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Sökning: WFRF:(Gammelgaard B)

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1.
  • Breuer, O, et al. (författare)
  • Intravenous Infusion of High Dose Selenite in End-Stage Cancer Patients: Analysis of Systemic Exposure to Selenite and Seleno-Metabolites
  • 2023
  • Ingår i: Biomedicines. - : MDPI AG. - 2227-9059. ; 11:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Cancer is one of the main causes of human death globally and novel chemotherapeutics are desperately required. As a simple selenium oxide, selenite is a very promising chemotherapeutic because of pronounced its dose-dependent tumor-specific cytotoxicity. We previously published a first-in-man systematic phase I clinical trial in patients with cancer (from IV to end-stage) (the SECAR trial) showing that selenite is safe and tolerable with an unexpectable high maximum tolerated dose (MTD) and short half-life. In the present study, we analyzed the selenium species in plasma samples, from the patients participating in the SECAR trial and from various time points and dose cohorts using LC-ICP-MS. In conclusion, selenite, selenosugars, and 1–2 unidentified peaks that did not correspond to any standard, herein denoted ui-selenium, were detected in the plasma. However, trimethylated selenium (trimethylselenonoium) was not detected. The unidentified ui-selenium was eluting close to the selenium-containing amino acids (selenomethionine and selenocysteine) but was not part of a protein fraction. Our data demonstrate that the major metabolite detected was selenosugar. Furthermore, the identification of selenite even long after the administration is remarkable and unexpected. The kinetic analysis did not support that dosing per the body surface area would reduce interindividual variability of the systemic exposure in terms of trough concentrations.
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4.
  • Juhola, Sirkku, et al. (författare)
  • Adaptation decision-making in the Nordic countries: assessing the potential for joint action
  • 2014
  • Ingår i: Environment Systems and Decisions. - : Springer Science and Business Media LLC. - 2194-5403 .- 2194-5411. ; 34:4, s. 600-611
  • Tidskriftsartikel (refereegranskat)abstract
    • In a global context, the outlook for the Nordic region is relatively favourable, given its relatively stronger resiliency to climate change impacts in comparison to many other geo-political regions of the world. Overall, the projected climatic changes include increases in mean temperatures and in precipitation, although regional variations can be significant. The countries’ robust institutions and economies give them a strong capacity to adapt to these changes. Still, the need for adaptation to the changing climate has been and still is substantial, and in most of the region, there has been progress on the issue. This paper explores the potential for Nordic cooperation on adaptation; specifically, for the development of a regional adaptation strategy. In particular, it addresses two questions (1) What is the current state of adaptation in the Nordic countries? and (2) What are the potential benefits and weaknesses of a Nordic strategy for adaptation? In order to answer these two questions, this paper examines reviews the current national adaptation policies of each Nordic country and discusses the challenges facing a Nordic strategy and finally assesses the potential for common Nordic adaptation policy and further cooperation.
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  • Resultat 1-4 av 4

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