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Sökning: WFRF:(Kanhed Satish)

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1.
  • Kanhed, Satish, et al. (författare)
  • Microporous Hydroxyapatite Ceramic Composites as Tissue Engineering Scaffolds : An Experimental and Computational Study
  • 2018
  • Ingår i: Advanced Engineering Materials. - : Wiley. - 1438-1656 .- 1527-2648. ; 20:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Bone‐tissue engineering mandates the development of multi‐functional bioactive porous hydroxyapatite (HAp) scaffolds. Herein, microwave sintered HAp/ZnO and HAp/Ag composite scaffolds with ≈5–19% porosity are developed using 0–30 vol% graphite as a porogen. The mechanical properties of the porous scaffold are analyzed in detail, revealing that even being more porous, the reinforcement of ZnO (9% porosity, hardness of 2.8 GPa, and toughness of 3.5 MPa.m1/2) has shown to have better hardness and fracture toughness when compared to Ag (5% porosity, hardness of 1.6 GPa, and toughness of 2.6 MPa.m1/2). The flexural strength obtained experimentally are complemented with a finite‐element technique that adopts microstructural features in visualizing the effect of porosity on stress distribution. The antibacterial efficacy and cytocompatibility of these composites are validated by increased metabolic activity and conspicuous cell‐matrix interactions. The anticipation of the results reveal that HAp/ZnO (9% porosity) and HAp/Ag (5% porosity) composites can be used as a potential multi‐functional bone implant scaffolds.
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2.
  • Kanhed, Satish, et al. (författare)
  • Porosity distribution affecting mechanical and biological behaviour of hydroxyapatite bioceramic composites
  • 2017
  • Ingår i: Ceramics International. - : Elsevier BV. - 0272-8842 .- 1873-3956. ; 43:13, s. 10442-10449
  • Tidskriftsartikel (refereegranskat)abstract
    • The present work aims to the study of developing porosity in hydroxyapatite (HAp) scaffold by using graphite porogen (with 0-30 vol%) followed by engineering the changes achieved by conventional- (CS) and microwave sintering (MS) techniques. The generated porosity was controlled between similar to 6-27% as the porogen concentration increases in HAp scaffold. Voronoi tessellation was utilized in order to evaluate the distribution of pores. The enhanced mechanical properties including fracture toughness (0.83 MPa m(1/2)), fracture strength (7.5 MPa), and hardness (183.7 VHN) were observed for microwave sintered HAp scaffold with 8% porosity. The fitting between porosity and fracture strength elicited that microwave sintered HAp with 8% porosity provides maximum crack-propagation resistance while restricting grain size (similar to 0.23 mu m) and eliciting high extent of sintering (similar to 1.34) because of their rapid heating rates. The cell viability (MTT assay) and cell culture confirm the cytocompatibility of porous HAp for application as bone implant that need accelerated replacement of bone tissues.
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