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1.	Hurrell, T, et al. (author) Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis 2020 In: Cells. - : MDPI AG. - 2073-4409. ; 9:4 Journal article (peer-reviewed)abstract Non-alcoholic fatty liver disease affects approximately one billion adults worldwide. Non-alcoholic steatohepatitis (NASH) is a progressive disease and underlies the advancement to liver fibrosis, cirrhosis, and hepatocellular carcinoma, for which there are no FDA-approved drug therapies. We developed a hetero-cellular spheroid system comprised of primary human hepatocytes (PHH) co-cultured with crude fractions of primary human liver non-parenchymal cells (NPC) from several matched or non-matched donors, to identify phenotypes with utility in investigating NASH pathogenesis and drug screening. Co-culture spheroids displayed stable expression of hepatocyte markers (albumin, CYP3A4) with the integration of stellate (vimentin, PDGFRβ), endothelial (vWF, PECAM1), and CD68-positive cells. Several co-culture spheroids developed a fibrotic phenotype either spontaneously, primarily observed in PNPLA3 mutant donors, or after challenge with free fatty acids (FFA), as determined by COL1A1 and αSMA expression. This phenotype, as well as TGFβ1 expression, was attenuated with an ALK5 inhibitor. Furthermore, CYP2E1, which has a strong pro-oxidant effect, was induced by NPCs and FFA. This system was used to evaluate the effects of anti-NASH drug candidates, which inhibited fibrillary deposition following 7 days of exposure. In conclusion, we suggest that this system is suitable for the evaluation of NASH pathogenesis and screening of anti-NASH drug candidates.
2.	Barreby, E, et al. (author) Human resident liver macrophages protect against metabolic stress in obesity 2022 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 77, s. S756-S757 Conference paper (other academic/artistic)
3.	Barreby, E, et al. (author) Human resident liver myeloid cells protect against metabolic stress in obesity 2023 In: Nature metabolism. - 2522-5812. ; 5:7, s. 1188- Journal article (peer-reviewed)
4.	Barreby, E, et al. (author) Human resident liver myeloid cells protect against metabolic stress in obesity 2023 In: Nature metabolism. - 2522-5812. Journal article (peer-reviewed)
5.	Potier, JB, et al. (author) Skeletal muscle derived myokine affects insulin sensitivity and lipogenesis in a human hepatocyte spheroid model 2022 In: DIABETOLOGIA. - 0012-186X. ; 77, s. S667-S667 Conference paper (other academic/artistic)
6.	Fardellas, A, et al. (author) Dissecting A-to-I RNA editome of liver macrophages in non-alcoholic fatty liver disease 2022 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 77, s. S755-S756 Conference paper (other academic/artistic)

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Result 1-6 of 6

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Type of publication: conference paper (3); journal article (3)

Type of content: other academic/artistic (3); peer-reviewed (3)

Author/Editor: Fardellas, A (6); Aouadi, M (5); Chen, P (4); Morgantini, C (4); Nock, S (4); Nowak, G. (3); show more...; Johansson, H (3); Ellis, E (3); Barreby, E (3); Azzimato, V (3); Levi, L (3); Shen, JX (3); Strunz, B (3); Naudet, L (3); Lauschke, VM (2); Naslund, E (2); Coquet, JM (2); Vankova, A (2); Sonnerborg, I (2); Urgard, E (2); Pallett, LJ (2); Maini, MK (2); Rosshart, SP (2); Hu, Y. (1); JOHANSSON, I (1); Ingelman-Sundberg, M (1); Ma, J (1); Stål, P (1); Stal, P (1); Bouzakri, K (1); Bjorkstrom, NK (1); Nordling, A (1); Sulen, A (1); Lauschke, V (1); Näslund, E. (1); Bjorkstrom, N (1); Ma, JJ (1); Hu, YZ (1); Staal, P (1); Sönnerborg, I (1); Björkström, NK (1); Baze, A (1); Parmentier, C (1); Hendriks, DFG (1); Hurrell, T (1); Richert, L (1); Kastrinou-Lampou, V (1); Potier, JB (1); Dumond, A (1); Pinget, M (1); show less...

University: Karolinska Institutet (6)

Language: English (6)

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