| 1. |
- Antinyan, Vard, 1984, et al.
(författare)
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Monitoring Evolution of Code Complexity in Agile/Lean Software Development - A Case Study at Two Companies
- 2013
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Ingår i: 13th Symposium on Programming Languages and Software Tools, SPLST 2013 - Proceedings. - 9789633062289 ; , s. 1-15
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Konferensbidrag (refereegranskat)abstract
- One of the distinguishing characteristics of Agile and Lean software development is that software products “grow” with new functionality with relatively small increments. Continuous customer demands of new features and the companies’ abilities to deliver on those demands are the two driving forces behind this kind of software evolution. Despite the numerous benefits there are a number of risks associated with this kind of growth. One of the main risks is the fact that the complexity of the software product grows slowly, but over time reaches scales which makes the product hard to maintain or evolve. The goal of this paper is to present a measurement system for monitoring the growth of complexity and drawing attention when it becomes problematic. The measurement system was developed during a case study at Ericsson and Volvo Group Truck Technology. During the case study we explored the evolution of size, complexity, revisions and number of designers of two large software products from the telecom and automotive domains. The results show that two measures needed to be monitored to keep the complexity development under control - McCabe’s complexity and number of revisions.
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| 2. |
- Åberg, Anna, et al.
(författare)
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Helicobacter pylori adapts to chronic infection and gastric disease via ph-responsive baba-mediated adherence
- 2017
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Ingår i: Cell Host and Microbe. - : Elsevier BV. - 1931-3128 .- 1934-6069. ; 21:3, s. 376-389
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Tidskriftsartikel (refereegranskat)abstract
- The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease.
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| 3. |
- Andersson, Tommy, 1970-, et al.
(författare)
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All-cause mortality in 272 186 patients hospitalized with incident atrial fibrillation 1995-2008 : a Swedish nationwide long-term case-control study
- 2013
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 34:14, s. 1061-1067
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Tidskriftsartikel (refereegranskat)abstract
- Aims To evaluate long-term all-cause risk of mortality in women and men hospitalized for the first time with atrial fibrillation (AF) compared with matched controls. Methods and results A total of 272 186 patients (44% women) <= 85 years at the time of hospitalization with incidental AF 1995-2008 and 544 344 matched controls free of in-hospital diagnosis of AF were identified. Patients were followed via record linkage of the Swedish National Patient Registry and the Cause of Death Registry. Using Cox regression models, the long-term relative all-cause mortality risk, adjusted for concomitant diseases, in women vs. controls was 2.15, 1.72, and 1.44 (P < 0.001) in the age categories <= 65, 65-74, and 75-85 years, respectively. The corresponding figures for men were 1.76, 1.36, and 1.24 (P < 0.001). Among concomitant diseases, neoplasm, chronic renal failure, and chronic obstructive pulmonary disease contributed most to the increased all-cause mortality vs. controls. In patients with AF as the primary diagnosis, the relative risk of mortality was 1.63, 1.46, and 1.28 (P < 0.001) in women and 1.45, 1.17, and 1.10 (P < 0.001) in men. Conclusion Atrial fibrillation was an independent risk factor of all-cause mortality in patients with incident AF. The concomitant diseases that contributed most were found outside the thromboembolic risk scores. The highest relative risk of mortality was seen in women and in the youngest patients compared with controls, and the differences between genders in each age category were statistically significant.
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| 4. |
- Andersson, Tommy, 1970-, et al.
(författare)
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Patients without comorbidities at the time of diagnosis of atrial fibrillation : causes of death during long-term follow-up compared to matched controls
- 2017
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Ingår i: Clinical Cardiology. - : John Wiley & Sons. - 0160-9289 .- 1932-8737. ; 40:11, s. 1076-1082
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Little is known about the long-term, cause-specific mortality risk in patients without comorbidities at the time of diagnosis of atrial fibrillation (AF).METHODS: From a nation-wide registry of patients hospitalized with incident AF between 1995 and 2008 we identified 9 519 patients with a first diagnosed AF and no comorbidities at the time of AF diagnosis. They were matched with 12 468 controls. The follow-up continued until December 2008. Causes of death were classified according to the ICD-10 codes.RESULTS: During follow-up, 11.1% of patients with AF and 8.3% of controls died. Cardiovascular diseases were the most common causes of death and the only diagnoses which showed significantly higher relative risk in patients with AF than controls (HR 2.0, 95% CI 1.8-2.3), and the relative risk was significantly higher in women than in men. Stroke was a more common cause among patients with AF, 13.1% versus 9.7% (HR 2.7, 95% CI 1.8-4.0), while cerebral hemorrhage was more common among controls, 4.7% versus 10.2% (HR 0.9, 95% CI 0.6-1.5). The time from AF diagnosis to death was 6.0 ± 3.1 years.CONCLUSIONS: In patients with incident AF and no known comorbidities at the time of AF diagnosis, only cardiovascular diseases were more often causes of death as compared to controls. Women carried a significantly higher relative risk than men.
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| 5. |
- Antinyan, Vard, 1984, et al.
(författare)
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Monitoring Evolution of Code Complexity and Magnitude of Changes
- 2014
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Ingår i: Acta Cybernetica. - 0324-721X. ; 21:3, s. 367-382
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Tidskriftsartikel (refereegranskat)abstract
- Background: Complexity management has become a crucial activity in continuous software development. While the overall perceived complexity of a product grows rather insignificantly, the small units, such as functions and files, can have noticeable complexity growth with every increment of product features. This kind of evolution triggers risks of escalating fault-proneness and deteriorating maintainability. Goal: The goal of this research was to develop a measurement system which enables effective monitoring of complexity evolution. Method: An action research has been conducted in two large software development organiza-tions. We have measured three complexity and two change properties of code for two large industrial products. The complexity growth has been measured for five consecutive releases of products. Different patterns of growth have been identified and evaluated with software engi-neers in industry. Results: The results show that monitoring cyclomatic complexity evolution of functions and number of revisions of files focuses the attention of designers to potentially problematic files and functions for manual assessment and improvement. A measurement system was developed at Ericsson to support the monitoring process.
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| 6. |
- Antinyan, Vard, et al.
(författare)
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Monitoring evolution of code complexity and magnitude of changes
- 2014
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Ingår i: Acta Cybernetica. - : University of Szeged, Institute of Informatics. - 0324-721X. ; 21:3, s. 367-382
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Tidskriftsartikel (refereegranskat)abstract
- Complexity management has become a crucial activity in continuous software development. While the overall perceived complexity of a product grows rather insignificantly, the small units, such as functions and files, can have noticeable complexity growth with every increment of product features. This kind of evolution triggers risks of escalating fault-proneness and deteriorating maintainability. The goal of this research was to develop a measurement system which enables effective monitoring of complexity evolution. An action research has been conducted in two large software development organizations. We have measured three complexity and two change properties of code for two large industrial products. The complexity growth has been measured for five consecutive releases of the products. Different patterns of growth have been identified and evaluated with software engineers in industry. The results show that monitoring cyclomatic complexity evolution of functions and number of revisions of files focuses the attention of designers to potentially problematic files and functions for manual assessment and improvement. A measurement system was developed at Ericsson to support the monitoring process.
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| 7. |
- Nielsen, Lars, 1955-, et al.
(författare)
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Issues in Diagnosis, Supervision, and Safety
- 1996
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Issues concerning diagnosis, supervision and saftey are found in many technologically advanced products. There is now a trend to extend the functionality of diagnosis and supervision systems to handle more advanced situations. This report collects some of the initiatives taking place in research and some of the developments taking place in the industry.
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| 8. |
- Poci, Dritan, 1969-, et al.
(författare)
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Do Some Patients Younger Than 65 Years Old And With Incident Atrial Fibrillation Need Anticoagulation Treatment? : Conclusions From A Swedish Nationwide Registry Study
- 2018
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Konferensbidrag (refereegranskat)abstract
- Background: It is still under debate whether patients with atrial fibrillation (AF) and a low risk of cerebral infarction would benefit from anticoagulation.Objective: We aimed to assess whether younger patients with AF and lower CHA2DS2-VASc score would benefit from anticoagulation treatment.Methods: In a retrospective, nationwide cohort study, using the Swedish national registries, 59981 hospitalized patients were identified with incident AF. After exclusion of 11548 patients because of warfarin use before the AF diagnosis, or death, emigration or stroke within 30 days of AF diagnosis, the remaining 48 433 patients, among whom 27166 patients had no warfarin treatment, were, after adjustment for age, sex and year of AF diagnosis, divided according to age, sex and CHA2DS2-VASc score 0, 1, 2 and ≥3 and included in a time-varying analysis of warfarin treatment versus no treatment. Patients were followed up to 48 months after the inclusion.Results: In men <65 years and with a CHA2DS2-VASc score 2 or ≥3, the relative risk of having a stroke or cerebral infarction was lower when they received warfarin treatment, HR 0.35 (95% CI 0.18-0.69) and HR 0.37 (95% CI 0.23-0.59) respectively, as compared to HR 1.11 (95% CI 0.56-2.23) when the score was 1. Women younger than 65 years had a low relative risk when CHA2DS2-VASc score was ≥3 points, HR 0.31 (95% CI 0.16-0.59), as compared to HR 1.84 (95% CI 0.86-3.94) and HR 2.13 (95% CI 0.94-4.84) when the score was 2 and 1 respectively. The risk of intracranial bleeding was low and similar in all subgroups on anticoagulation except in the youngest men without risk factors.Conclusion: Women and men <65 years had a beneficial effect of warfarin if they had two risk factors other than age and sex, without an increased risk of bleeding. Our results support prophylactic anticoagulation treatment in patients under 65 years and a CHA2DS2-VASc score ≥2, other than age and sex.
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| 9. |
- Staron, Miroslaw, 1977, et al.
(författare)
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Measuring and Visualizing Code Stability - A Case Study at Three Companies
- 2013
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Ingår i: IWSM/Mensura, Conference proceedings, IEEE. - : IEEE.
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Konferensbidrag (refereegranskat)abstract
- Monitoring performance of software development organizations can be achieved from a number of perspectives – e.g. using such tools as Balanced Scorecards or corporate dashboards. However, automated monitoring through quantitative metrics usually gives the best cost-benefit trade-off. In this paper we present results from a study on using code stability indicators as a tool for product stability and organizational performance, conducted at three different software development companies – Ericsson AB, Saab AB Electronic Defense Systems (Saab) and Volvo Group Trucks Technology (Volvo Group). The results show that visualizing the source code changes using heatmaps and linking these visualizations to defect inflow profiles provide indicators of how stable the product under development is and whether quality assurance efforts should be directed to specific parts of the product. Observing the indicator and making decisions based on its visualization leads to shorter feedback loops between development and test, thus resulting in lower development costs, shorter lead time and increased quality. The industrial case study in the paper shows that the indicator and its visualization can show whether the modifications of software products are focused on parts of the code base or are spread widely throughout the product.
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