| 1. |
- Bloomfield, Madeleine, et al.
(författare)
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European Autism GEnomics Registry (EAGER): protocol for a multicentre cohort study and registry
- 2024
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Ingår i: BMJ OPEN. - 2044-6055. ; 14:6
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Autism is a common neurodevelopmental condition with a complex genetic aetiology that includes contributions from monogenic and polygenic factors. Many autistic people have unmet healthcare needs that could be served by genomics-informed research and clinical trials. The primary aim of the European Autism GEnomics Registry (EAGER) is to establish a registry of participants with a diagnosis of autism or an associated rare genetic condition who have undergone whole-genome sequencing. The registry can facilitate recruitment for future clinical trials and research studies, based on genetic, clinical and phenotypic profiles, as well as participant preferences. The secondary aim of EAGER is to investigate the association between mental and physical health characteristics and participants' genetic profiles.Methods and analysis EAGER is a European multisite cohort study and registry and is part of the AIMS-2-TRIALS consortium. EAGER was developed with input from the AIMS-2-TRIALS Autism Representatives and representatives from the rare genetic conditions community. 1500 participants with a diagnosis of autism or an associated rare genetic condition will be recruited at 13 sites across 8 countries. Participants will be given a blood or saliva sample for whole-genome sequencing and answer a series of online questionnaires. Participants may also consent to the study to access pre-existing clinical data. Participants will be added to the EAGER registry and data will be shared externally through established AIMS-2-TRIALS mechanisms.Ethics and dissemination To date, EAGER has received full ethical approval for 11 out of the 13 sites in the UK (REC 23/SC/0022), Germany (S-375/2023), Portugal (CE-085/2023), Spain (HCB/2023/0038, PIC-164-22), Sweden (Dnr 2023-06737-01), Ireland (230907) and Italy (CET_62/2023, CEL-IRCCS OASI/24-01-2024/EM01, EM 2024-13/1032 EAGER). Findings will be disseminated via scientific publications and conferences but also beyond to participants and the wider community (eg, the AIMS-2-TRIALS website, stakeholder meetings, newsletters).
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| 2. |
- Daar, Abdallah S, et al.
(författare)
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Declaration on mental health in Africa : moving to implementation
- 2014
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Ingår i: Global Health Action. - : Informa UK Limited. - 1654-9716 .- 1654-9880. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Urgent action is needed to address mental health issues globally. In Africa, where mental health disorders account for a huge burden of disease and disability, and where in general less than 1% of the already small health budgets are spent on these disorders, the need for action is acute and urgent. Members of the World Health Organization, including African countries, have adopted a Comprehensive Mental Health Action Plan. Africa now has an historic opportunity to improve the mental health and wellbeing of its citizens, beginning with provision of basic mental health services and development of national mental health strategic plans (roadmaps). There is need to integrate mental health into primary health care and address stigma and violations of human rights. We advocate for inclusion of mental health into the post-2015 Sustainable Development Goals, and for the convening of a special UN General Assembly High Level Meeting on Mental Health within three years.
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| 3. |
- Ekström, Fredrik, et al.
(författare)
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Crystallization and X-ray analysis of a bacterial non-haem iron-containing phenylalanine hydroxylase from the Gram-negative opportunistic pathogen Pseudomonas aeruginosa.
- 2003
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Ingår i: Acta Crystallogr D Biol Crystallogr. - 0907-4449. ; 59:Pt 7, s. 1310-2
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Tidskriftsartikel (refereegranskat)abstract
- Monooxygenases are frequently involved in the pathways that mediate the pivotal role of microorganisms in recycling carbon from the environment. A structural study of a monooxygenase from Pseudomonas aeruginosa that was identified as a phenylalanine hydroxylase has been initiated. The single-domain monomeric protein harbours a non-haem iron at the active site. The sequence identity to the catalytic domains of tyrosine and tryptophan hydroxylases suggests that the enzyme is not restricted to the substrate phenylalanine alone. Here, the cloning, purification and crystallization of native and SeMet-labelled P. aeruginosa phenylalanine hydroxylase are reported. Crystals grew in space group P6(1), with unit-cell parameters a = b = 210.5, c = 100.7 A, and diffracted to a d spacing of 2.0 A. Crystals of SeMet-labelled protein were used to collect a three-wavelength multiple anomalous dispersion (MAD) data set around the Se K edge.
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| 4. |
- Naithani, Sushma, et al.
(författare)
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Govindjee’s 90th birthday – Congratulations from friends and colleagues
- 2022
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Ingår i: Current Plant Biology. - : Elsevier. - 2214-6628. ; 32
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Tidskriftsartikel (refereegranskat)abstract
- On the occasion of the 90th birthday of Govindjee, Professor Emeritus of Plant Biology, Biochemistry, and Biophysics, the University of Illinois at Urbana-Champaign (UIUC), over 100 celebrants have sent felicitations and messages to thank him for mentoring, nurturing, and building the community of photosynthesis researchers belonging to four generations; and in making the scientific knowledge accessible to students and young researchers via his monumental writings and editorial contributions. Govindjee joined UIUC in September of 1956 to study as a graduate student in the laboratory of Robert Emerson. In 1961, he joined UIUC as an Assistant Professor and retired as a full professor in 1999. He is well-known for pioneering work in oxygenic photosynthesis, leading to the current Z-scheme, and for his breakthrough advances concerning light harvesting, primary charge separation, the role of bicarbonate on the two-electron gate of photosystem II, water oxidation, nonphotochemical quenching, and the use of biophysical techniques, such as prompt fluorescence, delayed fluorescence, thermoluminescence, and nuclear magnetic resonance. Today, despite his retirement, Govindjee continues to explore several important questions in the field of photosynthesis and documents the history of science. This tribute, in turn, attempts to capture scientific collaborations, as well as scholarly and personal contributions made by Govindjee to the lives of hundreds of scholars and students worldwide.
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| 5. |
- Ramprakash, Balasubramani, et al.
(författare)
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Current strategies and future perspectives in biological hydrogen production : A review
- 2022
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Ingår i: Renewable & sustainable energy reviews. - : Elsevier. - 1364-0321 .- 1879-0690. ; 168
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Forskningsöversikt (refereegranskat)abstract
- Biohydrogen is a green and eco-friendly energy carrier with the potential to reduce our dependency on fossil fuels. Renewable biohydrogen production from waste biomass sources is potentially cheap; however, large-scale commercial production has not yet been achieved. Problems that need to be tackled include identifying industrially competent microorganisms, and appropriate bioreactor designs enabling novel hybrid methods such as integration of dark fermentation with electro-fermentation and utilization of microbial organisms doped with semiconducting nanomaterials for enhanced production. This review focuses on the production of hydrogen by biological methods, highlighting various fermentation processes, the role of enzymes, and different pretreatment methods. The waste materials used are briefly summarized, and current strategies in biological hydrogen production, including biomimetic and synthetic biology approaches, are assessed for their economic feasibility and their potential to contribute to net zero carbon emission. The lignocellulosic waste and the dynamic membrane bioreactor are the best suitable biomass and bioreactor, respectively for biohydrogen production. The integrated method of dark fermentation and electro-fermentation yields 41% higher hydrogen compared with dark fermentation alone. Finally, this review points out that significant efforts focusing on the development of hybrid fermentation technologies along with the development of novel engineered strains are needed for the commercial-scale production of biohydrogen in the future.
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| 6. |
- Stirbet, Alexandrina, et al.
(författare)
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Celebrating the contributions of Govindjee after his retirement : 1999-2020
- 2020
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Ingår i: New Zealand Journal of Botany. - : Taylor & Francis. - 0028-825X .- 1175-8643. ; 58:4, s. 422-460
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Forskningsöversikt (refereegranskat)abstract
- Govindjee, Professor Emeritus of Biochemistry, Biophysics and Plant Biology at the University of Illinois at Urbana-Champaign since 1999, is renowned for his pioneering work in the light reactions of photosynthesis and important accomplishments as educator, editor, historian and advocate of photosynthesis. In his honour, we review his contributions over the last twenty years, which were often achieved in collaboration with scientists working in laboratories around the world. We start with a short presentation about Govindjee’s career and continue with a section highlighting his passion and dedication to teach the younger generations of students and researchers about photosynthesis. His research work is grouped under different areas, including primary photochemistry; the relationship of chlorophyll a fluorescence to photosynthesis; short time-scale regulation processes of photosynthesis; studies toward improving photosynthesis and biomass yields; and, mathematical modelling of photosynthesis and artificial photosynthesis. He is best known for the discovery of the key role of bicarbonate on the electron acceptor side of Photosystem II. We also present his active involvement in the recognition of scientists at conferences and beyond, as well as of those who are no longer with us. He is committed to keeping alive the pioneers and discoverers in the field of photosynthesis in the collective memory of those in the field.
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| 7. |
- Stirbet, Alexandrina, et al.
(författare)
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Govindjee’s 90th birthday: a life dedicated to photosynthesis
- 2022
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Ingår i: Plant Physiology Reports. - : Springer Nature. - 2662-253X .- 2662-2548. ; 27:4, s. 543-557
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Tidskriftsartikel (refereegranskat)abstract
- We celebrate Govindjee, Professor Emeritus of Plant Biology, Biochemistry, and Biophysics, University of Illinois at Urbana-Champaign, on the occasion of his 90th birthday. He is renowned for his pioneering work in the discovery of the two-light reactions and two photosystems, PSI and PSII, leading to the Z-scheme of the electron transport chain; and for breakthrough advances in oxygenic photosynthesis. Govindjee’s publications have been cited over 26,000 times. He is an elected Fellow of the American Association of the Advancement of Science, USA; National Academy of Agriculture Science, India; and National Academy of Sciences, India; and beyond that, he has received many awards from scientific societies, most recently, the ISPR Lifetime Achievement Award, August 2022. As even today, Govindjee continues to actively contribute to the field, we highlight the major events in his colorful personal and rigorous scientific life with emphasis on the work done after his retirement, and as well, his prodigious accomplishments as teacher, editor, and science historian.
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