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- Prowle, John R., et al.
(författare)
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Postoperative acute kidney injury in adult non-cardiac surgery : joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative
- 2021
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Ingår i: Nature Reviews Nephrology. - : Springer Nature. - 1759-5061 .- 1759-507X. ; 17:9, s. 605-618
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Forskningsöversikt (refereegranskat)abstract
- The development of acute kidney injury (AKI) after major non-cardiac surgery is associated with substantial long-term morbidity and mortality. This joint Consensus Statement from the Acute Disease Quality Initiative and the PeriOperative Quality Initiative provides recommendations for the definition, prevention and management of postoperative AKI. Postoperative acute kidney injury (PO-AKI) is a common complication of major surgery that is strongly associated with short-term surgical complications and long-term adverse outcomes, including increased risk of chronic kidney disease, cardiovascular events and death. Risk factors for PO-AKI include older age and comorbid diseases such as chronic kidney disease and diabetes mellitus. PO-AKI is best defined as AKI occurring within 7 days of an operative intervention using the Kidney Disease Improving Global Outcomes (KDIGO) definition of AKI; however, additional prognostic information may be gained from detailed clinical assessment and other diagnostic investigations in the form of a focused kidney health assessment (KHA). Prevention of PO-AKI is largely based on identification of high baseline risk, monitoring and reduction of nephrotoxic insults, whereas treatment involves the application of a bundle of interventions to avoid secondary kidney injury and mitigate the severity of AKI. As PO-AKI is strongly associated with long-term adverse outcomes, some form of follow-up KHA is essential; however, the form and location of this will be dictated by the nature and severity of the AKI. In this Consensus Statement, we provide graded recommendations for AKI after non-cardiac surgery and highlight priorities for future research.
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- Fraser, AG, et al.
(författare)
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Feasibility and reproducibility of off-line tissue Doppler measurement of regional myocardial function during dobutamine stress echocardiography
- 2003
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Ingår i: European Journal of Echocardiography. - 1525-2167 .- 1532-2114. ; 4:1, s. 43-53
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Tidskriftsartikel (refereegranskat)abstract
- Aims: Off-line post-processing of colour tissue Doppler from digital loops may allow objective quantification of dobutamine stress echocardiography. We assessed the reproducibility of off-line measurements of regional myocardial velocities. Methods and Results: Nine observers analysed 10 studies, each making 2400 observations. Coefficients of variation in basal segments from apical windows, at rest and maximal stress, were 9-14% and 11-18% for peak systolic velocity, 16-18% and 17-19% for time-to-peak systolic velocity, 9-17% and 18-24% for systolic velocity time integral, and 18-23% and 21-27% for systolic acceleration. Coefficients of variation for diastolic velocities in basal segments at rest were 11-40%. Coefficients of variation for peak systolic velocity were 10-24% at rest and 14-28% at peak in mid segments, and 19-53% and 29-69% in apical segments. From parasternal windows coefficients of variation for peak systolic velocity were 14-16% in basal posterior, and 19-29% in mid-anterior segments. High variability makes measurement unreliable in apical and basal anterior septal segments. The feasibility of obtaining traces was tested in 92 subjects, and >90% in all basal and mid segments apart from the anterior septum. Conclusion: Quantification of myocardial functional reserve by off-line analysis of colour tissue Doppler acquired during dobutamine stress is feasible and reproducible in 11 segments of the left ventricle. The most reliable measurements are systolic velocities of longitudinal motion in basal segments.
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- Ibrahim, Najmus S., et al.
(författare)
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Next-generation for earth monitoring and observation - aerosol monitor
- 2016
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Ingår i: Optical payloads for space missions. - Chichester, UK : John Wiley & Sons. - 9781118945179 - 9781118945148 ; , s. 881-893
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Bokkapitel (refereegranskat)abstract
- The Nanosatellite for Earth Monitoring and Observation Aerosol Monitor (NEMO-AM) is a high performance spacecraft in the final stages of development at the Space Flight Laboratory (SFL). The mission is funded by the Indian Space Research Organization (ISRO) with the purpose of detecting atmospheric aerosols in multiple bands over particular geographical areas with sub-degree accuracy. The satellite design leverages the lessons learned on previous SFL missions and, in part, is developed around the Generic Nanosatellite Bus concept, where a multipurpose and adaptable satellite bus is designed to work with a wide range of payloads with little or no modification. Consequently, many of the hardware components on NEMO-AM are inherited from the Generic Nanosatellite Bus and likewise boast flight heritage. The satellite also employs new technologies facilitated by commercial off-the-shelf hardware. This enabled shorter design cycles, but allowed those periods to be focused more on mission specific goals. The satellite bus envelopes a volume of 20 cm x 20 cm x 40 cm (main body) and has a mass of 16.1 kg with a power throughput capability of 80W. NEMO-AM will fly a standard suite of Attitude and Orbit Control Subsystem components found on the Generic Nanosatellite Bus, a GPS receiver, communication antennas (S-band for uplink and downlink), onboard computers for task management, a power distribution network including batteries and solar cells, and a multi-spectral imager to capture aerosol concentration measurements.
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- Wild, J. A., et al.
(författare)
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Midnight sector observations of auroral omega bands
- 2011
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 116, s. A00I30-
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Tidskriftsartikel (refereegranskat)abstract
- We present observations of auroral omega bands on 28 September 2009. Although generally associated with the substorm recovery phase and typically observed in the morning sector, the features presented here occurred just after expansion phase onset and were observed in the midnight sector, dawnward of the onset region. An all-sky imager located in northeastern Iceland revealed that the omega bands were similar to 150 x 200 km in size and propagated eastward at similar to 0.4 km s(-1) while a colocated ground magnetometer recorded the simultaneous occurrence of Ps6 pulsations. Although somewhat smaller and slower moving than the majority of previously reported omega bands, the observed structures are clear examples of this phenomenon, albeit in an atypical location and unusually early in the substorm cycle. The THEMIS C probe provided detailed measurements of the upstream interplanetary environment, while the Cluster satellites were located in the tail plasma sheet conjugate to the ground-based all-sky imager. The Cluster satellites observed bursts of 0.1-3 keV electrons moving parallel to the magnetic field toward the Northern Hemisphere auroral ionosphere; these bursts were associated with increased levels of field-aligned Poynting flux. The in situ measurements are consistent with electron acceleration via shear Alfven waves in the plasma sheet similar to 8 R-E tailward of the Earth. Although a one-to-one association between auroral and magnetospheric features was not found, our observations suggest that Alfven waves in the plasma sheet are responsible for field-aligned currents that cause Ps6 pulsations and auroral brightening in the ionosphere. Our findings agree with the conclusions of earlier studies that auroral omega bands have a source mechanism in the midtail plasma sheet.
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