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- Arroyo-Torres, B., et al.
(författare)
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VLTI/AMBER Studies of the Atmospheric Structure and Fundamental Parameters of Red Giant and Supergiant Stars
- 2015
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Ingår i: WHY GALAXIES CARE ABOUT AGB STARS III. - : ASTRONOMICAL SOC PACIFIC. - 9781583818794 ; , s. 91-96
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- We present recent near-IR interferometric studies of red giant and super giant stars, which are aimed at obtaining information on the structure of the atmospheric layers and constraining the fundamental parameters of these objects. The observed visibilities of six red supergiants (RSGs), and also of one of the five red giants observed, indicate large extensions of the molecular layers, as previously observed for Mira stars. These extensions are not predicted by hydrostatic PHOENIX model atmospheres, hydrodynamical (RED) simulations of stellar convection, or self-excited pulsation models. All these models based on parameters of RSGs lead to atmospheric structures that are too compact compared to our observations. We discuss how alternative processes might explain the atmospheric extensions for these objects. As the continuum appears to be largely free of contamination by molecular layers, we can estimate reliable Rosseland angular radii for our stars. Together with distances and bolometric fluxes, we estimate the effective temperatures and luminosities of our targets, locate them in the HR diagram, and compare their positions to recent evolutionary tracks.
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| 3. |
- Moreno-Càceres, J, et al.
(författare)
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Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17
- 2014
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Ingår i: Cell Death and Disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Transforming growth factor-beta (TGF-β) plays a dual role in hepatocytes, inducing both pro- and anti-apoptotic responses, whose balance decides cell fate. Survival signals are mediated by the epidermal growth factor receptor (EGFR) pathway, which is activated by TGF-β in these cells. Caveolin-1 (Cav1) is a structural protein of caveolae linked to TGF-β receptors trafficking and signaling. Previous results have indicated that in hepatocytes, Cav1 is required for TGF-β-induced anti-apoptotic signals, but the molecular mechanism is not fully understood yet. In this work, we show that immortalized Cav1(-/-) hepatocytes were more sensitive to the pro-apoptotic effects induced by TGF-β, showing a higher activation of caspase-3, higher decrease in cell viability and prolonged increase through time of intracellular reactive oxygen species (ROS). These results were coincident with attenuation of TGF-β-induced survival signals in Cav1(-/-) hepatocytes, such as AKT and ERK1/2 phosphorylation and NFκ-B activation. Transactivation of the EGFR pathway by TGF-β was impaired in Cav1(-/-) hepatocytes, which correlated with lack of activation of TACE/ADAM17, the metalloprotease responsible for the shedding of EGFR ligands. Reconstitution of Cav1 in Cav1(-/-) hepatocytes rescued wild-type phenotype features, both in terms of EGFR transactivation and TACE/ADAM17 activation. TACE/ADAM17 was localized in detergent-resistant membrane (DRM) fractions in Cav1(+/+) cells, which was not the case in Cav1(-/-) cells. Disorganization of lipid rafts after treatment with cholesterol-binding agents caused loss of TACE/ADAM17 activation after TGF-β treatment. In conclusion, in hepatocytes, Cav1 is required for TGF-β-mediated activation of the metalloprotease TACE/ADAM17 that is responsible for shedding of EGFR ligands and activation of the EGFR pathway, which counteracts the TGF-β pro-apoptotic effects. Therefore, Cav1 contributes to the pro-tumorigenic effects of TGF-β in liver cancer cells.
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