| 1. |
- Spurdle, Amanda B., et al.
(författare)
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Common Genetic Variation at BARD1 Is Not Associated with Breast Cancer Risk in BRCA1 or BRCA2 Mutation Carriers
- 2011
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Ingår i: Cancer Epidemiology Biomarkers & Prevention. - 1538-7755 .- 1055-9965. ; 20:5, s. 1032-1038
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Tidskriftsartikel (refereegranskat)abstract
- Background: Inherited BRCA1 and BRCA2 (BRCA1/2) mutations confer elevated breast cancer risk. Knowledge of factors that can improve breast cancer risk assessment in BRCA1/2 mutation carriers may improve personalized cancer prevention strategies. Methods: A cohort of 5,546 BRCA1 and 2,865 BRCA2 mutation carriers was used to evaluate risk of breast cancer associated with BARD1 Cys557Ser. In a second nonindependent cohort of 1,537 of BRCA1 and 839 BRCA2 mutation carriers, BARD1 haplotypes were also evaluated. Results: The BARD1 Cys557Ser variant was not significantly associated with risk of breast cancer from single SNP analysis, with a pooled effect estimate of 0.90 (95% CI: 0.71-1.15) in BRCA1 carriers and 0.87 (95% CI: 0.59-1.29) in BRCA2 carriers. Further analysis of haplotypes at BARD1 also revealed no evidence that additional common genetic variation not captured by Cys557Ser was associated with breast cancer risk. Conclusion: Evidence to date does not support a role for BARD1 variation, including the Cy557Ser variant, as a modifier of risk in BRCA1/2 mutation carriers. Impact: Interactors of BRCA1/2 have been implicated as modifiers of BRCA1/2-associated cancer risk. Our finding that BARD1 does not contribute to this risk modification may focus research on other genes that do modify BRCA1/2-associated cancer risk. Cancer Epidemiol Biomarkers Prev; 20(5); 1032-38. (C) 2011 AACR.
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| 2. |
- Almeida, Teresa, et al.
(författare)
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Woman-Centred Design
- 2018
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Ingår i: DRS 2018. - UK : Design Research Society. - 9781912294367
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Balaam, Madeline, et al.
(författare)
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Hacking Women’s Health
- 2017
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Ingår i: CHI EA '17 Proceedings of the 2017 CHI Conference Extended Abstracts on Human Factors in Computing Systems, Denver, Colorado, USA — May 06 - 11, 2017. - New York, NY, USA : ACM. - 9781450346566 ; , s. 476-483
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Konferensbidrag (refereegranskat)abstract
- The aim of this two-day workshop is to bring together a nascent community of researchers to share research, ideas, methods and tools that can encourage, inspire and strengthen those of us working on digital women's health. Our workshop aims to take a pro-active stance, offering participants the opportunity to critique, design and hack existing and new women's digital health experiences. Or, in other words, to get their hands dirty. Through our hack-led event we aim to face headon issues related to digital women's health, such as taboo, power and prejudice. This workshop will address current gaps in research and practice by enabling us to develop the confidence, networks and strategies that can facilitate researchers/designers/technologists to work within this space.
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| 4. |
- Balaam, Madeline, et al.
(författare)
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Intimate Touch
- 2020
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Ingår i: interactions. - : Association for Computing Machinery. - 1072-5520 .- 1558-3449. ; 27:6, s. 14-17
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Campo Woytuk, Nadia, et al.
(författare)
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From Menstrual Care to Environmental Care
- 2023
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Ingår i: interactions. - : Association for Computing Machinery (ACM). - 1072-5520 .- 1558-3449. ; 30:4, s. 28-33
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 6. |
- Campo Woytuk, Nadia, et al.
(författare)
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Touching and Being in Touch with the Menstruating Body
- 2020
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Ingår i: Conference on Human Factors in Computing Systems - Proceedings. - New York, NY, USA : Association for Computing Machinery (ACM).
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Konferensbidrag (refereegranskat)abstract
- We describe a Research through Design project-Curious Cycles-A collection of objects and interactions which encourage people to be in close contact with their menstruating body. Throughout a full menstrual cycle, five participants used Curious Cycles to look at their bodies in unfamiliar ways and to touch their bodily fluids, specifically, menstrual blood, saliva, and cervical mucus. The act of touching and looking led to the construction of new knowledge about the self and to a nurturing appreciation for the changing body. Yet, participants encountered and reflected upon frictions within themselves, their home, and their social surroundings, which stem from societal stigma and preconceptions about menstruation and bodily fluids. We call for and show how interaction design can engage with technologies that mediate self-touch as a first step towards reconfiguring the way menstruating bodies are treated in society.
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| 7. |
- Ciolfi Felice, Marianela, et al.
(författare)
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Analyzing User Reviews of the First Digital Contraceptive : Mixed Methods Study
- 2023
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Ingår i: Journal of Medical Internet Research. - : JMIR Publications Inc.. - 1438-8871. ; 25, s. e47131-
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: People in Western countries are increasingly rejecting hormone-based birth control and expressing a preference for hormone-free methods. Digital contraceptives have emerged as nonhormonal medical devices that make use of self-tracked data and algorithms to find a user's fertile window. However, there is little knowledge about how people experience this seemingly new form of contraception, whose failure may result in unwanted pregnancies, high health risks, and life-changing consequences. As digital contraception becomes more widely adopted, examining its user experience is crucial to inform the design of technologies that not only are medically effective but also meet users' preferences and needs. OBJECTIVE: We examined the user experience offered by Natural Cycles-the first digital contraceptive-through an analysis of app reviews written by its users worldwide. METHODS: We conducted a mixed methods analysis of 3265 publicly available reviews written in English by users of Natural Cycles on the Google Play Store. We combined computational and human techniques, namely, topic modeling and reflexive thematic analysis. RESULTS: For some users of digital contraception, the hormone-free aspect of the experience can be more salient than its digital aspect. Cultivating self-knowledge through the use of the technology can, in turn, feel empowering. Users also pointed to an algorithmic component that allows for increased accuracy over time as long as user diligence is applied. The interactivity of the digital contraceptive supports mutual learning and is experienced as agential and rewarding. Finally, a digital contraceptive can facilitate sharing the burden of contraceptive practices or highlight single-sided responsibilities while creating points of friction in the required daily routines. CONCLUSIONS: Digital contraception is experienced by users as a tamed natural approach-a natural method contained and regulated by science and technology. This means that users can experience a method based on a digital product as "natural," which positions digital contraceptives as a suitable option for people looking for evidence-based nonhormonal contraceptive methods. We point to interactivity as core to the user experience and highlight that a digital contraceptive might allow for collaboration between partners around contraceptive practices and responsibilities. We note that the user diligence required for the digital contraceptive to provide accurate and frequent data is sometimes not enough. Future research could look at designing (and redesigning) digital contraceptives with primary users and intimate partners, enhancing the experience of tamed naturalness; exploring how trust fluctuates among involved actors and in interactions with the technology; and, ultimately, designing more inclusive approaches to digital contraception.
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| 8. |
- Ciolfi Felice, Marianela, et al.
(författare)
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Resisting the Medicalisation of Menopause : Reclaiming the Body through Design
- 2021
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Ingår i: CHI '21. - New York, USA : Association for Computing Machinery (ACM).
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Konferensbidrag (refereegranskat)abstract
- The menopause transition involves bodily-rooted, socially-shaped changes, often in a context of medicalisation that marginalises people based on their age and gender. With the goal of addressng this social justice matter with a participatory design approach, we started to cultivate partnerships with people going through menopause. This paper reports on interviews with 12 women and a design workshop with three. Our data analysis highlights their experiences from a holistic perspective that reclaims the primacy of the body and acknowledges the entanglement of the physical and the psychosocial. Participants’ design concepts show how design can come close the body to make space for menopause experiences, recognising and transforming them. We discuss how HCI can actively engage with the body to promote appreciation for it during menopause, and call for design that accompanies people in resisting the medicalisation of menopause as an enactment of social justice in everyday life.
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| 9. |
- Hamdi, Yosr, et al.
(författare)
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Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression : identification of a modifier of breast cancer risk at locus 11q22.3
- 2017
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Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 0167-6806 .- 1573-7217. ; 161:1, s. 117-134
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Cis-acting regulatory SNPs resulting in differential allelic expression (DAE) may, in part, explain the underlying phenotypic variation associated with many complex diseases. To investigate whether common variants associated with DAE were involved in breast cancer susceptibility among BRCA1 and BRCA2 mutation carriers, a list of 175 genes was developed based of their involvement in cancer-related pathways. Methods: Using data from a genome-wide map of SNPs associated with allelic expression, we assessed the association of ~320 SNPs located in the vicinity of these genes with breast and ovarian cancer risks in 15,252 BRCA1 and 8211 BRCA2 mutation carriers ascertained from 54 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2. Results: We identified a region on 11q22.3 that is significantly associated with breast cancer risk in BRCA1 mutation carriers (most significant SNP rs228595 p = 7 × 10−6). This association was absent in BRCA2 carriers (p = 0.57). The 11q22.3 region notably encompasses genes such as ACAT1, NPAT, and ATM. Expression quantitative trait loci associations were observed in both normal breast and tumors across this region, namely for ACAT1, ATM, and other genes. In silico analysis revealed some overlap between top risk-associated SNPs and relevant biological features in mammary cell data, which suggests potential functional significance. Conclusion: We identified 11q22.3 as a new modifier locus in BRCA1 carriers. Replication in larger studies using estrogen receptor (ER)-negative or triple-negative (i.e., ER-, progesterone receptor-, and HER2-negative) cases could therefore be helpful to confirm the association of this locus with breast cancer risk.
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| 10. |
- Helms, Karey, 1985-, et al.
(författare)
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Scaling Bodily Fluids For Utopian Fabulations
- 2021
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Ingår i: Proceedings of the 9th Bi-Annual Nordic Design Research Society Conference: Matters of Scale, 2021.
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Konferensbidrag (refereegranskat)abstract
- This paper explores human bodily fluids for more-than-human collaborative survival. We present four utopian fabulations in which urine, menstrual blood, and human milk are designed with beyond the scale of a singular human body. Each fabulation illustrates queer scales and uses of bodily fluids through extended or improper uses as pathways towards caring multi-species relations within a damaged environment. From these narratives, we reflect on imagining generous collaborations for an openness towards unknowable possibilities and crafting different measures through the tensions of coinciding scales.
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