| 1. |
- Johansson, Maria U, et al.
(author)
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Structure, specificity, and mode of interaction for bacterial albumin-binding modules.
- 2002
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In: Journal of Biological Chemistry. - 1083-351X .- 0021-9258. ; 277:10, s. 8114-8120
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Journal article (peer-reviewed)abstract
- We have determined the solution structure of an albumin binding domain of protein G, a surface protein of group C and G streptococci. We find that it folds into a left handed three-helix bundle similar to the albumin binding domain of protein PAB from Peptostreptococcus magnus. The two domains share 59% sequence identity, are thermally very stable, and bind to the same site on human serum albumin. The albumin binding site, the first determined for this structural motif known as the GA module, comprises residues spanning the first loop to the beginning of the third helix and includes the most conserved region of GA modules. The two GA modules have different affinities for albumin from different species, and their albumin binding patterns correspond directly to the host specificity of C/G streptococci and P. magnus, respectively. These studies of the evolution, structure, and binding properties of the GA module emphasize the power of bacterial adaptation and underline ecological and medical problems connected with the use of antibiotics.
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| 2. |
- Austeng, Dordi, et al.
(author)
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Incidence of and risk factors for neonatal morbidity after active perinatal care : extremely preterm infants study in Sweden (EXPRESS)
- 2010
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In: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 99:7, s. 978-992
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Journal article (peer-reviewed)abstract
- Aims: The aim of this study was to determine the incidence of neonatal morbidity in extremely preterm infants and to identify associated risk factors. Methods: Population based study of infants born before 27 gestational weeks and admitted for neonatal intensive care in Sweden during 2004-2007. Results: Of 638 admitted infants, 141 died. Among these, life support was withdrawn in 55 infants because of anticipation of poor long-term outcome. Of 497 surviving infants, 10% developed severe intraventricular haemorrhage (IVH), 5.7% cystic periventricular leucomalacia (cPVL), 41% septicaemia and 5.8% necrotizing enterocolitis (NEC); 61% had patent ductus arteriosus (PDA) and 34% developed retinopathy of prematurity (ROP) stage >= 3. Eighty-five per cent needed mechanical ventilation and 25% developed severe bronchopulmonary dysplasia (BPD). Forty-seven per cent survived to one year of age without any severe IVH, cPVL, severe ROP, severe BPD or NEC. Tocolysis increased and prolonged mechanical ventilation decreased the chances of survival without these morbidities. Maternal smoking and higher gestational duration were associated with lower risk of severe ROP, whereas PDA and poor growth increased this risk. Conclusion: Half of the infants surviving extremely preterm birth suffered from severe neonatal morbidities. Studies on how to reduce these morbidities and on the long-term health of survivors are warranted.
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| 3. |
- Beland, Marie-Claude, et al.
(author)
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Optical measurement and perception of gloss quality of printed matte-coated paper
- 1998
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In: Proceedings of the International Printing and Graphic Arts Conference. - : CPPA, Montreal, Canada. ; , s. 187-191
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Conference paper (peer-reviewed)abstract
- A set of 32 commercially produced and printed matte-coated papers were rated for gloss quality by a panel of 13 expert judges and light scattering distributions, gloss, and gloss variation measured. Fitting the light scattering distributions to Von Mises distributions, we obtain a factor, kappa, related to the width of the distribution and sensitive to small changes in surface roughness, which relates very well with the subjective rating. Gloss variation in certain surface spatial wavelength bands also correlates well with the gloss quality rating. The topography of the samples was also measured using confocal microscopy and the relationship between light scattering and paper topography is discussed.
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| 4. |
- Cederholm, Tommy, et al.
(author)
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Forskaren, samhället och jäv
- 2008
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In: Läkartidningen. - 0023-7205. ; 105:16, s. 7-1206
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Journal article (other academic/artistic)
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