| 1. |
- Jansson, Johan, 1978-, et al.
(författare)
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Simulation of 3D unsteady incompressible flow past a NACA 0012 wing section
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- We present computational simulations of three-dimensional unsteady high Reynolds number incompressible flow past a NACA 0012 wing profile, for a range of angles of attack, from low lift through stall. A stabilized finite element method is used, referred to as General Galerkin (G2), with adaptive mesh refinement with respect to the error in target output, such as aerodynamic forces. Computational predictions of aerodynamic forces are validated against experimental data.
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| 2. |
- Jansson, Johan, 1978-, et al.
(författare)
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Time-resolved Adaptive Direct FEM Simulation of High-lift Aircraft Configurations : Chapter in "Numerical Simulation of the Aerodynamics of High-Lift Configurations'", Springer
- 2018
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Ingår i: Numerical Simulation of the Aerodynamics of High-Lift Configurations. - Cham : Springer. - 9783319621364 - 9783319621357 ; , s. 67-92
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Bokkapitel (refereegranskat)abstract
- We present an adaptive finite element method for time-resolved simulation of aerodynamics without any turbulence-model parameters, which is applied to a benchmark problem from the HiLiftPW-3workshop to compute the flowpast a JAXA Standard Model (JSM) aircraft model at realistic Reynolds numbers. The mesh is automatically constructed by the method as part of an adaptive algorithm based on a posteriori error estimation using adjoint techniques. No explicit turbulence model is used, and the effect of unresolved turbulent boundary layers is modeled by a simple parametrization of the wall shear stress in terms of a skin friction. In the case of very high Reynolds numbers, we approximate the small skin friction by zero skin friction, corresponding to a free-slip boundary condition, which results in a computational model without any model parameter to be tuned, and without the need for costly boundary-layer resolution. We introduce a numerical tripping-noise term to act as a seed for growth of perturbations; the results support that this triggers the correct physical separation at stall and has no significant pre-stall effect. We show that the methodology quantitavely and qualitatively captures the main features of the JSM experiment-aerodynamic forces and the stall mechanism-with a much coarser mesh resolution and lower computational cost than the state-of-the-art methods in the field, with convergence under mesh refinement by the adaptive method. Thus, the simulation methodology appears to be a possible answer to the challenge of reliably predicting turbulent-separated flows for a complete air vehicle.
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| 3. |
- Jansson, Johan, 1978-, et al.
(författare)
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Adaptive error control in finite element methods using the error representation as error indicator
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In this paper we present a new a posteriori adaptive finite elementmethod (FEM) directly using the error representation as a local errorindicator, and representing the primal and dual solutions in the samefinite element space (here piecewise continuous linear functions onthe same mesh). Since this approach gives a global a posteriori errorestimate that is zero (due to the Galerkin orthogonality), the errorrepresentation has historically been thought to contain no informationabout the error. However, we show the opposite, that locally, theorthogonal error representation behaves very similar to thenon-orthogonal error representation using a quadratic approximation ofthe dual. We present evidence of this both in the form of an a prioriestimate for the local error indicator and a detailed computationalinvestigation showing that the two methods exhibit very similarbehavior and performance, and thus confirming the theoreticalprediction. We also present a stabilized version of the method fornon-elliptic partial differential equations (PDE) where the errorrepresentation is no longer orthogonal, and where both the local errorindicator and global error estimate behave similar to the errorrepresentation using a quadratic approximation of the dual.
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| 4. |
- Jansson, Johan, 1978-, et al.
(författare)
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Automated adaptive error control in finite element methods using the error representation as error indicator
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In this paper we present a new adaptive finite element method directly using the a posteriori error representation as a local error indicator, and representing the primal and dual solutions in the same finite element space (here piecewise continuous linear functions on the same mesh). Since this approach gives a global a posteriori error estimate that is zero (due to Galerkin orthogonality), the error representation has traditionally been thought to contain no information about the error. However, we show the opposite, that locally, the orthogonal error representation behaves very similar to the non-orthogonal error representation using a higher order approximation of the dual, which is a standard approach to overcome the problem of a zero error estimate. We present evidence of this both in the form of an a priori estimate for the local error indicator for an elliptic model problem and a detailed computational investigation showing that the two methods exhibit very similar behavior and performance, and thus confirming the theoretical prediction. We also present computational results using a stabilized version of the method for non-elliptic partial differential equations where the error representation is no longer orthogonal, and where both the local error indicator and global error estimate behave similar to the error representation using a higher order approximation of the dual. The benefits of this adaptive method are generality and simplicity in formulation, sharpness, and efficiency since high order approximation of the dual and computation of additional constructs such as jump terms over interior facets or local problems are avoided.
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| 5. |
- Jansson, Johan, 1978-, et al.
(författare)
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Automated error control in finite element methods withapplications in fluid flow
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In this paper we present a new adaptive finite element method for thesolution of linear and non-linear partial differential equationsdirectly using the a posteriori error representation as a local errorindicator, with the primal and dual solutions approximated in the samefinite element space, here piecewise continuous linear functions onthe same mesh. Since this approach gives a global a posteriori errorrepresentation that is zero due to Galerkin orthogonality, the errorrepresentation has traditionally been thought to contain noinformation about the error. However, for elliptic andconvection-diffusion model problems we show the opposite, that locallythe orthogonal error representation behaves very similar to thenon-orthogonal error representation using a higher order approximationof the dual. We have previously proved an a priori estimate of thelocal error indicator for elliptic problems, and in this paper weextend the proof to convection-reaction problems. We also present aversion of the method for non-elliptic and non-linear problems using astabilized finite element method where the a posteriori errorrepresentation is no longer orthogonal. We apply this method to thestationary incompressible Navier-Stokes equation and perform detailednumerical experiments which show that the a posteriori error estimateis within a factor 2 of the error based on a reference value on a finemesh, except in a few data points on very coarse meshes for anon-smooth test case where it is within a factor 3.
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| 6. |
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| 7. |
- Jansson, Johan, 1978-, et al.
(författare)
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Direct finite element simulation of turbulent flow for marine based renewable energy
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In this article we present a computational framework for simulation ofturbulent flow in marine based renewable energy applications. Inparticular, we focus on floating structures and rotatingturbines. This work is an extension to multiphase turbulent flow, ofour existing framework of residual based turbulence modeling forsingle phase turbulent incompressible flow. We illustrate theframework in four examples: a regular wave test where we compareagainst an exact solution, the standard MARIN wave impact benchmarkwith experimental validation data, a vertical axis turbine withcomplex geometry from an existing turbine, and finally a prototypesimulation of decay test in a coupled moving boundary rigid-body andtwo-phase fluid simulation.
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| 8. |
- Jansson, Johan, 1978-, et al.
(författare)
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Gestural 3D Interaction with a Beating Heart : Simulation Visualization and Interaction
- 2011
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Ingår i: Proceedings of SIGRAD 2011. - : Linköping University Electronic Press. - 9789173930086
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Konferensbidrag (refereegranskat)abstract
- The KTH School of Computer Science and Communication (CSC) established a strategic platform in Simulation-Visualization-Interaction (SimVisInt) in 2009, focused on the high potential in bringing together CSC core com-petences in simulation technology, visualization and interaction. The main part of the platform takes the form aset of new trans-disciplinary projects across established CSC research groups, within the theme of ComputationalHuman Modeling and Visualization: (i) interactive virtual biomedicine (HEART), (ii) simulation of human mo-tion (MOTION), and (iii) virtual prototyping of human hand prostheses (HAND). In this paper, we present recentresults from the HEART project that focused on gestural and haptic interaction with a heart simulation.
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| 9. |
- Jansson, Malin, 1978-, et al.
(författare)
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Stromal type I collagen in breast cancer : correlation to prognostic biomarkers and prediction of chemotherapy response
- 2024
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Ingår i: Clinical Breast Cancer. - : Elsevier. - 1526-8209 .- 1938-0666.
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Fibrillar collagens accumulate in the breast cancer stroma and appear as poorly defined spiculated masses in mammography imaging. The prognostic value of tissue type I collagen remains elusive in treatment-naïve and chemotherapy-treated breast cancer patients. Here, type I collagen mRNA and protein expression were analysed in 2 large independent breast cancer cohorts. Levels were related to clinicopathological parameters, prognostic biomarkers, and outcome.Method: COL1A1 mRNA expression was analysed in 2509 patients with breast cancer obtained from the cBioPortal database. Type I collagen protein expression was studied by immunohistochemistry in 1395 women diagnosed with early invasive breast cancer.Results: Low COL1A1 mRNA and protein levels correlated with poor prognosis features, such as hormone receptor negativity, high histological grade, triple-negative subtype, node positivity, and tumour size. In unadjusted analysis, high stromal type I collagen protein expression was associated with improved overall survival (OS) (HR = 0.78, 95% CI = 0.61-0.99, p = .043) and trended towards improved breast cancer–specific survival (BCSS) (HR = 0.65, 95% CI = 0.42-1.01, P = 0.053), although these findings were lost after adjustment for other clinical variables. In unadjusted analysis, high expression of type I collagen was associated with better OS (HR = 0.70, 95% CI = 0.55-0.90, P = .006) and BCSS (HR = 0.55, 95% CI = 0.34-0.88, P = .014) among patients not receiving chemotherapy. Strikingly, the opposite was observed among patients receiving chemotherapy. There, high expression of type I collagen was instead associated with worse OS (HR = 1.83, 95% CI = 0.65-5.14, P = .25) and BCSS (HR = 1.72, 95% CI = 0.54-5.50, P = .357).Conclusion: Low stromal type I collagen mRNA and protein expression are associated with unfavourable tumour characteristics in breast cancer. Stromal type I collagen might predict chemotherapy response.
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| 10. |
- Naeser, Ylva, et al.
(författare)
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TRIM study protocol - a prospective randomized multicenter Trial to assess the Role of Imaging during follow-up after radical surgery of stage IIB-C and III cutaneous malignant Melanoma
- 2020
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Ingår i: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe incidence of cutaneous malignant melanoma (CMM) is increasing worldwide. In Sweden, over 4600 cases were diagnosed in 2018. The prognosis after radical surgery varies considerably with tumor stage. In recent years, new treatment options have become available for metastatic CMM. Early onset of treatment seems to improve outcome, which suggests that early detection of recurrent disease should be beneficial. Consequently, in several countries imaging is a part of the routine follow-up program after surgery of high risk CMM. However, imaging has drawbacks, including resources required (costs, personnel, equipment) and the radiation exposure. Furthermore, many patients experience anxiety in waiting for the imaging results and investigations of irrelevant findings is another factor that also could cause worry and lead to decreased quality of life. Hence, the impact of imaging in this setting is important to address and no randomized study has previously been conducted. The Swedish national guidelines stipulate follow-up for 3years by clinical examinations only.MethodsThe TRIM study is a prospective randomized multicenter trial evaluating the potential benefit of imaging and blood tests during follow-up after radical surgery for high-risk CMM, compared to clinical examinations only. Primary endpoint is overall survival (OS) at 5years. Secondary endpoints are survival from diagnosis of relapse and health-related quality of life (HRQoL). Eligible for inclusion are patients radically operated for CMM stage IIB-C or III with sufficient renal function for iv contrast-enhanced CT and who are expected to be fit for treatment in case of recurrence. The planned number of patients is >1300. Patients are randomized to clinical examinations for 3years +/- whole-body imaging with CT or FDG-PET/CT and laboratory tests including S100B protein and LDH. This academic study is supported by the Swedish Melanoma Study Group.DiscussionThis is the first randomized prospective trial on the potential benefit of imaging as a part of the follow-up scheme after radical surgery for high-risk CMM.ResultsThe first patient was recruited in June 2017 and as of April 2020, almost 500 patients had been included at 19 centers in Sweden.Trial registrationClinicalTrials.gov, NCT 03116412. Registered 17 April 2017, https://clinicaltrials.gov/ct2/show/study/NCT03116412
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