 in TNS1 (P = 1.11 x 10(-12)), 4q24 in GSTCD (2.18 x 10(-23)), 5q33 in HTR4 (P = 4.29 x 10(-9)), 6p21 in AGER (P = 3.07 x 10(-15)) and 15q23 in THSD4 (P = 7.24 x 10(-15)). mRNA analyses showed expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in human lung tissue. These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.
|
|
| 4. |
- Willer, Cristen J., et al.
(author)
-
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
- 2009
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:1, s. 25-34
-
Journal article (peer-reviewed)abstract
- Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
|
|
| 5. |
- Dennison, Andrew J. C., et al.
(author)
-
Graphite intercalation compound (GIC) crystal monochromators for cold neutron instruments : Characterization of KC24 by time-of-flight neutron diffraction
- 2021
-
In: Review of Scientific Instruments. - : American Institute of Physics (AIP). - 0034-6748 .- 1089-7623. ; 92:2
-
Journal article (peer-reviewed)abstract
- Graphite intercalation compounds (GICs) are a group of layered materials that are suitable as monochromators for cold neutrons. KC24 is a particularly interesting compound in this regard as it features a large c-axis lattice spacing of 8.74 angstrom, high reflectivity, and the possibility to produce large crystals with mosaicity that matches the beam divergence of cold neutron guides. GICs can be synthesized with different levels of intercalation, known as the stage of the compounds. Each stage displays a specific d-spacing. Impure GIC-monochromators containing multiple stages produce mixing of neutron wavelengths, which complicates data analysis on neutron reflectometers. We discuss the implications of GIC crystal purity and stage contamination for neutron reflectometry and show how GIC crystals can be characterized by time-of-flight neutron diffraction providing an efficient and quantifiable measure of the reflected wavelength spectrum. This allows taking into account multiple wavelength contaminations and ascertains the robustness of reflectometry measurements.
|
|
| 6. |
|
|
| 7. |
- Dennison, James, et al.
(author)
-
The centre no longer holds : the Lega, Matteo Salvini and the remaking of Italian immigration politics
- 2022
-
In: Journal of ethnic and migration studies. - 1369-183X .- 1469-9451. ; 48:2, s. 441-460
-
Journal article (peer-reviewed)abstract
- This article asks how policy responses to migration in Italy have been shaped both by issue salience and by changing configurations on the centre right of Italian party politics both prior to and following the 2015 'migration crisis'. We show that, first, the increased politicisation of 'irregular' arrivals into Italy after 2015 changed migration from a relatively 'quiet' policy issue to one of 'loud' politics meaning that it was highly salient to the public. This salience significantly advantaged the Lega, who by this point had already transformed into an archetypal, European populist radical right party, but could now campaign successfully nationally and dominate the nominal 'centre-right' coalition. Second, the imposition when in government between June 2018 and September 2019 by the Lega of policies for migrants and asylum-seekers that focussed solely on prevention and removal and ended what remained of prior policy drift. We show that both trends conform to theoretical expectations regarding the relative power of interest groups and public opinion over public policy that are contingent on public issue salience, which we show to be the most plausible determinant of variation in migration policy, rather than public attitudes or party positions, during the period.
|
|
| 8. |
- Dennison, James, et al.
(author)
-
Thinking Globally about Attitudes to Immigration : Concerns about Social Conflict, Economic Competition and Cultural Threat
- 2021
-
In: Political quarterly (London. 1930. Print). - : Wiley. - 0032-3179 .- 1467-923X. ; 92:3, s. 541-551
-
Journal article (peer-reviewed)abstract
- This article looks globally at the motivations behind attitudes to immigration. Such motivations have been typically conceptualised by academics either in terms of the ‘economic competition’ or ‘cultural threat’ that immigrants are perceived to pose to the individual or their ‘in-group’. We propose and test a third possibility: that support for or opposition to immigration is determined by one's perceptions of immigration's effects on social conflict. Using the 2017–2020 World Values Survey (WVS) for forty-nine countries, we show that: in most countries, globally, citizens are more likely to agree than disagree that immigration leads to social conflict; levels of concern about the effects of immigration on social conflict are higher than those regarding unemployment or culture in sixteen—disproportionately economically developed—countries; concern about social conflict is conceptually and distributionally distinct; belief that immigration leads to social conflict predicts immigration policy preferences; but, uniquely, is positively predicted by higher education. Our findings highlight the importance of institutional conflict resolution capacity, including those related to integration, for the politics of migration.
|
|
| 9. |
- Devishvili, A., et al.
(author)
-
SuperADAM : Upgraded polarized neutron reflectometer at the Institut Laue-Langevin
- 2013
-
In: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 84:2, s. 025112-
-
Journal article (peer-reviewed)abstract
- A new neutron reflectometer SuperADAM has recently been built and commissioned at the Institut Laue-Langevin, Grenoble, France. It replaces the previous neutron reflectometer ADAM. The new instrument uses a solid state polarizer/wavelength filter providing a highly polarized (up to 98.6%) monochromatic neutron flux of 8 x 10(4) n cm(-2) s(-1) with monochromatization Delta lambda/lambda = 0.7% and angular divergence Delta alpha = 0.2 mrad. The instrument includes both single and position sensitive detectors. The position sensitive detector allows simultaneous measurement of specular reflection and off-specular scattering. Polarization analysis for both specular reflection and off-specular scattering is achieved using either mirror analyzers or a He-3 spin filter cell. High efficiency detectors, low background, and high flux provides a dynamic range of up to seven decades in reflectivity. Detailed specifications and the instrument capabilities are illustrated with examples of recently collected data in the fields of thin film magnetism and thin polymer films.
|
|
| 10. |
- Estrada, Karol, et al.
(author)
-
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
- 2012
-
In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:5, s. 491-501
-
Journal article (peer-reviewed)abstract
- Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility.
|
|
