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- Bornstein, JC, et al.
(author)
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Enteric Neural Regulation of Mucosal Secretion
- 2012
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In: Physiology of the Gastrointestinal Tract. 5th Edition. Volume 1. - London : Elsevier. - 9780123820266 ; , s. 769-791
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Book chapter (peer-reviewed)abstract
- Transport of water and salt across the intestinal mucosa is a major function of the gastrointestinal tract and is regulated by the enteric nervous system. The details of this regulation vary between intestinal regions and between species. However, there are many common elements including that the major output neurons of the secretomotor pathways contain vasoactive intestinal peptide and are located in the submucosal plexus and that there are secretomotor circuits in both the myenteric and submucosal plexuses. These circuits are not simple feed-forward pathways, but include recurrent excitatory networks of intrinsic sensory neurons in both myenteric and submucosal plexuses. These neurons are excited by many sensory stimuli including major nutrients acting via mucosal enteroendocrine cells, and their excitability is enhanced in various diarrheal diseases, which often show disturbed coupling between secretion and motility, suggesting a central role for these circuits.
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