| 1. |
- Kurilshikov, Alexander, et al.
(författare)
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Large-scale association analyses identify host factors influencing human gut microbiome composition
- 2021
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 53:2, s. 156-165
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Tidskriftsartikel (refereegranskat)abstract
- To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 x 10(-8)) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 x 10(-20)), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 x 10(-10) < P < 5 x 10(-8)) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome might have causal effects in ulcerative colitis and rheumatoid arthritis.
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| 2. |
- Hansen, Malte, et al.
(författare)
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A Generic Data Model for Implementing Right of Access Requests
- 2022
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Ingår i: Privacy Technologies and Policy. - Cham : Springer. - 9783031073144 ; , s. 3-22
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Konferensbidrag (refereegranskat)abstract
- According to Article 15 of the GDPR, data subjects have theright to access personal data handled by data controllers and their pro-cessors. This raises demand for a dedicated technical service implemen-tation in order to create valid, complete, and legally compliant responsesto such requests.In this paper, we provide both a Data Request Model and a ResponseData Model for answering such requests on a technical level. While out-lining the overall process of handling such a request, we showcase a setof requirements that needs to be fulfi lled, and we discuss a set of issuescommonly arising in such an Article 15 service implementation.
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| 3. |
- Hansen, Malte Breiding
(författare)
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Between Two Ills : Homonationalism, Gender Ideology and the Case of Denmark
- 2021
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Ingår i: Redescriptions: Political Thought, Conceptual History and Feminist Theory. - : Helsinki University Press. - 2308-0914. ; 24:1, s. 60-75
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Tidskriftsartikel (refereegranskat)abstract
- This article draws on Mouffe’s theory of agonistic democracy and critique of hegemonic consensuses to examine whether and how homonationalism can come to fuel antagonisms levelled against the gender+ movements. Using discourse analysis, the article analyses the case study of Denmark, where in 2018 the anti-gender campaign openly challenged the government’s homonationalist discourse. The analysis confirms that the government’s homonationalist discourse establishes modes of exclusion from the national imaginary, which the anti-gender actors contest by articulating an antagonism levelled against the gender+ movements’ attributed queer ideology. The antagonising potential of homonationalist discursive practices is further substantiated by pointing to the ways in which the government’s discourse reinforces a liberal idea of citizenship that gives priority to liberal rights over the democratic values of popular sovereignty and participation. Conversely, the anti-gender discourse gives priority to popular sovereignty at the expense of gender minority rights. Both the governments’ and the anti-gender actors’ discourses are thus found to fall short in terms of the prescripts of an agonistic public sphere. The article therefore argues for an abandonment of homonationalist discursive practices, when manifesting as a hegemonic consensus, which reinforces a liberal idea of citizenship to install a plural agonistic public sphere concerning sexual and gender minority politics.
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| 4. |
- Hansen, Malte Breiding, et al.
(författare)
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Who Cares? The Neoliberal Turn and Changes in the Articulations of Women’s Relation to the Swedish Welfare State
- 2023
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Ingår i: NORA. - : Routledge. - 0803-8740 .- 1502-394X. ; 31:1, s. 17-31
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Tidskriftsartikel (refereegranskat)abstract
- This article aims to investigate how articulations of women’s relation to the welfare state and modes of political agency has changed in Sweden between 1977 and 2017; a period characterized by the introduction and implementation of a neoliberal political rationality. By way of discourse analysis, the article highlights the reciprocal relationship between the construction of the welfare state and women. To this end, it analyses the debates following two films that problematize women’s relation to the welfare state, Summer Paradise (1977) and Beyond Dreams (2017). The article argues that: (a) childcare as a structuring factor for women’s work is replaced by a focus on the responsibility of the individual to provide for herself; (b) gender as a structuring principle is replaced by gender as an attribute of the individual, and; (c) the relation between women and the state is individualized. As a result, the state becomes articulated as an individualized collectivity, which aims to serve the individual’s self-preservation as opposed to the state being an arena for solving societal and collective problems. We argue that the neoliberal turn has changed women’s political subjectivity from a focus on collective action to an atomization of agency against systemic gender inequalities.
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| 5. |
- Hansen, Malte, et al.
(författare)
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Introducing the Concept of Data Subject Rights as a Service Under the GDPR
- 2023
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Ingår i: Privacy Symposium 2023. - : Springer. - 9783031449390 ; , s. 17-31
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Konferensbidrag (refereegranskat)abstract
- The General Data Protection Regulation (GDPR) has introduced various data subject rights, e.g., the right of access, the right to erasure, or the right to data portability. These rights empower European individuals, the data subjects, to exercise control over their personal data stored or processed by organizations, the data controllers, in multiple ways. However, in practice, the enforcement of those rights faces several issues, as especially small- and medium-sized enterprises often lack the resources or know-how to implement a sufficient data subject rights solution. This leads to incomplete results that are not easily comprehensible for the data subjects.To address these issues we introduce the concept of Data Subject Rights as a Service (DSRaaS). The goal of the DSRaaS provider is to act as a bridge between the data subjects and data controllers, by providing the five services data subject right enforcement, authentication, data model, data logbook, and consulting. In this context, we will also look at the role that data intermediaries, introduced by the Data Governance Act, can serve in DSRaaS.
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| 6. |
- Hansen, Malte, et al.
(författare)
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Photocatalytic water oxidation at soft interfaces
- 2014
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Ingår i: CHEM SCI. - : Royal Society of Chemistry (RSC). - 2041-6520 .- 2041-6539. ; 5:7, s. 2683-2687
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Tidskriftsartikel (refereegranskat)abstract
- Molecular water oxidation catalysts have been, for the first time, co-embedded with a photosensitizer into phospholipid membranes. The functionalized small unilamellar vesicles produce molecular oxygen by photocatalysis when irradiated with visible light in aqueous buffer. The two dimensional assembly of the catalysts at the lipid-water interface mimics photoactive membranes in biology and allows photocatalytic water oxidation at very low catalyst concentrations of 500 nM, which cannot be reached in homogeneous systems. Highest TONs are obtained below the membrane's main transition temperature indicating that phase separation, clustering and a limited dynamic enhance the photocatalytic activity of the assembly. The concept of membrane co- embedding can be applied to various combinations, ratios and concentrations of photosensitizers and water oxidizing catalysts, providing a new approach for artificial photosynthesis.
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| 7. |
- Madsen, Esben Elholm, et al.
(författare)
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Motivational predictors of children's involvement in out-of-school activities : An application of a football program
- 2023
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Ingår i: Scandinavian Journal of Medicine and Science in Sports. - Chichester : Wiley-Blackwell Publishing Inc.. - 0905-7188 .- 1600-0838. ; 33:1, s. 72-83
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Tidskriftsartikel (refereegranskat)abstract
- The “11 for Health in Denmark” in-school educational football program has shown to have numerous positive physiological and psychological effects in 10- to 12-year-old schoolchildren. A key part of the successful application of the program, however, has not yet been examined, namely the motivational processes underlying participation and behavioral changes. This study examined such motivational processes (i.e., autonomous motivation, beliefs, and intentions) using the trans-contextual model (TCM) and investigated if the 11 for Health in Denmark program increased intentions to participate in physical activity (PA) outside of school in 10- to 12-year-old schoolchildren. Using a web-based questionnaire, Danish-speaking schoolchildren (N = 276 [boys, 50.4%]; Mage = 10.44, SD = 0.35) from three schools and seven classes completed TCM-based questionnaires at three time-points (weeks 0, 1, and 5) while participating in the 11 for Health in Denmark program. Single-indicator structural equation modeling was performed to examine goodness-of-fit and parameter estimates. A path analysis using maximum likelihood estimation was used to test the direct and indirect effects of the TCM model. The results partly supported a mediation sequence, as we found significant direct effects in eight of 13 motivational variables (β = −0.25–0.83, p <0.05), indirect effects in one of nine variables (β = 0.15, p < 0.01), but no effects with regard to PA behavior. Findings provide evidence for a motivational link between Danish-speaking schoolchildren's autonomous and controlled motivation from in school to out of school, and may inform future interventions promoting motivation and participation in out of school PA. © 2022 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.
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| 8. |
- Selch Larsen, Malte, et al.
(författare)
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Rotational thromboelastometry can predict the probability of bleeding events in a translational rat model of haemophilia A following gene-based FVIIa prophylaxis
- 2020
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Ingår i: Haemophilia. - : Wiley. - 1351-8216 .- 1365-2516. ; 26:1, s. 164-172
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Monitoring of clinical effectiveness of bypassing agents in haemophilia patients is hampered by the lack of validated laboratory assays. Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) have been evaluated for predicting clinical effectiveness of bypassing agents, however, with limited success.AIM: Application of a longitudinal model-based approach may allow for a quantitative characterization of the link between ROTEM parameters and the probability of bleeding events.METHODS: We analyse longitudinal data from haemophilia A rats receiving gene-based FVIIa prophylaxis in terms of total circulatory levels of FVII/FVIIa, clotting time (CT) measured using ROTEM and the probability of bleeding events.RESULTS: Using population pharmacokinetic-pharmacodynamic (PKPD) modelling, a PK-CT-repeated time-to-event (RTTE) model was developed composed of three submodels (a) a FVII/FVIIa PK model, (b) a PK-CT model describing the relationship between predicted FVIIa expression and CT and (c) a RTTE model describing the probability of bleeding events as a function of CT. The developed PK-CT-RTTE model accurately described the vector dose-dependent plasma concentration-time profile of total FVII/FVIIa and the exposure-response relationship between AAV-derived FVIIa expression and CT. Importantly, the developed model accurately described the occurrence of bleeding events over time in a quantitative manner, revealing a linear relationship between predicted change from baseline CT and the probability of bleeding events.CONCLUSION: Using PK-CT-RTTE modelling, we demonstrated that ROTEM parameters can accurately predict the probability of bleeding events in a translational animal model of haemophilia A.
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