| 1. |
- Niu, Mengyao, et al.
(författare)
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Fungal oxylipins direct programmed developmental switches in filamentous fungi
- 2020
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Ingår i: Nature Communications. - : NATURE RESEARCH. - 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Filamentous fungi differentiate along complex developmental programs directed by abiotic and biotic signals. Currently, intrinsic signals that govern fungal development remain largely unknown. Here we show that an endogenously produced and secreted fungal oxylipin, 5,8-diHODE, induces fungal cellular differentiation, including lateral branching in pathogenic Aspergillus fumigatus and Aspergillus flavus, and appressorium formation in the rice blast pathogen Magnaporthe grisea. The Aspergillus branching response is specific to a subset of oxylipins and is signaled through G-protein coupled receptors. RNA-Seq profiling shows differential expression of many transcription factors in response to 5,8-diHODE. Screening of null mutants of 33 of those transcription factors identifies three transcriptional regulators that appear to mediate the Aspergillus branching response; one of the mutants is locked in a hypo-branching phenotype, while the other two mutants display a hyper-branching phenotype. Our work reveals an endogenous signal that triggers crucial developmental processes in filamentous fungi, and opens new avenues for research on the morphogenesis of filamentous fungi.
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| 2. |
- Qiao, Mengyao, et al.
(författare)
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60 Gbit/s PAM-4 wireless transmission in the 310 GHz band with nonlinearity tolerant signal processing
- 2021
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Ingår i: Optics Communications. - : Elsevier BV. - 0030-4018 .- 1873-0310. ; 492
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Tidskriftsartikel (refereegranskat)abstract
- We experimentally demonstrate a terahertz (THz) photonic wireless transmission system in the 310 GHz band with four-level pulse amplitude modulation (PAM-4) signals. A zero-bias diode is used as a simple direct detection receiver, which is cost-effective compared to a conventional coherent receiver. Moreover, we comprehensively investigate the system performance by applying linear and nonlinear equalization schemes. The experimental results show that Volterra nonlinear filtering can significantly improve the system capacity by around 90%, and transmissions of up to 60 Gbit/s PAM-4 signals over a 3 m wireless link are successfully achieved. The advantageous features of this make it promising for high-speed THz wireless communications.
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| 3. |
- Smith, Siobhan, et al.
(författare)
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IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation
- 2018
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Ingår i: JCI Insight. - : American Society for Clinical Investigation. - 2379-3708. ; 3:15
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Tidskriftsartikel (refereegranskat)abstract
- Severe lung inflammation and alveolar hemorrhage can be life-threatening in systemic lupus erythematosus (SLE) patients if not treated early and aggressively. Neutrophil influx is the driver key of this pathology, but little is known regarding the molecular events regulating this recruitment. Here, we uncover a role for IL-16/mir-125a in this pathology and show not only that IL-16 is a target for miR-125a but that reduced miR-125a expression in SLE patients associates with lung involvement. Furthermore, in the pristane model of acute "SLE-like" lung inflammation and alveolar hemorrhage, we observed reduced pulmonary miR-125a and enhanced IL-16 expression. Neutrophil infiltration was markedly reduced in the peritoneal lavage of pristane-treated IL-16-deficient mice and elevated following i.n. delivery of IL-16. Moreover, a miR-125a mimic reduced pristane-induced IL-16 expression and neutrophil recruitment and rescued lung pathology. Mechanistically, IL-16 acts directly on the pulmonary epithelium and markedly enhances neutrophil chemoattractant expression both in vitro and in vivo, while the miR-125a mimic can prevent this. Our results reveal a role for miR-125a/IL-16 in regulating lung inflammation and suggest this axis may be a therapeutic target for management of acute lung injury in SLE.
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