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- Centeno, D, et al.
(författare)
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Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-damage-sensing-dependent Cell Protection
- 2024
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Ingår i: bioRxiv : the preprint server for biology. - : Cold Spring Harbor Laboratory.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Loss of treatment-induced ovarian carcinoma (OC) growth suppression poses a major clinical challenge because it leads to disease recurrence. Therefore, new and well-tolerated approaches to maintain OC suppression after standard-of-care treatment are needed. We have profiled ascites as OC tumor microenvironments (TMs) to search for potential components that would exert growth suppression on OC cell cultures. Our investigations revealed that low levels of taurine, a non-proteogenic sulfonic amino acid, were present within OC ascites. Taurine supplementation, beyond levels found in ascites, induced growth suppression without causing cytotoxicity in multiple OC cell cultures, including patient-derived chemotherapy-resistant spheroid and organoid cultures. Suppression of proliferation by taurine was associated with the inhibition of glycolysis, mitochondrial function, and the activation of p21 and TIGAR, theTP53-dependent and independent tumor suppression regulatory pathways. Expression of p21 or TIGAR in various OC cells, in part, mimicked taurine-induced inhibition of OC cell proliferation. Our data support the potential therapeutic value of taurine supplementation in OC after chemotherapy.
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| 4. |
- Kochetkova, E, et al.
(författare)
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Extraction of Metabolites from Cancer Cells
- 2022
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Ingår i: Methods in molecular biology (Clifton, N.J.). - New York, NY : Springer US. - 1940-6029. ; 2445, s. 329-335
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Tidskriftsartikel (refereegranskat)
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| 6. |
- González-Galán, A., et al.
(författare)
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Spin period evolution of GX 1+4
- 2012
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 537
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We aim both to complement the existing data on the spin history of the peculiar accreting X-ray pulsar GX 1+4 with more past and current data from BeppoSAX, INTEGRAL, and Fermi and to interpret the evolution in the framework of accretion theory.Methods. We used source light curves obtained from BeppoSAX/WFC and INTEGRAL/ISGRI to derive pulse periods using an epoch-folding analysis. Fermi/GBM data were analysed by fitting a constant plus a Fourier expansion to background-subtracted rates, and maximizing the Y-2 statistic. We completed the sample with hard X-ray light curves from Swift/BAT. The data were checked for correlations between flux and changes of the pulsar spin on different timescales.Results. The spin-down of the pulsar continues with a constant change in frequency, i.e., an apparently accelerating change in the period. Over the past three decades, the pulse period has increased by about similar to 50%. Short-term fluctuations on top of this long-term trend do show anti-correlation with the source flux. Possible explanations of the observed long-term frequency and its dependence on flux are discussed.
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