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| 2. |
- Wang, QBS, et al.
(författare)
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The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force
- 2022
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 4830-
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Tidskriftsartikel (refereegranskat)abstract
- Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection.
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| 3. |
- Yoshida, Tsuyoshi, 1982, et al.
(författare)
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Compressed Shaping: Concept and FPGA Demonstration
- 2021
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Ingår i: Journal of Lightwave Technology. - 0733-8724 .- 1558-2213. ; 39:17, s. 5412-5422
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Tidskriftsartikel (refereegranskat)abstract
- Probabilistic shaping (PS) has been widely studied and applied to optical fiber communications. The encoder of PS expends the number of bit slots and controls the probability distribution of channel input symbols. Not only studies focused on PS but also most works on optical fiber communications have assumed source uniformity (i.e. equal probability of marks and spaces) so far. On the other hand, the source information is in general nonuniform, unless bit-scrambling or other source coding techniques to balance the bit probability is performed. Interestingly, one can exploit the source nonuniformity to reduce the entropy of the channel input symbols with the PS encoder, which leads to smaller required signal-to-noise ratio at a given input logic rate. This benefit is equivalent to a combination of data compression and PS, and thus we call this technique compressed shaping. In this work, we explain its theoretical background in detail, and verify the concept by both numerical simulation and a field programmable gate array (FPGA) implementation of such a system. In particular, we find that compressed shaping can reduce power consumption in forward error correction decoding by up to 90% in nonuniform source cases. The additional hardware resources required for compressed shaping are not significant compared with forward error correction coding, and an error insertion test is successfully demonstrated with the FPGA.
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| 5. |
- Yoshida, Tsuyoshi, 1982, et al.
(författare)
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Low-Complexity Symbol Demapping for Multidimensional Multilevel Coded Modulation
- 2022
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Ingår i: European Conference on Optical Communication, ECOC. ; , s. 1-4
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Konferensbidrag (refereegranskat)abstract
- Symbol demapping for multidimensional multilevel coding (MLC) is proposed, together with a novel nonsystematic encoding method, applicable to any dimensionality. The complexity of soft-decision forward error correction and symbol demapping, both normally problematic in multidimensional MLC, is reduced, which enables high-throughput implementation.
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| 6. |
- Yoshida, Tsuyoshi, 1982, et al.
(författare)
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Nonlinear Fiber Transmission of Compressed Shaping Signals
- 2022
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Ingår i: 2022 European Conference on Optical Communication, ECOC 2022. - 9781957171159 ; , s. 1-4
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Konferensbidrag (refereegranskat)abstract
- In nonlinear transmission of compressed shaping signals, the optimum launch power decreases as source entropy decreases, but the maximum Q performance based on soft information increases for either bit-interleaved coded or multilevel coded modulation. The excess degradation is mostly recovered by high-performance multi-channel nonlinearity compensation.
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| 7. |
- Yoshida, Tsuyoshi, et al.
(författare)
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Required and received SNRs in coded modulation
- 2020
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Ingår i: European Conference on Optical Communication, ECOC.
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Konferensbidrag (refereegranskat)abstract
- Coded modulation techniques aim at reducing the required signal-to-noise ratio (SNR) over the Gaussian channel with an average energy constraint; however, such techniques tend to degrade the received SNR. We studied the balance of required and received SNRs for a realistic system design.
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| 8. |
- Yoshida, Tsuyoshi, et al.
(författare)
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Sparse-dense MLC for peak power constrained channels
- 2020
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Ingår i: European Conference on Optical Communication, ECOC.
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Konferensbidrag (refereegranskat)abstract
- Probabilistic amplitude shaping with Maxwell-Boltzmann distributions can degrade system budgets due to a large peak-to-average power ratio at a low spectral efficiency and at a short reach transmission with few optical amplifiers. We propose a novel coded modulation technique, which is useful in such scenarios.
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