| 1. |
- Reitermaier, R, et al.
(författare)
-
αβγδ T cells play a vital role in fetal human skin development and immunity
- 2021
-
Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 218:4
-
Tidskriftsartikel (refereegranskat)abstract
- T cells in human skin play an important role in the immune defense against pathogens and tumors. T cells are present already in fetal skin, where little is known about their cellular phenotype and biological function. Using single-cell analyses, we identified a naive T cell population expressing αβ and γδ T cell receptors (TCRs) that was enriched in fetal skin and intestine but not detected in other fetal organs and peripheral blood. TCR sequencing data revealed that double-positive (DP) αβγδ T cells displayed little overlap of CDR3 sequences with single-positive αβ T cells. Gene signatures, cytokine profiles and in silico receptor–ligand interaction studies indicate their contribution to early skin development. DP αβγδ T cells were phosphoantigen responsive, suggesting their participation in the protection of the fetus against pathogens in intrauterine infections. Together, our analyses unveil a unique cutaneous T cell type within the native skin microenvironment and point to fundamental differences in the immune surveillance between fetal and adult human skin.
|
|
| 2. |
- Armstrong, Clare L., et al.
(författare)
-
Effect of cholesterol on the lateral nanoscale dynamics of fluid membranes
- 2012
-
Ingår i: European Biophysics Journal. - : Springer Science and Business Media LLC. - 0175-7571 .- 1432-1017. ; 41:10, s. 901-913
-
Tidskriftsartikel (refereegranskat)abstract
- Inelastic neutron scattering was used to study the effect of 5 and 40 mol% cholesterol on the lateral nanoscale dynamics of phospholipid membranes. By measuring the excitation spectrum at several lateral q (||) values (up to q (||) = 3 (-1)), complete dispersion curves were determined of gel, fluid and liquid-ordered phase bilayers. The inclusion of cholesterol had a distinct effect on the collective dynamics of the bilayer's hydrocarbon chains; specifically, we observed a pronounced stiffening of the membranes on the nanometer length scale in both gel and fluid bilayers, even though they were experiencing a higher degree of molecular disorder. Also, for the first time we determined the nanoscale dynamics in the high-cholesterol liquid-ordered phase of bilayers containing cholesterol. Namely, this phase appears to be "softer" than fluid bilayers, but better ordered than bilayers in the gel phase.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Blanco, J. A., et al.
(författare)
-
Low energy spin wave excitations in amplitude modulated magnetic structure of PrNi2Si2
- 2015
-
Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6596 .- 1742-6588. ; 663, s. 012010-012010
-
Konferensbidrag (refereegranskat)abstract
- Inelastic neutron scattering (INS) experiments and random phase approximation calculations have been used to investigate the low energy spin wave excitations in PrNi2Si2. The modulated magnitude of the ordered magnetic moments of Pr3+ ions implies that the associate, longitudinally polarized magnetic excitations are more intense and dispersive than the usual transverse spin waves. Within the random phase approximation the results are in good overall agreement with the predictions made by the model determined previously from the paramagnetic excitations. The most unusual observation is the well defined amplitude mode detected close to the magnetic Bragg point existing simultaneously with the phason mode. At low energies, an extra mode is observed to hybridize with the magnetic phasons in the neighborhood of the magnetic Brillouin zone center. A magnetoelastic interaction between the magnetic excitations and the longitudinal phonons is able to explain part of the disturbances, but it is concluded that the extra mode must be of some other, unknown origin.
|
|
| 6. |
- Hiess, Arno, et al.
(författare)
-
Signature of superconductivity in UBe13 as seen by neutron scattering: Superconducting and magnetic energy scales
- 2014
-
Ingår i: Physical Review B (Condensed Matter and Materials Physics). - 1098-0121. ; 89:23
-
Tidskriftsartikel (refereegranskat)abstract
- We here present inelastic neutron scattering results on the strongly correlated cubic superconductor UBe13 (T-c = 0.85 K) obtained on a large single crystal by high-resolution cold neutron three-axis spectroscopy. We observed spin dynamics at a unique momentum space position building up below T similar to 50 K and changing significantly on entering the superconducting state. The observed short-range longitudinal character of the correlations can be understood as a result of competing magnetic interactions. The energy dependence in the normal state reflects the energy scales determined from specific heat, whereas the low-temperature data suggest the opening of a superconducting gap. Our findings are consistent with a superconducting order parameter exhibiting s +/- or d-wave symmetry and placing pure UBe13 in the strong coupling regime.
|
|
| 7. |
- Lim, J. A., et al.
(författare)
-
Unexpected phase locking of magnetic fluctuations in the multi-k magnet USb
- 2013
-
Ingår i: Physical Review B (Condensed Matter and Materials Physics). - 1098-0121. ; 87:6
-
Tidskriftsartikel (refereegranskat)abstract
- The spin waves in the multi-k antiferromagnet USb soften and become quasielastic well below the antiferromagnetic ordering temperature T-N. This occurs without a magnetic or structural transition. It has been suggested that this change is in fact due to dephasing of the different multi-k components: a switch from 3-k to 1-k behavior. In this work, we use inelastic neutron scattering with tridirectional polarization analysis to probe the quasielastic magnetic excitations and reveal that the 3-k structure does not dephase. More surprisingly, the paramagnetic correlations also maintain the same clear phase correlations well above T-N ( up to at least 1.4T(N)). DOI: 10.1103/PhysRevB.87.064421
|
|
