| 3. |
- Burchardt, Steffi, 1982-, et al.
(författare)
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Three-dimensional geometry of concentric intrusive sheet swarms in the Geitafell and the Dyrfjöll Volcanoes, Eastern Iceland
- 2011
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Ingår i: Geochemistry Geophysics Geosystems. - Washington, DC : American Geophysical Union (AGU) and the Geochemical Society. - 1525-2027. ; 12:7, s. Q0AB09-
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Tidskriftsartikel (refereegranskat)abstract
- Sheet intrusions (inclined sheets and dykes) in the deeply eroded volcanoes of Geitafell and Dyrfjöll,eastern Iceland, were studied at the surface to identify the location, depth, and size of their magmaticsource(s). For this purpose, the measured orientations of inclined sheets were projected in three dimensionsto produce models of sheet swarm geometries. For the Geitafell Volcano, the majority of sheetsconverge toward a common focal area with a diameter of at least 4 to 7 km, the location of which coincideswith several gabbro bodies exposed at the surface. Assuming that these gabbros represent part of the magmachamber feeding the inclined sheets, a source depth of 2 to 4 km below the paleoland surface is derived.A second, younger swarm of steeply dipping sheets crosscuts this gabbro and members of the first swarm.The source of this second swarm is estimated to be located to the SE of the source of Swarm 1, below thepresent‐day level of exposure and deeper than the source of the first swarm. For the Dyrfjöll Volcano,we show that the sheets can be divided into seven different subsets, three of which can be interpretedas swarms. The most prominent swarm, the Njardvik Sheet Swarm, converges toward a several kilometerswide area in the Njardvik Valley at a depth of 1.5 to 4 km below the paleoland surface. Two additionalmagmatic sources are postulated to be located to the northeast and southwest of the main source. Crosscuttingrelationships indicate contemporaneous, as well as successive activity of different magma chambers,but without a resolvable spatial trend. The Dyrfjöll Volcano is thus part of a complex volcanic cluster thatextends far beyond the study area and can serve as fossil analog for nested volcanoes such as Askja, whereasin Geitafell, the sheet swarms seem to have originated from a single focus at one time, thus defining a singlecentral volcanic complex, such as Krafla Volcano.
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| 4. |
- Jönsson, Marie E., et al.
(författare)
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Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors
- 2019
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- DNA methylation contributes to the maintenance of genomic integrity in somatic cells, in part through the silencing of transposable elements. In this study, we use CRISPR-Cas9 technology to delete DNMT1, the DNA methyltransferase key for DNA methylation maintenance, in human neural progenitor cells (hNPCs). We observe that inactivation of DNMT1 in hNPCs results in viable, proliferating cells despite a global loss of DNA CpG-methylation. DNA demethylation leads to specific transcriptional activation and chromatin remodeling of evolutionarily young, hominoid-specific LINE-1 elements (L1s), while older L1s and other classes of transposable elements remain silent. The activated L1s act as alternative promoters for many protein-coding genes involved in neuronal functions, revealing a hominoid-specific L1-based transcriptional network controlled by DNA methylation that influences neuronal protein-coding genes. Our results provide mechanistic insight into the role of DNA methylation in silencing transposable elements in somatic human cells, as well as further implicating L1s in human brain development and disease.
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