| 1. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 2. |
- Ghobakhloo, Morteza, et al.
(författare)
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Blockchain technology as an enabler for sustainable business ecosystems : A comprehensive roadmap for socioenvironmental and economic sustainability
- 2024
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Ingår i: Business strategy and development. - : John Wiley & Sons. - 2572-3170. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- Blockchain technology is a core technology expected to play a highly instrumental role in competing with socioenvironmental challenges. The literature hypothesizes various blockchain functions for building a sustainable business ecosystem. This study unifies these diverse perspectives into an interpretive strategy roadmap that provides a holistic overview of how blockchain should be leveraged to deliver sustainability functions optimally. The study first identified the sustainability functions of blockchain through a content-centric literature review. The study applied interpretive structural modeling (ISM) and drew on experts' opinions to model how and in which order blockchain delivers these sustainability functions. The study further drew on the ISM output and interpretive logic-knowledge base to develop the promised roadmap. Results revealed that blockchain promotes a decentralized decision system that facilitates automation and real-time information sharing (RIS) across supply chains. Blockchain introduces traceability and transparency into supply chain operations. These conditions offer monitoring of business operations and the development of trust across value-chain stakeholders. These driver functions lead to value chain optimization and circularity integration into business and supply chain operations. When these necessary functional conditions are met, businesses can further draw on blockchain to promote economic and environmental aspects of sustainability through more complex functions enabling resource efficiency, cost reduction, pollution prevention, and higher profit margins. The order in which businesses can leverage these functions would define blockchain sustainability performance. Each function is uniquely valuable to sustainability, and none of them can be overlooked.
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| 3. |
- Ghobakhloo, Morteza, et al.
(författare)
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Industry 4.0 digital transformation and opportunities for supply chain resilience : a comprehensive review and a strategic roadmap
- 2023
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Ingår i: Production planning & control (Print). - : Taylor & Francis. - 0953-7287 .- 1366-5871. ; , s. 1-31
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Tidskriftsartikel (refereegranskat)abstract
- Despite interest in opportunities that Industry 4.0 offers for Supply Chain Resilience (SCR), little is known about the underlying mechanisms for such contributions. The study develops a roadmap that explains how supply chains can capitalize on Industry 4.0 SCR functions. The study conducted a content-centric literature review and identified 16 functions through which Industry 4.0 enhances SCR. Results reveal that the Industry 4.0 SCR functions identified are highly interrelated, and supply chain members should align their digitalization strategies with the sequence in which Industry 4.0 delivers these functions. Industry 4.0 contribution to SCR first involves delivering data-centric functions such as supply chain automation, information and communication quality, process monitoring, and visibility. Industry 4.0 further allows supply chain partners to collaborate better on improving supply chain mapping, complexity management, and innovation capabilities. Through these functions and by increasing transparency, flexibility, and agility of supply chain operations, Industry 4.0 delivers more dependent but consequential resilience functions such as supply chain responsiveness, adaptive capability, and continuity management. The roadmap further explains how each pair of Industry 4.0 SCR functions mutually interact while contributing to the overall resilience of the supply chain. The study discusses possible implications and outlines important avenues for future research.
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| 4. |
- Khanfar, Ahmad A. A., et al.
(författare)
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Applications of Blockchain Technology in Sustainable Manufacturing and Supply Chain Management : A Systematic Review
- 2021
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Ingår i: Sustainability. - : MDPI. - 2071-1050. ; 13:14, s. 1-20
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Forskningsöversikt (refereegranskat)abstract
- Developing sustainable products and processes is essential for the survival of manufacturers in the current competitive market and the industry 4.0 era. The activities of manufacturers andtheir supply chain partners should be aligned with sustainable development goals. Manufacturershave faced many barriers and challenges in implementing sustainable practices along the entiresupply chain due to globalisation, outsourcing, and offshoring. Blockchain technology has thepotential to address the challenges of sustainability. This study aims to explain the applications ofblockchain technology to sustainable manufacturing. We conducted a systematic literature reviewand explained the potential contributions of blockchain technology to the economic, environmental,and social performances of manufacturers and their supply chains. The findings of the study extendour understanding of the blockchain applications in sustainable manufacturing and sustainablesupply chains. Furthermore, the study explains how blockchain can influence the sustainable performance of manufacturers by creating transparency, traceability, real-time information sharing, andsecurity of the data capabilities.
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| 5. |
- Faridi, M. A., et al.
(författare)
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Microbubble assisted cell sorting by acoustophoresis
- 2016
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Ingår i: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. - : Chemical and Biological Microsystems Society. - 9780979806490 ; , s. 1677-1678
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Konferensbidrag (refereegranskat)abstract
- Polymer shelled gas microbubbles (MBs) are used to sort cells in a microfluidic chip under acoustic standing waves (SW). When particles are subjected to SW based on their acoustic contrast factor (ACF) they migrate to nodes (positive contrast factor particles; PACP) or antinodes (negative acoustic contrast particles; NACP)[1]. We have bounded functionalized MBs with cells such that, they can be selectively migrated to antinodes under SW and sorted from unbounded cell both in no flow and flow conditions. Here we demonstrate acoustic mediated microbubble tagged cell sorting with 75% efficiency.
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| 6. |
- Kennedy, Aaron D.W., et al.
(författare)
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Diastereoselective Control of Tetraphenylethene Reactivity by Metal Template Self-Assembly
- 2019
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Ingår i: Chemistry - A European Journal. - : Wiley. - 1521-3765 .- 0947-6539. ; 25:22, s. 5708-5718
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Tidskriftsartikel (refereegranskat)abstract
- The reaction of 4,4′,4′′,4′′′-(ethene-1,1,2,2-tetrayl)tetraaniline with 2-pyridinecarboxaldehyde and iron(II) chloride resulted, after aqueous workup, in the diastereoselective formation of an [Fe 2 L 3 ] 4+ triple-stranded helicate structure, irrespective of the stoichiometry employed. The helicate structure was characterized in solution by multinuclear NMR spectroscopy, and in the solid state by single-crystal X-ray crystallography. The reaction of iron(II) tetrafluoroborate or iron(II) bistriflimide with the tetraaniline and 2-pyridinecarboxaldehyde allowed the formation of an [Fe 8 L 6 ] 16+ cube when the appropriate stoichiometry was used, but these structures were unstable with respect to hydrolysis. The pendant amine groups on the helicate can be functionalized by reaction with acid chlorides or anhydrides, and the resulting functionalized tetraphenylethene (TPE) units were isolated by the reaction of the helicate with tris(2-aminoethyl)amine. The emission properties of the TPE units were studied in THF/water mixtures, and they were found by dynamic light scattering to self-assemble into large (av. diameter 250 nm) structures.
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