| 1. |
|
|
| 2. |
- Santangelo, James S., et al.
(författare)
-
Global urban environmental change drives adaptation in white clover
- 2022
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375
-
Tidskriftsartikel (refereegranskat)abstract
- Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural dines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale.
|
|
| 3. |
|
|
| 4. |
- Cozen, W., et al.
(författare)
-
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus
- 2014
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5, s. 3856-
-
Tidskriftsartikel (refereegranskat)abstract
- Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR) = 0.81, 95% confidence interval (95% CI) = 0.76-0.86, P-combined 3.5 x 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B-and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.
|
|
| 5. |
- de Blok, W.J.G., et al.
(författare)
-
an overview of the MHONGOOSE survey: Observing nearby galaxies with MeerKAT
- 2016
-
Ingår i: Proceedings of Science. - 1824-8039.
-
Konferensbidrag (refereegranskat)abstract
- MHONGOOSE is a deep survey of the neutral hydrogen distribution in a representative sample of 30 nearby disk and dwarf galaxies with H I masses from ∼ 106 to ∼ 1011 M, and luminosities from MR ∼ 12 to MR ∼ −22. The sample is selected to uniformly cover the available range in log(MHI). Our extremely deep observations, down to H I column density limits of well below 1018 cm−2 — or a few hundred times fainter than the typical H I disks in galaxies — will directly detect the effects of cold accretion from the intergalactic medium and the links with the cosmic web. These observations will be the first ever to probe the very low-column density neutral gas in galaxies at these high resolutions. Combination with data at other wavelengths, most of it already available, will enable accurate modeling of the properties and evolution of the mass components in these galaxies and link these with the effects of environment, dark matter distribution, and other fundamental properties such as halo mass and angular momentum. MHONGOOSE can already start addressing some of the SKA-1 science goals and will provide a comprehensive inventory of the processes driving the transformation and evolution of galaxies in the nearby universe at high resolution and over 5 orders of magnitude in column density. It will be a Nearby Galaxies Legacy Survey that will be unsurpassed until the advent of the SKA, and can serve as a highly visible, lasting statement of MeerKAT’s capabilities.
|
|
| 6. |
- Sakornsakolpat, Phuwanat, et al.
(författare)
-
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
- 2019
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 51:3, s. 494-505
-
Tidskriftsartikel (refereegranskat)abstract
- Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P < 5 x 10-8; 47 of these were previously described in association with either COPD or population-based measures of lung function. Of the remaining 35 new loci, 13 were associated with lung function in 79,055 individuals from the SpiroMeta consortium. Using gene expression and regulation data, we identified functional enrichment of COPD risk loci in lung tissue, smooth muscle, and several lung cell types. We found 14 COPD loci shared with either asthma or pulmonary fibrosis. COPD genetic risk loci clustered into groups based on associations with quantitative imaging features and comorbidities. Our analyses provide further support for the genetic susceptibility and heterogeneity of COPD.
|
|
| 7. |
|
|
| 8. |
- Berndt, Sonja, I, et al.
(författare)
-
Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
- 2022
-
Ingår i: Leukemia. - : Springer Nature. - 0887-6924 .- 1476-5551. ; 36:12, s. 2835-2844
-
Tidskriftsartikel (refereegranskat)abstract
- Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10−8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10−9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10−8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.
|
|
| 9. |
|
|
| 10. |
- Asabere, B. D., et al.
(författare)
-
Mid-infrared dust in two nearby radio galaxies, NGC 1316 (Fornax A) and NGC 612 (PKS 0131-36)
- 2016
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 592:A20, s. 1-16
-
Tidskriftsartikel (refereegranskat)abstract
- Context. Most radio galaxies are hosted by giant gas-poor ellipticals, but some contain significant amounts of dust, which is likely to be of external origin. Aims. In order to characterize the mid-IR properties of two of the most nearby and brightest merger-remnant radio galaxies of the Southern hemisphere, NGC 1316 (Fornax A) and NGC 612 (PKS 0131-36), we used observations with the Wide-field Infrared Survey Explorer (WISE) at wavelengths of 3.4, 4.6, 12 and 22 mu m and Spitzer mid-infrared spectra. Methods. By applying a resolution-enhancement technique, new WISE images were produced at angular resolutions ranging from 2 ''.6 to 5 ''.5. Global measurements were performed in the four WISE bands, and stellar masses and star-formation rates were estimated using published scaling relations. Two methods were used to uncover the distribution of dust, one relying on two-dimensional fits to the 3.4 mu m images to model the starlight, and the other one using a simple scaling and subtraction of the 3.4 mu m images to estimate the stellar continuum contribution to the emission in the 12 and 22 mu m bands. Results. The two galaxies differ markedly in their mid-IR properties. The 3.4 mu m brightness distribution can be well represented by the superposition of two Sersic models in NGC 1316 and by a Sersic model and an exponential disk in NGC 612. The WISE colors of NGC 1316 are typical of those of early-type galaxies; those of NGC 612 are in the range found for star-forming galaxies. From the 22 mu m luminosity, we infer a star-formation rate of similar to 0.7 M-circle dot yr(-1) in NGC 1316 and similar to 7 M-circle dot yr(-1) in NGC 612. Spitzer spectroscopy shows that the 7.7-to-11.3 mu m PAH line ratio is significantly lower in NGC 1316 than in NGC 612. The WISE images reveal resolved emission from dust in the central 1'-2' of the galaxies. In NGC 1316, the extra-nuclear emission coincides with two dusty regions NW and SE of the nucleus seen in extinction in optical images and where molecular gas is known to reside. In NGC 612 it comes from a warped disk. This suggests a recent infall onto NGC 1316 and disruption of one or several smaller gas-rich galaxies, but a smoother accretion in NGC 612. While the nucleus of NGC 1316 is currently dormant and the galaxy is likely to evolve into a passive elliptical, NGC 612 has the potential of growing a larger disk and sustaining an active nucleus. Conclusions. NGC 1316 and NGC 612 represent interesting challenges to models of formation and evolution of galaxies and AGNs.
|
|
