SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Karp Natasha A.) "

Search: WFRF:(Karp Natasha A.)

  • Result 1-4 of 4
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • 2019
  • Journal article (peer-reviewed)
  •  
2.
  • Briend, Emmanuel, et al. (author)
  • IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD
  • 2017
  • In: Respiratory Research. - : Springer Science and Business Media LLC. - 1465-9921 .- 1465-993X. ; 18:1
  • Journal article (peer-reviewed)abstract
    • Background: Increased interferon gamma (IFNγ) release occurs in Chronic Obstructive Pulmonary Disease (COPD) lungs. IFNγ supports optimal viral clearance, but if dysregulated could increase lung tissue destruction. Methods: The present study investigates which mediators most closely correlate with IFNγ in sputum in stable and exacerbating disease, and seeks to shed light on the spatial requirements for innate production of IFNγ, as reported in mouse lymph nodes, to observe whether such microenvironmental cellular organisation is relevant to IFNγ production in COPD lung. Results: We show tertiary follicle formation in severe disease alters the dominant mechanistic drivers of IFNγ production, because cells producing interleukin-18, a key regulator of IFNγ, are highly associated with such structures. Interleukin-1 family cytokines correlated with IFNγ in COPD sputum. We observed that the primary source of IL-18 in COPD lungs was myeloid cells within lymphoid aggregates and IL-18 was increased in severe disease. IL-18 released from infected epithelium or from activated myeloid cells, was more dominant in driving IFNγ when IL-18-producing and responder cells were in close proximity. Conclusions: Unlike tight regulation to control infection spread in lymphoid organs, this local interface between IL-18-expressing and responder cell is increasingly supported in lung as disease progresses, increasing its potential to increase tissue damage via IFNγ.
  •  
3.
  • Voelkl, Bernhard, et al. (author)
  • Reproducibility of animal research in light of biological variation
  • 2020
  • In: Nature Reviews Neuroscience. - : Nature Publishing Group. - 1471-003X .- 1471-0048. ; 21, s. 384-393
  • Journal article (peer-reviewed)abstract
    • In this Perspective, Hanno Wurbel and colleagues argue that a disregard for incorporating biological variation in study design is an important cause of poor reproducibility in animal research. They put the case for the use of systematic heterogenization of study samples and conditions in studies to improve reproducibility.Context-dependent biological variation presents a unique challenge to the reproducibility of results in experimental animal research, because organisms' responses to experimental treatments can vary with both genotype and environmental conditions. In March 2019, experts in animal biology, experimental design and statistics convened in Blonay, Switzerland, to discuss strategies addressing this challenge. In contrast to the current gold standard of rigorous standardization in experimental animal research, we recommend the use of systematic heterogenization of study samples and conditions by actively incorporating biological variation into study design through diversifying study samples and conditions. Here we provide the scientific rationale for this approach in the hope that researchers, regulators, funders and editors can embrace this paradigm shift. We also present a road map towards better practices in view of improving the reproducibility of animal research.
  •  
4.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-4 of 4
Type of publication
journal article (4)
Type of content
peer-reviewed (3)
other academic/artistic (1)
Author/Editor
Schielzeth, Holger (2)
Forsman, Anders, 196 ... (2)
Kelly, Daniel (1)
Bengtsson-Palme, Joh ... (1)
Nilsson, Henrik (1)
Kelly, Ryan (1)
show more...
Li, Ying (1)
Moore, Matthew D. (1)
Liu, Fang (1)
Zhang, Yao (1)
Jin, Yi (1)
Raza, Ali (1)
Rafiq, Muhammad (1)
Zhang, Kai (1)
Khatlani, T (1)
Kahan, Thomas (1)
Sörelius, Karl, 1981 ... (1)
Batra, Jyotsna (1)
Roobol, Monique J (1)
Backman, Lars (1)
Yan, Hong (1)
Schmidt, Axel (1)
Lorkowski, Stefan (1)
Thrift, Amanda G. (1)
Zhang, Wei (1)
Hammerschmidt, Sven (1)
Patil, Chandrashekha ... (1)
Wang, Jun (1)
Pollesello, Piero (1)
Conesa, Ana (1)
El-Esawi, Mohamed A. (1)
Zhang, Weijia (1)
Li, Jian (1)
Marinello, Francesco (1)
Frilander, Mikko J. (1)
Wei, Pan (1)
Badie, Christophe (1)
Zhao, Jing (1)
Li, You (1)
Bansal, Abhisheka (1)
Rahman, Proton (1)
Mori, Michiko (1)
Parchi, Piero (1)
Polz, Martin (1)
Ijzerman, Adriaan P. (1)
Subhash, Santhilal, ... (1)
Erjefält, Jonas S. (1)
Quinn, Terence J. (1)
Uversky, Vladimir N. (1)
Gemmill, Alison (1)
show less...
University
Lund University (2)
Linnaeus University (2)
University of Gothenburg (1)
Uppsala University (1)
Halmstad University (1)
Stockholm University (1)
show more...
Chalmers University of Technology (1)
Karolinska Institutet (1)
show less...
Language
English (4)
Research subject (UKÄ/SCB)
Natural sciences (3)
Medical and Health Sciences (2)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view