| 1. |
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| 2. |
- Abrahamsson, Lena, et al.
(author)
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Projekt: Hästkrafter för entreprenörskap
- 2010
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Other publication (pop. science, debate, etc.)abstract
- En studie av företagande, ledarskap och genus i hästbranschen. Projektet pågick 2009-2011 med finansiering från Stiftelsen Lantbruksforskning (2,5 milj kr). I projektet medverkade Lena Abrahamsson, Mats Westerberg och doktorand Lena Forsberg.
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| 3. |
- Forsberg, Lena, et al.
(author)
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Gender and entrepreneurship in the horse-related industry
- 2013
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In: Journal of Business Diversity. - 2158-3889. ; 12:2, s. 75-93
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Journal article (peer-reviewed)abstract
- In this paper, we examine the horse-related industry in terms of entrepreneurship and gender. Based on reports of the industry, a mapping of the entire sector (N= 7504) and a questionnaire (N=520) we find that the industry is portrayed as female gendered, but dominated by men. However, we also find evidence that the industry is changing gender, as women dominate among younger entrepreneurs. The strongest motives for the horse-related entrepreneurs (regardless of gender) are realizing a dream and being able to combine interest with work. We also found that entrepreneurs in this industry mainly network inside the industry.
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| 4. |
- Forsberg, Lena, et al.
(author)
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Gender and entrepreneurship in the horse-related industry
- 2011
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Conference paper (peer-reviewed)abstract
- In this paper, we examine the horse-related industry in terms of entrepreneurship and gender. Based on reports of the industry, a mapping of the entire sector (N= 7504) and a questionnaire (N=520) we find that the industry is portrayed as female gendered, but dominated by men. However, we also find evidence that the industry is changing gender, as women dominate among younger entrepreneurs. The strongest motives for the horse-related entrepreneurs (regardless of gender) are realizing a dream and being able to combine interest with work. We also found that entrepreneurs in this industry mainly network inside the industry.
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| 5. |
- Forsberg, Maud, et al.
(author)
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Undersulfation of Heparan Sulfate Restricts Differentiation Potential of Mouse Embryonic Stem Cells
- 2012
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In: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 287:14, s. 10853-10862
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Journal article (peer-reviewed)abstract
- Heparan sulfate proteoglycans, present on cell surfaces and in the extracellular matrix, interact with growth factors and morphogens to influence growth and differentiation of cells. The sulfation pattern of the heparan sulfate chains formed during biosynthesis in the Golgi compartment will determine the interaction potential of the proteoglycan. The glucosaminyl N-deacetylase/N-sulfotransferase (NDST) enzymes have a key role during biosynthesis, greatly influencing total sulfation of the heparan sulfate chains. The differentiation potential of mouse embryonic stem cells lacking both NDST1 and NDST2 was studied using in vitro differentiation protocols, expression of differentiation markers, and assessment of the ability of the cells to respond to growth factors. The results show that NDST1 and NDST2 are dispensable for mesodermal differentiation into osteoblasts but necessary for induction of adipocytes and neural cells. Gene expression analysis suggested a differentiation block at the primitive ectoderm stage. Also, GATA4, a primitive endoderm marker, was expressed by these cells. The addition of FGF4 or FGF2 together with heparin rescued the differentiation potential to neural progenitors and further to mature neurons and glia. Our results suggest that the embryonic stem cells lacking both NDST1 and NDST2, expressing a very low sulfated heparan sulfate, can take the initial step toward differentiation into all three germ layers. Except for their potential for mesodermal differentiation into osteoblasts, the cells are then arrested in a primitive ectoderm and/or endoderm stage.
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| 7. |
- Xiong, Anqi, 1986-, et al.
(author)
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Heparanase confers a growth advantage to differentiating murine embryonic stem cells, and enhances oligodendrocyte formation.
- 2017
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In: Matrix Biology. - : Elsevier BV. - 0945-053X .- 1569-1802. ; 62, s. 92-104
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Journal article (peer-reviewed)abstract
- Heparan sulfate proteoglycans (HSPGs), ubiquitous components of mammalian cells, play important roles in development and homeostasis. These molecules are located primarily on the cell surface and in the pericellular matrix, where they interact with a multitude of macromolecules, including many growth factors. Manipulation of the enzymes involved in biosynthesis and modification of HSPG structures alters the properties of stem cells. Here, we focus on the involvement of heparanase (HPSE), the sole endo-glucuronidase capable of cleaving of HS, in differentiation of embryonic stem cells into the cells of the neural lineage. Embryonic stem (ES) cells overexpressing HPSE (Hpse-Tg) proliferated more rapidly than WT ES cells in culture and formed larger teratomas in vivo. In addition, differentiating Hpse-Tg ES cells also had a higher growth rate, and overexpression of HPSE in NSPCs enhanced Erk and Akt phosphorylation. Employing a two-step, monolayer differentiation, we observed an increase in HPSE as wild-type (WT) ES cells differentiated into neural stem and progenitor cells followed by down-regulation of HPSE as these NSPCs differentiated into mature cells of the neural lineage. Furthermore, NSPCs overexpressing HPSE gave rise to more oligodendrocytes than WT cultures, with a concomitant reduction in the number of neurons. Our present findings emphasize the importance of HS, in neural differentiation and suggest that by regulating the availability of growth factors and, or other macromolecules, HPSE promotes differentiation into oligodendrocytes.
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